Type II interferon signaling (IFNG) (Gallus gallus)

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1P[P]BORORPCytoplasm-P[P]NucleusOBO&BExtracellularSpacePAP&TTORORORBT[P] [P]B[P]PPlasmaMembraneIRF2PSMB9CIITAIFIT2IRF9RCJMB04_17i9RCJMB04_17i9(ISGF3)RCJMB04_17i9CXCL9JAK2STAT2 [P]IFNGIFNGR2HLA-BIRF1RCJMB04_17i9JAK1G1P3(ISGF3)RCJMB04_17i9JAK1RCJMB04_17i9IFNASOCS1RCJMB04_17i9IFNGR1OAS1GBP1STAT2CXCL10IFNGR1IRF9RCJMB04_17i9IFNB1JAK1SPI1JAK1STAT2EIF2AK2IFNGR1G1P2TAP1IFNGR2HIST2H4NOS2SOCS3JAK2ICAM1RCJMB04_17i9IFNGPTPN11RCJMB04_17i9RCJMB04_17i9RCJMB04_17i9CYBBIFNGPRKCDRCJMB04_17i9IRF9IFNGIL1BSTAT2IFNGR2RCJMB04_17i9IRF8IFNGR1PTPIRF8IRF9JAK2RCJMB04_17i9RCJMB04_17i9IFNGIFNGR2IRF9IRF4JAK2RCJMB04_17i9


Description

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP619(r28124) with a 60% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, Freeman TC; ''A logic-based diagram of signalling pathways central to macrophage activation.''; BMC Syst Biol, 2008 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
87832view11:45, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
71171view11:08, 11 October 2013Mkutmonfix unconnected line
68832view17:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
40968view22:54, 1 March 2011MaintBotRemoved redundant pathway information and comments
33893view17:57, 9 December 2009MaintBotAutomatic update of empty xrefs
33464view15:03, 30 November 2009MaintBotRemoved group label
31516view21:38, 13 August 2009MaintBotFixed text labels
30355view20:54, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(ISGF3)GeneProduct
CIITAGeneProduct427676 (Entrez Gene)
CXCL10GeneProduct
CXCL9GeneProduct
CYBBGeneProduct418581 (Entrez Gene)
EIF2AK2GeneProduct395147 (Entrez Gene)
G1P2GeneProduct
G1P3GeneProduct
GBP1GeneProduct
HIST2H4GeneProduct
HLA-BGeneProduct
ICAM1GeneProduct
IFIT2GeneProduct
IFNAGeneProduct396398 (Entrez Gene)
IFNB1GeneProduct
IFNGGeneProduct396054 (Entrez Gene)
IFNGR1GeneProduct421685 (Entrez Gene)
IFNGR2GeneProduct418502 (Entrez Gene)
IL1BGeneProduct395196 (Entrez Gene)
IRF1GeneProduct396384 (Entrez Gene)
IRF2GeneProduct396115 (Entrez Gene)
IRF4GeneProduct374179 (Entrez Gene)
IRF8GeneProduct396385 (Entrez Gene)
IRF9GeneProduct
JAK1GeneProduct395681 (Entrez Gene)
JAK2GeneProduct374199 (Entrez Gene)
NOS2GeneProduct395807 (Entrez Gene)
OAS1GeneProduct
PRKCDGeneProduct415905 (Entrez Gene)
PSMB9GeneProduct
PTPGeneProduct
PTPN11GeneProduct395815 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
SOCS1GeneProduct416630 (Entrez Gene)
SOCS3GeneProduct395299 (Entrez Gene)
SPI1GeneProduct395879 (Entrez Gene)
STAT2GeneProduct
STAT2 [P]GeneProduct
TAP1GeneProduct427727 (Entrez Gene)

Annotated Interactions

No annotated interactions
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