Wnt Signaling Pathway and Pluripotency (Gallus gallus)

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1+pTR: Transcriptional RegulationFrizzled LigandsProtein Kinase C+pRecruitment to UnknownUbiquitin Conjugating EnzymeCytoskeletonApoptosisDifferentiationTcf/Lef-126S Proteasome DegradationTRNucleusTRWnt ReceptorsPhosphorylated beta-cateninTRPromotes DifferentiationStabilized beta-cateninPP2APluripotency+pPromotes Pluripotencybeta-cateninbeta-cateninTcf/Lef-1Ubiquitin Taggedbeta-cateninBIOTcf/Lef-1TRIQ142EP300POU5F1CD44NLKPPP2R2BCREBBPWNT10AWNT2BJUNRCJMB04_16p24RCJMB04_5f2WNT11LEF1MAPK9TCF7L1PPP2R5EWNT7BWNT2PPP2R1ACCND2PPP2R3AGSK3BFZD6PPP2R5CRCJMB04_11b2FZD10_CHICKAXIN2DVL2AXIN1WNT16FOSL1NP_989878.1RCJMB04_5a10PLAUDVL3FBXW2PRKCCWNT1FRAT1MMP7NKD2FZD5FZD1WNT7AFZD4WNT11PRKCZLDLRPRKCBPPP2R4RACGAP1RCJMB04_21j12PPP2CBNANOGFZD8SOX2ZBTB33FZD7RCJMB04_12k21WNT4PRKCDFOXD3_CHICKPRKCQCTBP1MAPK10WNT5BRCJMB04_2d20WNT3APPP2R3BPPP2R1BAPCNP_001006325.1CTBP2CSNK1ELRP6WNT5AGrouchoRHOANKD1CTNNB1MYCWNT10BPAFAH1B1FZD3TP53PPP2CAQ9IB43_CHICKPRKCHPRKCEWNT3PPM1JPPP2R2CWNT9BPPARDFZD2WNT6CCND3CCND1FZD9MAP3K7


Description

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining

Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP399(r29616) with a 82% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. ''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html
  2. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC
  3. Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.''; Mol Cell Biol, 2006 PubMed Europe PMC
  4. Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
74237view09:31, 9 April 2014EgonwRemoved a data source where no ID was given.
67759view11:59, 26 June 2013DdiglesOntology Term : 'canonical Wnt signaling pathway' added !
62329view16:29, 27 April 2013EgonwWidened some node to make the full label readable.
58769view22:15, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
47793view16:32, 6 April 2012Khanspersupdated xrefs
40929view22:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
33860view17:45, 9 December 2009MaintBotAutomatic update of empty xrefs
33460view15:02, 30 November 2009MaintBotRemoved group label
31511view21:36, 13 August 2009MaintBotFixed text labels
30348view20:52, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCGeneProduct415607 (Entrez Gene)
AXIN1GeneProduct395786 (Entrez Gene)
AXIN2GeneProduct395152 (Entrez Gene)
CCND1GeneProduct396341 (Entrez Gene)
CCND2GeneProduct374047 (Entrez Gene)
CCND3GeneProduct419928 (Entrez Gene)
CD44GeneProduct395666 (Entrez Gene)
CREBBPGeneProduct416667 (Entrez Gene)
CSNK1EGeneProduct378891 (Entrez Gene)
CTBP1GeneProduct422904 (Entrez Gene)
CTBP2GeneProduct423958 (Entrez Gene)
CTNNB1GeneProduct395964 (Entrez Gene)
DVL2GeneProduct
DVL3GeneProduct424949 (Entrez Gene)
EP300GeneProduct418000 (Entrez Gene)
FBXW2GeneProduct417088 (Entrez Gene)
FOSL1GeneProduct
FOXD3_CHICKGeneProductENSGALG00000012644 (Ensembl)
FRAT1GeneProduct
FZD10_CHICKGeneProductENSGALG00000002652 (Ensembl)
FZD1GeneProduct374062 (Entrez Gene)
FZD2GeneProduct374061 (Entrez Gene)
FZD3GeneProduct395572 (Entrez Gene)
FZD4GeneProduct373887 (Entrez Gene)
FZD5GeneProduct374112 (Entrez Gene)
FZD6GeneProduct378788 (Entrez Gene)
FZD7GeneProduct374060 (Entrez Gene)
FZD8GeneProduct374059 (Entrez Gene)
FZD9GeneProduct373886 (Entrez Gene)
GSK3BGeneProduct418335 (Entrez Gene)
GrouchoGeneProduct
JUNGeneProduct424673 (Entrez Gene)
LDLRGeneProduct395103 (Entrez Gene)
LEF1GeneProduct395865 (Entrez Gene)
LRP6GeneProduct419097 (Entrez Gene)
MAP3K7GeneProduct421808 (Entrez Gene)
MAPK10GeneProduct422592 (Entrez Gene)
MAPK9GeneProduct395983 (Entrez Gene)
MMP7GeneProduct418983 (Entrez Gene)
MYCGeneProduct420332 (Entrez Gene)
NANOGGeneProduct100272166 (Entrez Gene)
NKD1GeneProduct415729 (Entrez Gene)
NKD2GeneProduct
NLKGeneProduct417669 (Entrez Gene)
NP_001006325.1GeneProductENSGALG00000003247 (Ensembl)
NP_989878.1GeneProductENSGALG00000006480 (Ensembl)
PAFAH1B1GeneProduct374224 (Entrez Gene)
PLAUGeneProduct396424 (Entrez Gene)
POU5F1GeneProduct
PPARDGeneProduct395479 (Entrez Gene)
PPM1JGeneProductENSGALG00000001605 (Ensembl)
PPP2CAGeneProduct416318 (Entrez Gene)
PPP2CBGeneProduct396021 (Entrez Gene)
PPP2R1AGeneProduct
PPP2R1BGeneProduct777130 (Entrez Gene)
PPP2R2BGeneProduct416350 (Entrez Gene)
PPP2R2CGeneProduct422858 (Entrez Gene)
PPP2R3AGeneProduct424733 (Entrez Gene)
PPP2R3BGeneProduct418670 (Entrez Gene)
PPP2R4GeneProduct426329 (Entrez Gene)
PPP2R5CGeneProduct423460 (Entrez Gene)
PPP2R5EGeneProduct423512 (Entrez Gene)
PRKCBGeneProduct416567 (Entrez Gene)
PRKCCGeneProduct
PRKCDGeneProduct415905 (Entrez Gene)
PRKCEGeneProduct421409 (Entrez Gene)
PRKCHGeneProduct423518 (Entrez Gene)
PRKCQGeneProduct
PRKCZGeneProduct419399 (Entrez Gene)
Q9IB43_CHICKGeneProductENSGALG00000008883 (Ensembl)
RACGAP1GeneProduct426884 (Entrez Gene)
RCJMB04_11b2GeneProduct423114 (Entrez Gene)
RCJMB04_12k21GeneProduct423302 (Entrez Gene)
RCJMB04_16p24GeneProduct424991 (Entrez Gene)
RCJMB04_21j12GeneProduct428852 (Entrez Gene)
RCJMB04_2d20GeneProduct419416 (Entrez Gene)
RCJMB04_5a10GeneProduct417430 (Entrez Gene)
RCJMB04_5f2GeneProduct419523 (Entrez Gene)
RHOAGeneProduct395442 (Entrez Gene)
SOX2GeneProduct396105 (Entrez Gene)
TCF7L1GeneProduct395230 (Entrez Gene)
TP53GeneProduct396200 (Entrez Gene)
WNT1GeneProduct
WNT10AGeneProduct429040 (Entrez Gene)
WNT10BGeneProduct
WNT11GeneProduct395562 (Entrez Gene) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
WNT16GeneProduct427856 (Entrez Gene)
WNT2GeneProduct417769 (Entrez Gene)
WNT2BGeneProduct374243 (Entrez Gene)
WNT3GeneProduct395396 (Entrez Gene)
WNT3AGeneProduct
WNT4GeneProduct395561 (Entrez Gene)
WNT5AGeneProduct395703 (Entrez Gene)
WNT5BGeneProduct418154 (Entrez Gene)
WNT6GeneProduct395235 (Entrez Gene)
WNT7AGeneProduct374168 (Entrez Gene)
WNT7BGeneProduct427937 (Entrez Gene)
WNT9BGeneProduct771092 (Entrez Gene)
ZBTB33GeneProduct422367 (Entrez Gene)

Annotated Interactions

No annotated interactions
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