TCA Cycle (Gallus gallus)

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GlycolysisCytosolFatty Acid SynthesisElectron Transport ChainGluconeogenesisMitochondrionDegradation of Fatty AcidsContaining an Odd Number of CarbonsDegradation of Fatty AcidsContaining an Even Number of CarbonsSDHARCJMB04_39i8PyruvatePPM2CAcetyl-CoASuccinateRCJMB04_9n20OxaloacetateMDH2SDHCMalateRCJMB04_4o20Succinyl-CoAMDH1IDH2IDH3GPDHBPDK4DLDPDK2FumaratePDHA1alpha-KetoglutaratePDHA2MalateIDH3AACO2DLATCitrateFHRCJMB04_17g4PDP2SUCLG1IsocitrateSDHDSUCLG2RCJMB04_19j12CSDLDPDK3SUCLA2PCOxaloacetateSDHB


The citric acid cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both Albert Szent-Gyorgyi and Hans Krebs. [From Wikipedia]


This pathway was inferred from Homo sapiens pathway WP78(r28870) with a 75% conversion rate.

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109456view10:32, 18 March 2020L DupuisConverted interaction lines representing membrane to graphical lines
106114view12:02, 16 August 2019MaintBotHMDB identifier normalization
87717view09:15, 25 July 2016MirellaKalafatiOntology Term : 'citric acid cycle pathway' added !
87716view09:15, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
68816view17:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
40951view22:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
33878view17:52, 9 December 2009MaintBotAutomatic update of empty xrefs
33453view15:00, 30 November 2009MaintBotRemoved group label
31505view21:34, 13 August 2009MaintBotFixed text labels
30339view20:48, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ACO2GeneProduct374009 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
CSGeneProduct100310659 (Entrez Gene)
CitrateMetaboliteHMDB0000094 (HMDB)
DLATGeneProduct419796 (Entrez Gene)
DLDGeneProduct417699 (Entrez Gene)
FHGeneProduct420969 (Entrez Gene)
FumarateMetaboliteHMDB0000134 (HMDB)
IDH3AGeneProduct415362 (Entrez Gene)
IsocitrateMetaboliteHMDB0000193 (HMDB)
MDH1GeneProduct421281 (Entrez Gene)
MDH2GeneProduct417517 (Entrez Gene)
MalateMetaboliteHMDB0000156 (HMDB)
OxaloacetateMetaboliteHMDB0000223 (HMDB)
PDHA1GeneProduct418610 (Entrez Gene)
PDHBGeneProduct416066 (Entrez Gene)
PDK3GeneProduct418595 (Entrez Gene)
PDK4GeneProduct420570 (Entrez Gene)
PDP2GeneProduct427550 (Entrez Gene)
PPM2CGeneProduct428372 (Entrez Gene)
PyruvateMetaboliteHMDB0000243 (HMDB)
RCJMB04_17g4GeneProduct423154 (Entrez Gene)
RCJMB04_19j12GeneProduct426429 (Entrez Gene)
RCJMB04_39i8GeneProduct423357 (Entrez Gene)
RCJMB04_4o20GeneProduct425972 (Entrez Gene)
RCJMB04_9n20GeneProduct426573 (Entrez Gene)
SDHAGeneProduct395758 (Entrez Gene)
SDHBGeneProduct770063 (Entrez Gene)
SDHDGeneProduct419793 (Entrez Gene)
SUCLA2GeneProduct418857 (Entrez Gene)
SUCLG1GeneProduct422932 (Entrez Gene)
SUCLG2GeneProduct416087 (Entrez Gene)
SuccinateMetaboliteHMDB0000254 (HMDB)
Succinyl-CoAMetaboliteHMDB0001022 (HMDB)

Annotated Interactions

No annotated interactions
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