MAPK Signaling Pathway (Gallus gallus)

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Scaffold1-91011LegendCalcium channelsCalcium channelsHeteromeric G-proteinActivating mutationProliferation, differentiationJNK & p38 MAP kinase pathwayERK5 pathwayClassical MAP kinase PathwayMKPProliferation, differentiation,inflammationSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressProliferation, inflammation, anti-apoptosisp38Proliferation, differentiationSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDNA damagePTPJNKTRAF6MEF2CPSRFRPS6KA3PMAP2K3PELK4PRAP1APCRKIL1APDGFBAKT3ECSITMAP3K13RASGRP4MAP3K7PMAPK9PGRB2MKNK1PDUSP1STMN1PELK1PPPEGFRPPP3CBPPP3CCMAP4K1NFATC1PARRB2MAPTPRASGRP1RAP1BPCD14IKBKGBDNFDAXXMAPK10PTNFMOSSTK4MAPK14PIKBKBPPARRB1LRRK2CASP3FLNAPRKACAMAPKAPK2PTNFRSF1AMAP3K14HSPB1PMAP3K20GNA12TGFB1MAP3K1PMAP3K2PMAXPDUSP10RASGRF2MAP4K4PDGFRBTAB1MAP3K4GADD45AWnt signaling pathwayMAP2K5CDC25BPIL1R1RAC2PRKCDPPP5CMAP2K1PPcRac1APTPN7IL1R2TAB2ChALK5MAPK1PPPTPRRPTPN5PLA2G4DPBRAFNTRK1ATF2PMAP2K4PLPSFOSPRKCGMYCSOS2TGFB2ELK1PMAPK7PDUSP4CACNG3ApoptosisHSPA8MAPK12PMAPK8IP1IP3PPM1ACa2+il-1betaELK4PTRAF2MAPK13PTAOK1MAP2K6PDUSP8AKT2MAPKAPK5PRASA2DUSP7PPP3R2FGFR1TGFB3PPP3CAEGFDDIT3PMAP3K6MAP3K8NGFCRKLTAOK2cAMPMAPK3PPMAPK8PNR4A1PCell cyclePRKCAATF4PNTF4PDGF-AATF4PNTRK2TNFSF6PDGFRBPPM1BFGFR2CDC42FGFR3LAMTOR3FGFR4JUNPPSOS1JUNDPRRASHRASPPRPS6KA5PMAP3K12TP53PRRAS2PNFKB1GNG12PLA2G4CPNF1RASGRP2AKT1p53 signaling pathwayRASGRP3RASGRP4RASA1RASGRF1HSPA6Ca2+NTF3RAPGEF2Phosphatidylinositolsignaling systemPRKACBHSPA1APRKACGSTK3DUSP3MAP4K3CHUKPTGFBR2NFKB2MAP4K2RELAMAP2K7PRELBPPP3R1DUSP9NLKPDUSP2DAGDUSP16FASMKNK2PPLA2G4APNFATC3PMAP3K5PMAP3K11PTAOK3DUSP6MAP2K2PPPPP5D1MAPK11PRPS6KA4PMAPKAPK3PcRac1BMAPK8IP2MAPK8IP3FLNBFLNCHSPA1BHSPA1LHSPA2MRASPNRASPKRASPRAF1PPLA2G4FPLA2G4BPPPLA2G4EPCACNG2CACNG5CACNG4CACNA2D3CACNG8CACNG7CACNG6CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1SCACNA2D1CACNB1CACNB2CACNB3CACNB4CACNG1CACNA1ICACNA1HCACNA1GCACNA2D2CACNA2D4FGF4FGF1FGF2FGF3FGF4FGF5FGF6Fgf7FGF8FGF9FGF10FGF11FGF12FGF13FGF14FGF20FGF21FGF22FGF23FGF-18FGF17Fgf16FGF19Fibroblast growth factorsFibroblast growthfactorsPAK2PAK1


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP382 (r95114) with a 82.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC
  2. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC
  3. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC
  4. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC
  5. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC
  6. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC
  7. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC
  8. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC
  9. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC
  10. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC
  11. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106113view12:01, 16 August 2019MaintBotHMDB identifier normalization
105689view21:00, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96344view09:30, 9 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95781view14:34, 19 January 2018MkutmonHomology conversion update
95119view15:03, 16 November 2017Mkutmonmissing homology converter comment source
95111view14:44, 16 November 2017DeSlFixed nested groups.
82861view14:48, 10 November 2015Mkutmoncorrected outdated identifiers
74228view15:24, 8 April 2014EgonwRemoved a data source where no ID was given.
68869view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67446view11:03, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
47784view16:17, 6 April 2012Khanspersupdated xref
41008view22:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
35665view22:30, 12 February 2010KhanspersDescription and lit refs
33929view18:10, 9 December 2009MaintBotAutomatic update of empty xrefs
33452view15:00, 30 November 2009MaintBotRemoved group label
31504view21:34, 13 August 2009MaintBotFixed text labels
30338view20:48, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSGALG00000011620 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:207
AKT2GeneProductENSGALG00000037736 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:208
AKT3GeneProductENSGALG00000034081 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10000
ARRB1GeneProductENSGALG00000033601 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:408
ARRB2GeneProductNo homologues found for original id L:409
ATF2GeneProductENSGALG00000009287 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1386
ATF4GeneProductENSGALG00000012135 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:468
ApoptosisPathwayWP254 (WikiPathways)
BDNFGeneProductENSGALG00000012163 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:627
BRAFGeneProductENSGALG00000012865 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:673
CACNA1AGeneProductENSGALG00000037131 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000141837
CACNA1BGeneProductENSGALG00000008456 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000148408
CACNA1CGeneProductENSGALG00000013022 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000151067
CACNA1DGeneProductENSGALG00000005332 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000157388
CACNA1EGeneProductENSGALG00000003833 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000198216
CACNA1FGeneProductENSGALG00000029356 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000102001
CACNA1GGeneProductENSGALG00000007623 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000006283
CACNA1HGeneProductENSGALG00000005215 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000196557
CACNA1IGeneProductENSGALG00000035051 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000100346
CACNA1SGeneProductENSGALG00000037744 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000081248
CACNA2D1GeneProductENSGALG00000008486 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000153956
CACNA2D2GeneProductENSGALG00000038242 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000007402
CACNA2D3GeneProductENSGALG00000005400 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000157445
CACNA2D4GeneProductENSGALG00000013007 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000151062
CACNB1GeneProductENSGALG00000025788 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000067191
CACNB2GeneProductENSGALG00000008591 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000165995
CACNB3GeneProductNo homologues found for original id En:ENSG00000167535
CACNB4GeneProductENSGALG00000035466 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000182389
CACNG1GeneProductENSGALG00000027771 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000108878
CACNG2GeneProductENSGALG00000031977 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000166862
CACNG3GeneProductENSGALG00000038087 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = H:CACNG3
CACNG4GeneProductENSGALG00000026091 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000075461
CACNG5GeneProductENSGALG00000003911 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000075429
CACNG6GeneProductNo homologues found for original id En:ENSG00000130433
CACNG7GeneProductENSGALG00000042886 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000105605
CACNG8GeneProductNo homologues found for original id En:ENSG00000142408
CASP3GeneProductENSGALG00000010638 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:836
CD14GeneProductENSGALG00000039140 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:929
CDC25BGeneProductNo homologues found for original id L:994
CDC42GeneProductENSGALG00000004796 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:998
CHUKGeneProductENSGALG00000003289 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000213341
CRKGeneProductENSGALG00000031595 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1398
CRKLGeneProductENSGALG00000006390 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1399
Ca2+MetaboliteHMDB0000464 (HMDB)
Cell cyclePathwayWP179 (WikiPathways)
ChALK5GeneProductENSGALG00000033179 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7046
DAGMetaboliteCHEBI:18035 (ChEBI)
DAXXGeneProductNo homologues found for original id L:1616
DDIT3GeneProductNo homologues found for original id L:1649
DUSP10GeneProductENSGALG00000009450 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:11221
DUSP16GeneProductENSGALG00000034033 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000111266
DUSP1GeneProductENSGALG00000040360 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1843
DUSP2GeneProductNo homologues found for original id En:ENSG00000158050
DUSP3GeneProductENSGALG00000035369 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000108861
DUSP4GeneProductENSGALG00000011419 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1846
DUSP6GeneProductENSGALG00000011207 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1848
DUSP7GeneProductENSGALG00000041650 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1849
DUSP8GeneProductENSGALG00000006647 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000184545
DUSP9GeneProductNo homologues found for original id En:ENSG00000130829
ECSITGeneProductENSGALG00000043823 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:51295
EGFGeneProductENSGALG00000012155 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1950
EGFRGeneProductENSGALG00000038089 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1956
ELK1GeneProductNo homologues found for original id L:2002
ELK4GeneProductENSGALG00000035274 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000158711
FASGeneProductENSGALG00000006351 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:355
FGF-18GeneProductENSGALG00000002203 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000156427
FGF10GeneProductENSGALG00000014872 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000070193
FGF11GeneProductNo homologues found for original id En:ENSG00000161958
FGF12GeneProductENSGALG00000036971 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000114279
FGF13GeneProductENSGALG00000006508 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000129682
FGF14GeneProductENSGALG00000016866 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000102466
FGF17GeneProductNo homologues found for original id En:ENSG00000158815
FGF19GeneProductENSGALG00000028376 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000162344
FGF1GeneProductENSGALG00000031255 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000113578
FGF20GeneProductENSGALG00000013663 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000078579
FGF21GeneProductNo homologues found for original id En:ENSG00000105550
FGF22GeneProductENSGALG00000041822 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000070388
FGF23GeneProductENSGALG00000027791 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000118972
FGF2GeneProductENSGALG00000011835 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000138685
FGF3GeneProductENSGALG00000026853 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000186895
FGF4GeneProductENSGALG00000007562 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000075388
FGF5GeneProductENSGALG00000045521 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000138675
FGF6GeneProductENSGALG00000017287 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000111241
FGF8GeneProductENSGALG00000007706 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000107831
FGF9GeneProductENSGALG00000025748 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000102678
FGFR1GeneProductENSGALG00000039786 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2260
FGFR2GeneProductENSGALG00000009495 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000066468
FGFR3GeneProductENSGALG00000015708 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000068078
FGFR4GeneProductENSGALG00000028543 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000160867
FLNAGeneProductNo homologues found for original id L:2316
FLNBGeneProductENSGALG00000005678 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000136068
FLNCGeneProductNo homologues found for original id En:ENSG00000128591
FOSGeneProductENSGALG00000028037 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2353
Fgf16GeneProductENSGALG00000007806 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000196468
Fgf7GeneProductENSGALG00000028158 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000140285
GADD45AGeneProductENSGALG00000025977 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1647
GNA12GeneProductENSGALG00000004368 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2768
GNG12GeneProductENSGALG00000026591 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000172380
GRB2GeneProductENSGALG00000008016 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:2885
HRASGeneProductENSGALG00000040551 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000174775
HSPA1AGeneProductNo homologues found for original id L:3303
HSPA1BGeneProductNo homologues found for original id En:ENSG00000204388
HSPA1LGeneProductNo homologues found for original id En:ENSG00000204390
HSPA2GeneProductENSGALG00000011715 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000126803
HSPA6GeneProductNo homologues found for original id En:ENSG00000173110
HSPA8GeneProductENSGALG00000006512 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3312
HSPB1GeneProductENSGALG00000001926 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3315
IKBKBGeneProductENSGALG00000031832 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3551
IKBKGGeneProductNo homologues found for original id L:8517
IL1AGeneProductNo homologues found for original id L:3552
IL1R1GeneProductENSGALG00000030526 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3554
IL1R2GeneProductENSGALG00000046326 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7850
IP3MetaboliteCHEBI:16595 (ChEBI)
JUNDGeneProductENSGALG00000043641 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3727
JUNGeneProductENSGALG00000010870 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3725
KRASGeneProductENSGALG00000030943 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3845
LAMTOR3GeneProductENSGALG00000000055 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8649
LPSMetaboliteCHEBI:16412 (ChEBI)
LRRK2GeneProductENSGALG00000007161 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000188906
MAP2K1GeneProductENSGALG00000007687 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5604
MAP2K2GeneProductENSGALG00000001267 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5605
MAP2K3GeneProductENSGALG00000041285 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5606
MAP2K4GeneProductENSGALG00000032178 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6416
MAP2K5GeneProductENSGALG00000007930 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5607
MAP2K6GeneProductENSGALG00000004370 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5608
MAP2K7GeneProductNo homologues found for original id L:5609
MAP3K11GeneProductNo homologues found for original id L:4296
MAP3K12GeneProductENSGALG00000031572 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7786
MAP3K13GeneProductENSGALG00000006655 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9175
MAP3K14GeneProductENSGALG00000000685 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000006062
MAP3K1GeneProductENSGALG00000014718 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4214
MAP3K20GeneProductENSGALG00000035237 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:51776
MAP3K2GeneProductENSGALG00000011502 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10746
MAP3K4GeneProductENSGALG00000020003 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4216
MAP3K5GeneProductENSGALG00000013892 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4217
MAP3K6GeneProductENSGALG00000030706 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9064
MAP3K7GeneProductENSGALG00000015596 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6885
MAP3K8GeneProductENSGALG00000007356 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1326
MAP4K1GeneProductNo homologues found for original id L:11184
MAP4K2GeneProductNo homologues found for original id En:ENSG00000168067
MAP4K3GeneProductENSGALG00000039720 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8491
MAP4K4GeneProductENSGALG00000016781 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9448
MAPK10GeneProductENSGALG00000011109 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5602
MAPK11GeneProductENSGALG00000040023 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000185386
MAPK12GeneProductENSGALG00000019384 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6300
MAPK13GeneProductENSGALG00000030966 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5603
MAPK14GeneProductENSGALG00000042833 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:1432
MAPK1GeneProductENSGALG00000001501 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5594
MAPK3GeneProductNo homologues found for original id L:5595
MAPK7GeneProductNo homologues found for original id L:5598
MAPK8GeneProductENSGALG00000006109 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5599
MAPK8IP1GeneProductENSGALG00000033060 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000121653
MAPK8IP2GeneProductENSGALG00000035559 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000008735
MAPK8IP3GeneProductENSGALG00000029514 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000138834
MAPK9GeneProductENSGALG00000039099 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5601
MAPKAPK2GeneProductENSGALG00000000883 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9261
MAPKAPK3GeneProductENSGALG00000002283 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000114738
MAPKAPK5GeneProductENSGALG00000004743 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8550
MAPTGeneProductENSGALG00000038894 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4137
MAXGeneProductENSGALG00000032249 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4149
MEF2CGeneProductENSGALG00000014645 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4208
MKNK1GeneProductENSGALG00000010440 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:8569
MKNK2GeneProductENSGALG00000003845 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000099875
MOSGeneProductENSGALG00000042082 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4342
MRASGeneProductENSGALG00000011592 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:22808
MYCGeneProductENSGALG00000033631 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4609
NF1GeneProductENSGALG00000005660 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000196712
NFATC1GeneProductENSGALG00000042534 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4772
NFATC3GeneProductENSGALG00000003396 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000072736
NFKB1GeneProductENSGALG00000012304 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4790
NFKB2GeneProductENSGALG00000005653 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000077150
NGFGeneProductENSGALG00000002556 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000134259
NLKGeneProductENSGALG00000005699 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:51701
NR4A1GeneProductENSGALG00000043727 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3164
NRASGeneProductENSGALG00000026692 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4893
NTF3GeneProductENSGALG00000027299 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000185652
NTF4GeneProductNo homologues found for original id En:ENSG00000225950
NTRK1GeneProductENSGALG00000019019 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:4914
NTRK2GeneProductENSGALG00000012594 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000148053
PAK1GeneProductENSGALG00000000681 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5058
PAK2GeneProductENSGALG00000006426 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5062
PDGF-AGeneProductENSGALG00000003642 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000197461
PDGFBGeneProductENSGALG00000012178 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5155
PDGFRBGeneProductENSGALG00000030613 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000113721
PLA2G4AGeneProductENSGALG00000005065 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000116711
PLA2G4BGeneProductENSGALG00000045155 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000243708
PLA2G4CGeneProductNo homologues found for original id En:ENSG00000105499
PLA2G4DGeneProductENSGALG00000045155 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000159337
PLA2G4EGeneProductENSGALG00000026584 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000188089
PLA2G4FGeneProductENSGALG00000043591 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000168907
PPM1AGeneProductENSGALG00000011917 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5494
PPM1BGeneProductENSGALG00000030691 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5495
PPP3CAGeneProductENSGALG00000039498 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5530
PPP3CBGeneProductENSGALG00000005243 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5532
PPP3CCGeneProductENSGALG00000041413 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5533
PPP3R1GeneProductENSGALG00000023648 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5534
PPP3R2GeneProductNo homologues found for original id L:5535
PPP5CGeneProductNo homologues found for original id L:5536
PPP5D1GeneProductNo homologues found for original id En:ENSG00000230510
PRKACAGeneProductNo homologues found for original id L:5566
PRKACBGeneProductENSGALG00000028530 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000142875
PRKACGGeneProductNo homologues found for original id En:ENSG00000165059
PRKCAGeneProductENSGALG00000025950 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000154229
PRKCDGeneProductENSGALG00000002016 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5580
PRKCGGeneProductNo homologues found for original id L:5582
PTPN5GeneProductENSGALG00000006368 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:84867
PTPN7GeneProductENSGALG00000036093 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5778
PTPRRGeneProductENSGALG00000010148 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5801
Phosphatidylinositol signaling systemPathway
RAC2GeneProductENSGALG00000012456 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5880
RAF1GeneProductENSGALG00000004998 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5894
RAP1AGeneProductENSGALG00000001476 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5906
RAP1BGeneProductENSGALG00000009927 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5908
RAPGEF2GeneProductENSGALG00000020249 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000109756
RASA1GeneProductENSGALG00000031015 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5921
RASA2GeneProductENSGALG00000002850 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5922
RASGRF1GeneProductENSGALG00000008262 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000058335
RASGRF2GeneProductENSGALG00000015598 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5924
RASGRP1GeneProductENSGALG00000009740 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10125
RASGRP2GeneProductNo homologues found for original id En:ENSG00000068831
RASGRP3GeneProductENSGALG00000010435 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000152689
RASGRP4GeneProductNo homologues found for original id En:ENSG00000171777
RELAGeneProductENSGALG00000039409 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000173039
RELBGeneProductNo homologues found for original id En:ENSG00000104856
RPS6KA3GeneProductENSGALG00000016406 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6197
RPS6KA4GeneProductNo homologues found for original id En:ENSG00000162302
RPS6KA5GeneProductENSGALG00000030580 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:9252
RRASGeneProductNo homologues found for original id En:ENSG00000126458
RRAS2GeneProductENSGALG00000005998 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000133818
SOS1GeneProductENSGALG00000039450 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000115904
SOS2GeneProductENSGALG00000012273 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6655
SRFGeneProductENSGALG00000032029 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6722
STK3GeneProductENSGALG00000032850 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:6788
STK4GeneProductENSGALG00000004098 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000101109
STMN1GeneProductENSGALG00000037927 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3925
TAB1GeneProductENSGALG00000012150 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:10454
TAB2GeneProductENSGALG00000012356 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:23118
TAOK1GeneProductENSGALG00000004082 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:57551
TAOK2GeneProductNo homologues found for original id L:9344
TAOK3GeneProductENSGALG00000007396 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000135090
TGFB1GeneProductENSGALG00000031325 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7040
TGFB2GeneProductENSGALG00000009612 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7042
TGFB3GeneProductENSGALG00000010346 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7043
TGFBR2GeneProductENSGALG00000011442 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7048
TNFGeneProductNo homologues found for original id L:7124
TNFRSF1AGeneProductENSGALG00000039461 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000067182
TNFSF6GeneProductENSGALG00000003076 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:356
TP53GeneProductNo homologues found for original id L:7157
TRAF2GeneProductENSGALG00000042838 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7186
TRAF6GeneProductENSGALG00000007932 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:7189
Wnt signaling pathwayPathwayWP428 (WikiPathways)
cAMPMetaboliteHMDB0000058 (HMDB)
cRac1AGeneProductENSGALG00000007130 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:5879
cRac1BGeneProductENSGALG00000040606 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = En:ENSG00000169750
il-1betaGeneProductENSGALG00000029940 (Ensembl) Homology Mapping from Homo sapiens to Gallus gallus: Original ID = L:3553
p53 signaling pathwayPathway

Annotated Interactions

No annotated interactions
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