DNA Replication (Gallus gallus)

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1, 2Orc complexMcm6RNA primer-DNA primer:origin duplex:PCNARFC Heteropentamer:RNA primer-DNA primerOrc4Mcm2RFC36Mcm2Mcm 4,6,7 trimer forms andassociates with the replication forkMcm3Orc complexOrc3Pre-replicative complexOrc2Ubiquitinated Orc1Mcm10RFC140Phosphorylation ofMcm 2-7 complexCdc6Cdt1Mcm3Cdc6Cdc6Cdt1Orc2Orc complexDNA polymerase alpha:primase: origin complexMcm7RFC37p58OriginOrc5RFC38RNA PrimerPre-replicative complexGeminin3. DNA replication initiationUbiquitinPhosphorylated Orc1RFC40Orc3Orc2Orc1Mcm5Orc4PrimasePhosphorylated Cdc6Orc5Mcm4Degraded by proteasome in cytosolOrc3Processive complexOrc3DNA polymerase alpha:primase: origin complexCdt1Orc24. Switching of origins to post-replicative stateMcm101. Assembly of the pre-replicative complexRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerp70Mcm4p180Orc complexMcm6RNA primer-DNA primerCdc6p49Degraded byproteasomein cytosolOrc5Cdt1Mcm75. Leading/lagging strand synthesisDNAPolymerase AOrc complexRNA primer-DNA primerUbiquitinated Cdc6Ubiquitin2. Activation of the pre-replicative complexCdt1Mcm5ADPRCJMB04_6d17ATPMCM10dATPORC6LCDT1MCM5ORC2LRFC5MCM6MCM2RPA3dUTPMCM4CDC6POLD2MCM7POLA1MCM3ATPATPPCNAPOLA2ORC4LRFC1GMNNUBA52POLECTPATPGTPORC5LCDC45LORC3LRFC2RPA1POLD4ADPPOLD1ORC1LUBCRPA4CDC7PRIM2UTPPOLD3RFC3RFC4dCTPdGTPPRIM1DBF4CDK2POLE2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 54% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
68859view17:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
68762view15:29, 7 July 2013EgonwRemoved data source where no ID was given.
67165view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40997view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35218view15:49, 11 February 2010Thomasadded literature
35210view15:44, 11 February 2010ThomasModified description
35204view15:41, 11 February 2010ThomasModified description
33918view18:06, 9 December 2009MaintBotAutomatic update of empty xrefs
33442view14:58, 30 November 2009MaintBotRemoved group label
31499view21:32, 13 August 2009MaintBotFixed text labels
30326view20:45, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CDC45LGeneProduct416776 (Entrez Gene)
CDC6GeneProduct
CDC7GeneProduct424507 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct426254 (Entrez Gene)
CTPMetabolite
DBF4GeneProduct420536 (Entrez Gene)
GMNNGeneProduct421004 (Entrez Gene)
GTPMetabolite
MCM10GeneProduct429525 (Entrez Gene)
MCM2GeneProduct416027 (Entrez Gene)
MCM3GeneProduct422043 (Entrez Gene)
MCM4GeneProduct426764 (Entrez Gene)
MCM5GeneProduct418058 (Entrez Gene)
MCM6GeneProduct424295 (Entrez Gene)
MCM7GeneProduct
ORC1LGeneProduct424640 (Entrez Gene)
ORC2LGeneProduct424077 (Entrez Gene)
ORC3LGeneProduct421822 (Entrez Gene)
ORC4LGeneProduct424307 (Entrez Gene)
ORC5LGeneProduct417714 (Entrez Gene)
ORC6LGeneProduct415749 (Entrez Gene)
PCNAGeneProduct373984 (Entrez Gene)
POLA1GeneProduct418593 (Entrez Gene)
POLA2GeneProduct
POLD1GeneProduct
POLD2GeneProduct
POLD3GeneProduct419053 (Entrez Gene)
POLD4GeneProduct
POLE2GeneProduct423567 (Entrez Gene)
POLEGeneProduct416997 (Entrez Gene)
PRIM1GeneProduct426646 (Entrez Gene)
PRIM2GeneProduct421878 (Entrez Gene)
RCJMB04_6d17GeneProduct419566 (Entrez Gene)
RFC1GeneProduct422788 (Entrez Gene)
RFC2GeneProduct396542 (Entrez Gene)
RFC3GeneProduct418907 (Entrez Gene)
RFC4GeneProduct424958 (Entrez Gene)
RFC5GeneProduct
RPA1GeneProduct417563 (Entrez Gene)
RPA3GeneProduct420578 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct395958 (Entrez Gene)
UBCGeneProduct396425 (Entrez Gene)
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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