IL-2 Signaling Pathway (Gallus gallus)

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DPhosphorylationCYCY -> NUInhibitionDDDAcetylationEndoplasmic reticulumMolecular associationSumoylationAccession Number: NetPath 14CY -> NUTranslocationDENNucleusNucleusMethylationGOCY -> NUMTEnzyme complexGlycosylationERProteolytic cleavageAutophosphorylationDeubiquitinationDUbiquitinationDesumoylationNUGolgi apparatusCY -> NUMT(Protein-protein interaction)CY -> NUDCY -> NUDNUPMControlDLigandDDeacetylationMolecule in the pathwayDProteins in a complex interactionCY -> PMReceptorDephosphorylationActivationPalmitolyationMitochondrionReactions through unknown mechanisms/moleculesCytoplasmDemethylationExtracellularRecruitmentCY -> NUCY -> NUDPhosphorylationPM -> CYEndosomeGene SymbolPlasma membraneECSTAT5APIK3R2PTPN11SHBPTK2BYBX1ICAM1AKT1CD53IL2RAMAPK9YBX1SOS1JAK2AKT1MKNK1FYNRELAGRB2ETS1LYNIL2BCL2RELANFKB1NR3C1PIK3CBLCKNFKB1RCJMB04_19o18MAPK3PTPN6MAPK3IRS2GAB2EIF3S9ITM2BAKT1IFNA1IL2VAV1MAPK8IL2TERTSOCS3IL2RGSTAT5BSOCS1TERTCRKPIK3CDSTAMIL2CBLPLCB1PRKCZSTAT5BIL2RBSHC1RCJMB04_17i9FRAP1EIF4EIRS1GNB2L1STAT3RAF1MAPKAPK2ETS2MAPK1PIK3CGHSPCAPIK3R1STAT5AJAK3CREB1NMICRKLCRKRCJMB04_4j14IL2KRASCISHRCJMB04_19h23MAP2K1MAP2K2MAPK1FOXO3STAM2JAK1MAPK14PIK3CARAF1


Description

IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at NetSlim database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 75% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
89850view12:17, 6 October 2016Mkutmonremove GenMAPP notes
89846view12:16, 6 October 2016MkutmonModified description
73858view00:58, 26 February 2014MaintBotupdated schema
67371view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
40924view22:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
35782view06:20, 13 February 2010MaintBotAdded description
33855view17:43, 9 December 2009MaintBotAutomatic update of empty xrefs
31491view21:29, 13 August 2009MaintBotFixed text labels
30316view20:41, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct395928 (Entrez Gene)
BCL2GeneProduct396282 (Entrez Gene)
CBLGeneProduct374038 (Entrez Gene)
CD53GeneProduct
CISHGeneProduct395335 (Entrez Gene)
CREB1GeneProduct395099 (Entrez Gene)
CRKGeneProduct417553 (Entrez Gene)
CRKLGeneProduct416939 (Entrez Gene)
EIF3S9GeneProduct
EIF4EGeneProduct422703 (Entrez Gene)
ETS1GeneProduct768354 (Entrez Gene)
ETS2GeneProduct396250 (Entrez Gene)
FOXO3GeneProduct421769 (Entrez Gene)
FRAP1GeneProduct419455 (Entrez Gene)
FYNGeneProduct396294 (Entrez Gene)
GAB2GeneProduct419027 (Entrez Gene)
GNB2L1GeneProduct417044 (Entrez Gene)
GRB2GeneProduct386572 (Entrez Gene)
HSPCAGeneProduct
ICAM1GeneProduct
IFNA1GeneProduct
IL2GeneProduct373958 (Entrez Gene)
IL2RAGeneProduct395294 (Entrez Gene)
IL2RBGeneProduct
IL2RGGeneProduct395199 (Entrez Gene)
IRS1GeneProduct429126 (Entrez Gene)
IRS2GeneProduct428017 (Entrez Gene)
ITM2BGeneProduct395969 (Entrez Gene)
JAK1GeneProduct395681 (Entrez Gene)
JAK2GeneProduct374199 (Entrez Gene)
JAK3GeneProduct395845 (Entrez Gene)
KRASGeneProduct418207 (Entrez Gene)
LCKGeneProduct
LYNGeneProduct421127 (Entrez Gene)
MAP2K1GeneProduct415549 (Entrez Gene)
MAP2K2GeneProduct396349 (Entrez Gene)
MAPK1GeneProduct373953 (Entrez Gene)
MAPK14GeneProduct421183 (Entrez Gene)
MAPK3GeneProduct
MAPK8GeneProduct423778 (Entrez Gene)
MAPK9GeneProduct395983 (Entrez Gene)
MAPKAPK2GeneProduct419847 (Entrez Gene)
MKNK1GeneProduct771961 (Entrez Gene)
NFKB1GeneProduct396033 (Entrez Gene)
NMIGeneProduct424314 (Entrez Gene)
NR3C1GeneProduct416343 (Entrez Gene)
PIK3CAGeneProduct424971 (Entrez Gene)
PIK3CBGeneProduct424826 (Entrez Gene)
PIK3CDGeneProduct419444 (Entrez Gene)
PIK3CGGeneProduct417706 (Entrez Gene)
PIK3R1GeneProduct427171 (Entrez Gene)
PIK3R2GeneProduct771142 (Entrez Gene)
PLCB1GeneProduct427687 (Entrez Gene)
PRKCZGeneProduct419399 (Entrez Gene)
PTK2BGeneProduct421998 (Entrez Gene)
PTPN11GeneProduct395815 (Entrez Gene)
PTPN6GeneProduct427947 (Entrez Gene)
RAF1GeneProduct396245 (Entrez Gene)
RCJMB04_17i9GeneProduct424044 (Entrez Gene)
RCJMB04_19h23GeneProduct423669 (Entrez Gene)
RCJMB04_19o18GeneProduct427272 (Entrez Gene)
RCJMB04_4j14GeneProduct417637 (Entrez Gene)
RELAGeneProduct
SHBGeneProduct427280 (Entrez Gene)
SHC1GeneProduct395934 (Entrez Gene)
SOCS1GeneProduct416630 (Entrez Gene)
SOCS3GeneProduct395299 (Entrez Gene)
SOS1GeneProduct425964 (Entrez Gene)
STAM2GeneProduct424317 (Entrez Gene)
STAMGeneProduct420517 (Entrez Gene)
STAT3GeneProduct420027 (Entrez Gene)
STAT5AGeneProduct
STAT5BGeneProduct395556 (Entrez Gene)
TERTGeneProduct420972 (Entrez Gene)
VAV1GeneProduct
YBX1GeneProduct386575 (Entrez Gene)

Annotated Interactions

No annotated interactions
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