Integrin-mediated cell adhesion (Rattus norvegicus)

From WikiPathways

Jump to: navigation, search
1PI3KERKECMCAPNITGBcell proliferationPhosphatidylinositiolRAFF-actinp130 Cascell maintenanceITGAIntegrin betaMEKF-actinC3GIntegrin alphaPAKcell maintenancesignaling systemcell motilityCAPNPAKMap2k5Capn1Cav2SrcItgavArafAkt2Cav3SrcCAPN10Itgb6ItgaxSos1Akt1HrasItga4Rock1Capn5CskMYO-PMapk4Pdpk1Pak3BrafITGB3Vav3Rac1Shc1Capn11Capn6MYOCapn7ITGAERAPGEF1Itgb2Itga7Mapk12Akt3Itgb1PxnFynRGD1564327ItgadItga9Itga5RhoItga2LOC685269Capns1Git2Sepp1Mapk10MAPK7Vav2Sorbs1Rac2p110Ptk2Capn2Map2k3ItgamVclCapn9Rock2Itgb8Map2k2Shc3Grb2Tln1Bcar1Itga1Itgb4CDC42ZyxItga10Mapk1PI5KRaf1CrkMap2k6IlkMapk6Map2k1RAC3ACTNRap1bTns1VaspITGB5Pak6Capn3Pak4Rap1aPtk2Itga11Pak2ItgalCav1Arhgef7Itgb7Itga3Pak1Pik3r2Dock1Mylk2Itga6


Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP185(r21067) with a 87% conversion rate.

Quality Tags

Ontology Terms



  1. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed Europe PMC Scholia


View all...
109429view09:29, 17 March 2020L DupuisConnected line
109389view15:54, 16 March 2020L DupuisFixed interactions
71792view20:33, 17 October 2013MaintBotAutomated update of data sources
71302view16:59, 17 October 2013MaintBotAutomated update of data sources
69410view19:01, 8 July 2013MaintBotUpdated to 2013 gpml schema
67403view10:57, 26 June 2013DdiglesOntology Term : 'integrin mediated signaling pathway' added !
62848view05:05, 3 May 2013MaintBotUpdated UniProt data source
41732view02:39, 2 March 2011MaintBotRemoved redundant pathway information and comments
35604view15:47, 12 February 2010ThomasModified description
35597view15:44, 12 February 2010Thomasadded literature
34107view19:22, 9 December 2009MaintBotAutomatic update of empty xrefs
33430view14:55, 30 November 2009MaintBotRemoved group label
31010view01:04, 30 July 2009MaintBotConverted from Homo sapiens
20833view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Integrin-mediated cell adhesion KEGG]] moved to [[Pathway:WP74]]: Moved to stable identifier
8222view13:46, 7 January 2008MaintBot[[Pathway:Rat:Integrin-mediated cell adhesion KEGG]] moved to [[Pathway:Rattus norvegicus:Integrin-mediated cell adhesion KEGG]]: Renaming species
7731view16:13, 18 December 2007MaintBotfixed category names
7270view12:41, 4 November 2007MaintBotAdded categories to GPML
6569view22:20, 22 May 2007169.230.77.174gpml file for [[Rat:Integrin-mediated_cell_adhesion_KEGG]]

External references


View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene) AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
Akt2GeneProduct25233 (Entrez Gene) AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
Akt3GeneProduct29414 (Entrez Gene) AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
ArafGeneProduct64363 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
Arhgef7GeneProduct114559 (Entrez Gene) ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
Bcar1GeneProduct25414 (Entrez Gene) BCAR1; breast cancer anti-estrogen resistance 1
BrafGeneProduct114486 (Entrez Gene) BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAPN10GeneProduct63834 (Entrez Gene) CAPN10; calpain 10 [EC:
CDC42GeneProduct64465 (Entrez Gene) CDC42; cell division cycle 42 (GTP binding protein 25kD)
Capn11GeneProduct408218 (Entrez Gene) CAPN11; calpain 11 [EC:]
Capn1GeneProduct29153 (Entrez Gene) CAPN1; calpain 1 (mu/I) large subunit [EC:]
Capn2GeneProduct29154 (Entrez Gene) CAPN2; calpain 2 (m/II) large subunit [EC:]
Capn3GeneProduct29155 (Entrez Gene) CAPN3; calpain 3 (p94) [EC:]
Capn5GeneProduct171495 (Entrez Gene) CAPN5; calpain
Capn6GeneProduct83685 (Entrez Gene) CAPN6; calpain 6 [EC:]
Capn7GeneProduct306260 (Entrez Gene) CAPN7; calpain 7 [EC:
Capn9GeneProduct116694 (Entrez Gene) CAPN9; calpain 9 (nCL-4) [EC:
Capns1GeneProduct29156 (Entrez Gene) CAPNS1; calpain small subunit 1 [EC:]
Cav1GeneProduct25404 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
Cav2GeneProduct363425 (Entrez Gene) CAV2; caveolin 2
Cav3GeneProduct29161 (Entrez Gene) CAV3; caveolin 3
CrkGeneProduct54245 (Entrez Gene) CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CskGeneProduct315707 (Entrez Gene) CSK; c-src tyrosine kinase [EC:]
Dock1GeneProduct309081 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
FynGeneProduct25150 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:]
Git2GeneProduct304546 (Entrez Gene) GIT2; G protein-coupled receptor kinase-interactor 2
Grb2GeneProduct81504 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
HrasGeneProduct293621 (Entrez Gene)
ITGAEGeneProduct83577 (Entrez Gene)
ITGB3GeneProduct29302 (Entrez Gene)
ITGB5GeneProduct257645 (Entrez Gene)
IlkGeneProduct170922 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
Itga10GeneProduct310683 (Entrez Gene)
Itga11GeneProduct315744 (Entrez Gene)
Itga1GeneProduct25118 (Entrez Gene)
Itga2GeneProduct170921 (Entrez Gene)
Itga3GeneProduct360606 (Entrez Gene)
Itga4GeneProduct311144 (Entrez Gene)
Itga5GeneProduct315346 (Entrez Gene)
Itga6GeneProduct114517 (Entrez Gene)
Itga7GeneProduct81008 (Entrez Gene)
Itga9GeneProduct685004 (Entrez Gene)
ItgadGeneProduct64350 (Entrez Gene)
ItgalGeneProduct308995 (Entrez Gene)
ItgamGeneProduct25021 (Entrez Gene)
ItgavGeneProduct296456 (Entrez Gene)
ItgaxGeneProduct499271 (Entrez Gene)
Itgb1GeneProduct24511 (Entrez Gene)
Itgb2GeneProduct309684 (Entrez Gene)
Itgb4GeneProduct25724 (Entrez Gene)
Itgb6GeneProduct311061 (Entrez Gene)
Itgb7GeneProduct25713 (Entrez Gene)
Itgb8GeneProduct362800 (Entrez Gene)
LOC685269GeneProduct685269 (Entrez Gene)
MAPK7GeneProduct114509 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
Map2k1GeneProduct170851 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
Map2k2GeneProduct58960 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
Map2k3GeneProduct303200 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
Map2k5GeneProduct29568 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
Map2k6GeneProduct114495 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
Mapk10GeneProduct25272 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
Mapk12GeneProduct60352 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
Mapk4GeneProduct54268 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
Mapk6GeneProduct58840 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
Mylk2GeneProduct117558 (Entrez Gene) MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
Pak1GeneProduct29431 (Entrez Gene) PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
Pak2GeneProduct29432 (Entrez Gene) PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
Pak3GeneProduct29433 (Entrez Gene) PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
Pak4GeneProduct292756 (Entrez Gene) PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
Pak6GeneProduct296078 (Entrez Gene) PAK6; p21(CDKN1A)-activated kinase
Pdpk1GeneProduct81745 (Entrez Gene) PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:]
Pik3r2GeneProduct29741 (Entrez Gene) PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
Ptk2GeneProduct25614 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:
PxnGeneProduct360820 (Entrez Gene) PXN; paxillin
RAC3GeneProductRAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
RAPGEF1GeneProduct63881 (Entrez Gene) GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RGD1564327GeneProduct364786 (Entrez Gene)
Rac1GeneProduct363875 (Entrez Gene) RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
Rac2GeneProduct366957 (Entrez Gene) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
Raf1GeneProduct24703 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
Rap1aGeneProduct295347 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
Rap1bGeneProduct171337 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
RhoGeneProduct24717 (Entrez Gene) RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
Rock1GeneProduct81762 (Entrez Gene) ROCK1; Rho-associated coiled-coil containing protein kinase
Rock2GeneProduct25537 (Entrez Gene) ROCK2; Rho-associated coiled-coil containing protein kinase
Sepp1GeneProduct29360 (Entrez Gene) SEPP1; selenoprotein P plasma
Shc1GeneProduct85385 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
Shc3GeneProduct114858 (Entrez Gene) SHC3; neuronal Sh
Sorbs1GeneProduct686098 (Entrez Gene) SH3D5; SH3-domain protein 5 (ponsin
Sos1GeneProduct313845 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
SrcGeneProduct83805 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
Tln1GeneProduct313494 (Entrez Gene) TLN1; talin 1
Tns1GeneProduct301509 (Entrez Gene) TNS; tensi
VaspGeneProduct361517 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
Vav2GeneProduct296603 (Entrez Gene) VAV2; vav 2 oncogene
Vav3GeneProduct295378 (Entrez Gene) VAV3; vav 3 oncogene
VclGeneProduct305679 (Entrez Gene) VCL; vinculin
ZyxGeneProduct114636 (Entrez Gene) ZYX; zyxin

Annotated Interactions

No annotated interactions
Personal tools