Serotonin Receptor 4/6/7 and NR3C Signaling (Homo sapiens)

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2277, 8311, 26, 57, 92854, 9, 14, 20, 24...36, 802, 5, 35, 39, 47...86, 1023, 23, 31, 46, 51...13, 43, 67, 69, 71...5527, 4481, 104797, 33, 49, 61, 78...5819, 21, 28, 29, 42...12, 3853, 7018, 32, 59, 75, 9330, 4517, 996089, 9040, 82361, 4134, 6456, 63876815, 52, 8462, 976, 8, 50, 74, 983716, 10310, 22, 25, 65, 72...68Cyclic AMPELK4ADCYHTR7HTR6SRFNR3C1MAP2K2BRAFMAPK3HTR4serotoninMAP2K1GNASMAPK1RAP1ACREB1MAPKAPK2ELK1RPS6KRPS6KA5ATF1PKAEGR1


This pathway is courtesy of Ariadne Genomics Pathway Studio. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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  1. Lee HJ, Mignacca RC, Sakamoto KM; ''Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133.''; J Biol Chem, 1995 PubMed Europe PMC
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  5. Krump E, Sanghera JS, Pelech SL, Furuya W, Grinstein S; ''Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils.''; J Biol Chem, 1997 PubMed Europe PMC
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  24. Suzaki Y, Yoshizumi M, Kagami S, Koyama AH, Taketani Y, Houchi H, Tsuchiya K, Takeda E, Tamaki T; ''Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults.''; J Biol Chem, 2002 PubMed Europe PMC
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  33. Obara S, Yamada K, Yoshimura Y, Shimoyama M; ''Evidence for the endogenous GTP-dependent ADP-ribosylation of the alpha-subunit of the stimulatory guanyl-nucleotide-binding protein concomitant with an increase in basal adenylyl cyclase activity in chicken spleen cell membrane.''; Eur J Biochem, 1991 PubMed Europe PMC
  34. Rossant CJ, Pinnock RD, Hughes J, Hall MD, McNulty S; ''Corticotropin-releasing factor type 1 and type 2alpha receptors regulate phosphorylation of calcium/cyclic adenosine 3',5'-monophosphate response element-binding protein and activation of p42/p44 mitogen-activated protein kinase.''; Endocrinology, 1999 PubMed Europe PMC
  35. Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV; ''Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.''; J Biol Chem, 2001 PubMed Europe PMC
  36. Baker LP, Nielsen MD, Impey S, Metcalf MA, Poser SW, Chan G, Obrietan K, Hamblin MW, Storm DR; ''Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor.''; J Biol Chem, 1998 PubMed Europe PMC
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  38. Ravanti L, Heino J, L�pez-Ot�n C, K�h�ri VM; ''Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase.''; J Biol Chem, 1999 PubMed Europe PMC
  39. Tao J, Sanghera JS, Pelech SL, Wong G, Levy JG; ''Stimulation of stress-activated protein kinase and p38 HOG1 kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative.''; J Biol Chem, 1996 PubMed Europe PMC
  40. Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD; ''Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.''; Mol Cell Biol, 2005 PubMed Europe PMC
  41. Duan WR, Ito M, Park Y, Maizels ET, Hunzicker-Dunn M, Jameson JL; ''GnRH regulates early growth response protein 1 transcription through multiple promoter elements.''; Mol Endocrinol, 2002 PubMed Europe PMC
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  43. Eblen ST, Slack JK, Weber MJ, Catling AD; ''Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes.''; Mol Cell Biol, 2002 PubMed Europe PMC
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  45. Chibalin AV, Lopina OD, Petukhov SP, Vasilets LA; ''Phosphorylation of the Na,K-ATPase by Ca,phospholipid-dependent and cAMP-dependent protein kinases. Mapping of the region phosphorylated by Ca,phospholipid-dependent protein kinase.''; J Bioenerg Biomembr, 1993 PubMed Europe PMC
  46. Soroka V, Kiryushko D, Novitskaya V, Ronn LC, Poulsen FM, Holm A, Bock E, Berezin V; ''Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule.''; J Biol Chem, 2002 PubMed Europe PMC
  47. Coxon PY, Rane MJ, Uriarte S, Powell DW, Singh S, Butt W, Chen Q, McLeish KR; ''MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.''; Cell Signal, 2003 PubMed Europe PMC
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  51. Budnik LT, Brunswig-Spickenheier B, Mukhopadhyay AK; ''Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway?''; Mol Endocrinol, 2003 PubMed Europe PMC
  52. Ino H, Chiba T; ''Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo.''; J Neurosci, 2001 PubMed Europe PMC
  53. Lindecke A, Korte M, Zagrebelsky M, Horejschi V, Elvers M, Widera D, Pr�llage M, Pfeiffer J, Kaltschmidt B, Kaltschmidt C; ''Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1.''; Eur J Neurosci, 2006 PubMed Europe PMC
  54. Barry OP, Mullan B, Sheehan D, Kazanietz MG, Shanahan F, Collins JK, O'Sullivan GC; ''Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent.''; J Biol Chem, 2001 PubMed Europe PMC
  55. Pindon A, van Hecke G, van Gompel P, Lesage AS, Leysen JE, Jurzak M; ''Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins.''; Mol Pharmacol, 2002 PubMed Europe PMC
  56. Ahmed I, Gesty-Palmer D, Drezner MK, Luttrell LM; ''Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.''; Mol Endocrinol, 2003 PubMed Europe PMC
  57. Waas WF, Dalby KN; ''Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2.''; J Biol Chem, 2002 PubMed Europe PMC
  58. Janknecht R, Hunter T; ''Convergence of MAP kinase pathways on the ternary complex factor Sap-1a.''; EMBO J, 1997 PubMed Europe PMC
  59. Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH; ''TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related.''; J Immunol, 1999 PubMed Europe PMC
  60. Morrison PF, Morishige GM, Beagles KE, Heyes MP; ''Quinolinic acid is extruded from the brain by a probenecid-sensitive carrier system: a quantitative analysis.''; J Neurochem, 1999 PubMed Europe PMC
  61. L�pez Bernal A, Rivera J, Europe-Finner GN, Phaneuf S, Asb�th G; ''Parturition: activation of stimulatory pathways or loss of uterine quiescence?''; Adv Exp Med Biol, 1995 PubMed Europe PMC
  62. Casper-Lindley C, Dahlbeck D, Clark ET, Staskawicz BJ; ''Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC
  63. Papin C, Denouel-Galy A, Laugier D, Calothy G, Eych�ne A; ''Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf.''; J Biol Chem, 1998 PubMed Europe PMC
  64. Bading H; ''Transcription-dependent neuronal plasticity the nuclear calcium hypothesis.''; Eur J Biochem, 2000 PubMed Europe PMC
  65. Wesselborg S, Bauer MK, Vogt M, Schmitz ML, Schulze-Osthoff K; ''Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways.''; J Biol Chem, 1997 PubMed Europe PMC
  66. Wall NR, Mohammad RM, Al-Katib AM; ''Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh.''; Cell Growth Differ, 2001 PubMed Europe PMC
  67. Huber-Lang MS, Younkin EM, Sarma JV, McGuire SR, Lu KT, Guo RF, Padgaonkar VA, Curnutte JT, Erickson R, Ward PA; ''Complement-induced impairment of innate immunity during sepsis.''; J Immunol, 2002 PubMed Europe PMC
  68. Gupta P, Prywes R; ''ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression.''; J Biol Chem, 2002 PubMed Europe PMC
  69. Banihashemi B, Albert PR; ''Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.''; Mol Endocrinol, 2002 PubMed Europe PMC
  70. Russell DL, Doyle KM, Gonzales-Robayna I, Pipaon C, Richards JS; ''Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1,and early growth response factor-1.''; Mol Endocrinol, 2003 PubMed Europe PMC
  71. Chu CT, Levinthal DJ, Kulich SM, Chalovich EM, DeFranco DB; ''Oxidative neuronal injury. The dark side of ERK1/2.''; Eur J Biochem, 2004 PubMed Europe PMC
  72. Azuma N, Akasaka N, Kito H, Ikeda M, Gahtan V, Sasajima T, Sumpio BE; ''Role of p38 MAP kinase in endothelial cell alignment induced by fluid shear stress.''; Am J Physiol Heart Circ Physiol, 2001 PubMed Europe PMC
  73. B�langer LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J; ''Mek2 is dispensable for mouse growth and development.''; Mol Cell Biol, 2003 PubMed Europe PMC
  74. Graf K, Xi XP, Yang D, Fleck E, Hsueh WA, Law RE; ''Mitogen-activated protein kinase activation is involved in platelet-derived growth factor-directed migration by vascular smooth muscle cells.''; Hypertension, 1997 PubMed Europe PMC
  75. Yang E, Lerner L, Besser D, Darnell JE Jr; ''Independent and cooperative activation of chromosomal c-fos promoter by STAT3.''; J Biol Chem, 2003 PubMed Europe PMC
  76. Morgan MA, Dolp O, Reuter CW; ''Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling.''; Blood, 2001 PubMed Europe PMC
  77. Gosmanov AR, Wong JA, Thomason DB; ''Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle.''; Am J Physiol Cell Physiol, 2002 PubMed Europe PMC
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  80. Andressen KW, Norum JH, Levy FO, Krobert KA; ''Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression.''; Mol Pharmacol, 2006 PubMed Europe PMC
  81. New L, Jiang Y, Han J; ''Regulation of PRAK subcellular location by p38 MAP kinases.''; Mol Biol Cell, 2003 PubMed Europe PMC
  82. Chen DB, Westfall SD, Fong HW, Roberson MS, Davis JS; ''Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells.''; Endocrinology, 1998 PubMed Europe PMC
  83. Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z; ''ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons.''; J Biol Chem, 2002 PubMed Europe PMC
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  92. Guha M, O'Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, Stern D, Mackman N; ''Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.''; Blood, 2001 PubMed Europe PMC
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  96. Pomerance M, Abdullah HB, Kamerji S, Correze C, Blondeau JP; ''Thyroid-stimulating hormone and cyclic AMP activate p38 mitogen-activated protein kinase cascade. Involvement of protein kinase A, rac1, and reactive oxygen species.''; J Biol Chem, 2000 PubMed Europe PMC
  97. Peters EP, Wilderspin AF, Wood SP, Zvelebil MJ, Sezer O, Danchin A; ''A pyruvate-stimulated adenylate cyclase has a sequence related to the fes/fps oncogenes and to eukaryotic cyclases.''; Mol Microbiol, 1991 PubMed Europe PMC
  98. Traub O, Monia BP, Dean NM, Berk BC; ''PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells.''; J Biol Chem, 1997 PubMed Europe PMC
  99. Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U, Gaestel M; ''Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.''; J Biol Chem, 1995 PubMed Europe PMC
  100. Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P; ''Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.''; EMBO J, 1995 PubMed Europe PMC
  101. Papin C, Eych�ne A, Brunet A, Pag�s G, Pouyss�gur J, Calothy G, Barnier JV; ''B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.''; Oncogene, 1995 PubMed Europe PMC
  102. Hassler M, Richmond TJ; ''The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.''; EMBO J, 2001 PubMed Europe PMC
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106485view21:40, 4 September 2019KhanspersModified description
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74438view06:47, 20 April 2014EgonwRemoved brackets and text from PubMed IDs, e.g. "10542136 The " changed to "10542136".
70102view18:49, 12 July 2013MaintBotupdated to 2013 schema
49544view10:12, 20 July 2012AndraWp tidy
46089view02:26, 15 December 2011AllanKuchinskyupdated HGNC IDs
45037view18:51, 6 October 2011ThomasOntology Term : 'neuron' added !
45028view18:45, 6 October 2011ThomasOntology Term : 'serotonin signaling pathway' added !
41156view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
39769view07:55, 17 January 2011AlexanderPico
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External references


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NameTypeDatabase referenceComment
ADCYGeneProductAdenylate cyclase
ATF1GeneProduct466 (Entrez Gene) activating transcription factor 1
BRAFGeneProduct673 (Entrez Gene) v-raf murine sarcoma viral oncogene homolog B1
CREB1GeneProduct1385 (Entrez Gene) cAMP response element-binding protein 1
Cyclic AMPMetabolite60-92-4 (CAS)
EGR1GeneProduct1958 (Entrez Gene) early growth response protein
ELK1GeneProduct2002 (Entrez Gene) ELK1, member of ETS oncogene family
ELK4GeneProduct2005 (Entrez Gene) ETS domain-containing protein Elk-4 (SRF accessory protein 1)
GNASGeneProduct2778 (Entrez Gene) GNAS (guanine nucleotide binding protein, alpha stimulating)
HTR4GeneProduct3360 (Entrez Gene) 5 hydroxytryptamine (serotonin) receptor 4
HTR6GeneProduct3362 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 6
HTR7GeneProduct3363 (Entrez Gene) 5-hydroxytryptamine (serotonin) receptor 7
MAP2K1GeneProduct5604 (Entrez Gene) mitogen activated protein kinase kinase 1
MAP2K2GeneProduct5605 (Entrez Gene) mitogen activated protein kinase kinase 2
MAPK1GeneProductMAPK1 (HGNC) mitogen activated protein kinase 1
MAPK3GeneProduct5595 (Entrez Gene) mitogen activated protein kinase 3
MAPKAPK2GeneProduct9261 (Entrez Gene) MAP kinase-activated protein kinase 2
NR3C1GeneProduct2908 (Entrez Gene) nuclear receptor, subfamily 3, group C, member 1
PKAGeneProductcAMP-dependent protein kinase, protein kinase A
RAP1AGeneProduct5906 (Entrez Gene) RAS-related protein-1a
RPS6KGeneProductribosomal protein S6 kinase
RPS6KA5GeneProduct9252 (Entrez Gene) ribosomal protein S6 kinase, polypeptide 5
SRFGeneProduct6722 (Entrez Gene) serum response factor
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions

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