G Protein Signaling Pathways (Rattus norvegicus)

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1, 2CellResponseCytoskeletalChangesProtein Kinase CCellResponseTranscriptionTranscriptionG betaGqGiGscAMPPhosphodiesterasesProtein Kinase AAdenylate CyclasesAKAPsPhosphatase 2BG 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


Description

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.

G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes.

Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP35(r20751) with a 91% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC
  2. Stryer L, Bourne HR; ''G proteins: a family of signal transducers.''; Annu Rev Cell Biol, 1986 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107005view13:46, 17 September 2019MaintBotHMDB identifier normalization
71295view16:57, 17 October 2013MaintBotAutomated update of data sources
69344view18:51, 8 July 2013MaintBotUpdated to 2013 gpml schema
67262view10:28, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway' added !
41656view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
35316view08:17, 12 February 2010ThomasModified description
35314view08:16, 12 February 2010Thomasaddedl literature
34054view19:03, 9 December 2009MaintBotAutomatic update of empty xrefs
33427view14:54, 30 November 2009MaintBotRemoved group label
31485view21:27, 13 August 2009MaintBotFixed text labels
30992view00:57, 30 July 2009MaintBotConverted from Homo sapiens
20831view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:G Protein Signaling]] moved to [[Pathway:WP73]]: Moved to stable identifier
8076view13:46, 7 January 2008MaintBot[[Pathway:Rat:G Protein Signaling]] moved to [[Pathway:Rattus norvegicus:G Protein Signaling]]: Renaming species
7660view16:07, 18 December 2007MaintBotfixed category names
7227view12:41, 4 November 2007MaintBotAdded categories to GPML
19471view22:20, 22 May 2007C.Redferngpml file for [[Rat:G_Protein_Signaling]]
19470view22:20, 22 May 2007BruceConklingpml file for [[Rat:G_Protein_Signaling]]
6549view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:G_Protein_Signaling]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY9GeneProduct302950 (Entrez Gene)
AKAP13GeneProduct293024 (Entrez Gene)
AKAP2GeneProduct298024 (Entrez Gene)
Adcy1GeneProduct305509 (Entrez Gene)
Adcy2GeneProduct81636 (Entrez Gene)
Adcy3GeneProduct64508 (Entrez Gene)
Adcy4GeneProduct54223 (Entrez Gene)
Adcy5GeneProduct64532 (Entrez Gene)
Adcy6GeneProduct25289 (Entrez Gene)
Adcy7GeneProduct84420 (Entrez Gene)
Adcy8GeneProduct29241 (Entrez Gene)
Akap10GeneProduct360540 (Entrez Gene)
Akap1GeneProduct114124 (Entrez Gene)
Akap11GeneProduct498549 (Entrez Gene)
Akap12GeneProduct83425 (Entrez Gene)
Akap3GeneProduct312720 (Entrez Gene)
Akap4GeneProduct79254 (Entrez Gene)
Akap5GeneProduct171026 (Entrez Gene)
Akap6GeneProduct64553 (Entrez Gene)
Akap7GeneProduct361458 (Entrez Gene)
Akap8GeneProduct116633 (Entrez Gene)
Akap9GeneProduct246150 (Entrez Gene)
Arhgef1GeneProduct60323 (Entrez Gene)
CALM1GeneProduct24242 (Entrez Gene)
Ca2+MetaboliteHMDB0000464 (HMDB)
DAGMetaboliteC00165 (KEGG Compound)
GNASGeneProduct24896 (Entrez Gene)
GNG4GeneProduct114118 (Entrez Gene)
Gna11GeneProduct81662 (Entrez Gene)
Gna12GeneProduct81663 (Entrez Gene)
Gna13GeneProduct303634 (Entrez Gene)
Gna14GeneProduct309242 (Entrez Gene)
Gna15GeneProduct89788 (Entrez Gene)
Gnai1GeneProduct25686 (Entrez Gene)
Gnai2GeneProduct81664 (Entrez Gene)
Gnai3GeneProduct25643 (Entrez Gene)
GnalGeneProduct24611 (Entrez Gene)
Gnao1GeneProduct50664 (Entrez Gene)
GnaqGeneProduct81666 (Entrez Gene)
GnazGeneProduct25740 (Entrez Gene)
Gnb1GeneProduct24400 (Entrez Gene)
Gnb2GeneProduct81667 (Entrez Gene)
Gnb3GeneProduct60449 (Entrez Gene)
Gnb5GeneProduct83579 (Entrez Gene)
Gng10GeneProduct114119 (Entrez Gene)
Gng11GeneProduct64199 (Entrez Gene)
Gng12GeneProduct114120 (Entrez Gene)
Gng13GeneProduct685451 (Entrez Gene)
Gng3GeneProduct114117 (Entrez Gene)
Gng5GeneProduct79218 (Entrez Gene)
Gng7GeneProduct58979 (Entrez Gene)
Gng8GeneProduct245986 (Entrez Gene)
Gngt1GeneProduct680149 (Entrez Gene)
Gngt2GeneProduct690825 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
IP3MetaboliteHMDB0001143 (HMDB)
Itpr1GeneProduct25262 (Entrez Gene)
Kcnj3GeneProduct50599 (Entrez Gene)
KrasGeneProduct24525 (Entrez Gene)
NrasGeneProduct24605 (Entrez Gene)
PRKACGGeneProduct
PRKAR1AGeneProduct25725 (Entrez Gene)
Pde1aGeneProduct81529 (Entrez Gene)
Pde1bGeneProduct29691 (Entrez Gene)
Pde1cGeneProduct81742 (Entrez Gene)
Pde4aGeneProduct25638 (Entrez Gene)
Pde4bGeneProduct24626 (Entrez Gene)
Pde4cGeneProduct290646 (Entrez Gene)
Pde4dGeneProduct24627 (Entrez Gene)
Pde7aGeneProduct81744 (Entrez Gene)
Pde7bGeneProduct140929 (Entrez Gene)
Pde8aGeneProduct308776 (Entrez Gene)
Pde8bGeneProduct309962 (Entrez Gene)
Plcb3GeneProduct29322 (Entrez Gene)
Ppp3caGeneProduct24674 (Entrez Gene)
Ppp3ccGeneProduct171378 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
PrkacbGeneProduct293508 (Entrez Gene)
Prkar1bGeneProduct25521 (Entrez Gene)
Prkar2aGeneProduct29699 (Entrez Gene)
Prkar2bGeneProduct24679 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
PrkcdGeneProduct170538 (Entrez Gene)
PrkceGeneProduct29340 (Entrez Gene)
PrkcgGeneProduct24681 (Entrez Gene)
PrkchGeneProduct81749 (Entrez Gene)
PrkciGeneProduct84006 (Entrez Gene)
PrkcqGeneProduct85420 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
Prkd1GeneProduct85421 (Entrez Gene)
Prkd3GeneProduct313834 (Entrez Gene)
RhoaGeneProduct117273 (Entrez Gene)
RrasGeneProduct361568 (Entrez Gene)
Slc9a1GeneProduct24782 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions
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