Estrogen signaling pathway (Homo sapiens)

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1-3NucleusIKK ComplexInhibitionGene expression(Cyc D, IGFR1 etc.)Genomic function of ER (Slow)ActivationGene expression(pS2, Complement 3 etc.)MitochondrionNon-genomic function of ER (fast)MAPKsTranslocationcell proliferation and progressionMTOR signaling etc.Gene expression(anti apoptotic and proliferation)C-FOSSP1EREEstradiolER-AF1ELKERK 1/2ERER-AF2EstradiolGPR30c-JunPI3KEstradiolGrowth factorsNFKBNon-EREBCL2 Apoptotic switchGFRsGNGT1Cyclic AMPGNB1PKB/AktCREBMAPKKKJNKsERGSAp38MAPKKPKACANFKBCREBCHUKERTFIKBKBIKBKG


Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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  1. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia
  2. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  3. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia


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109450view10:10, 18 March 2020L DupuisConverted interactions to graphical lines in legend
106408view21:55, 28 August 2019KhanspersModified description
106173view12:07, 16 August 2019MaintBotHMDB identifier normalization
105588view04:44, 10 August 2019KhanspersModified description
78491view10:28, 7 January 2015MaintBotadded missing graphIds
77341view19:19, 22 August 2014AlexanderPicoModified description
77340view19:18, 22 August 2014AlexanderPicoLinked refs to pathway element
72117view23:15, 24 October 2013AlexanderPicoReplaced IKK node with actual complex of individual nodes
63186view20:45, 8 May 2013MaintBotUpdating gpml version
59090view22:08, 21 February 2013MaintBotUpdated Ensembl data source
48214view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45247view18:33, 7 October 2011AlexanderPicoOntology Term : 'estrogen signaling pathway' added !
41039view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
39752view06:49, 17 January 2011AlexanderPico
38812view08:50, 24 September 2010Jildaunucleus
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External references


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NameTypeDatabase referenceComment
BCL2 Apoptotic switchGeneProduct596 (Entrez Gene)
C-FOSGeneProduct2353 (Entrez Gene)
CHUKGeneProduct1147 (Entrez Gene)
CREBGeneProduct1385 (Entrez Gene)
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
ELKGeneProduct2002 (Entrez Gene)
ER-AF1GeneProduct2099 (Entrez Gene)
ER-AF2GeneProduct2099 (Entrez Gene)
ERGeneProduct2099 (Entrez Gene)
EREGeneProduct2099 (Entrez Gene)
ERK 1/2GeneProductENSG00000100030 (Ensembl)
EstradiolMetaboliteHMDB0000151 (HMDB)
GFRsGeneProduct2099 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
GNGT1GeneProduct2792 (Entrez Gene)
GPR30GeneProduct2852 (Entrez Gene)
GSAGeneProduct2778 (Entrez Gene)
Growth factorsMetaboliteHMDB0000151 (HMDB)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
JNKsGeneProduct5601 (Entrez Gene)
MAPKKGeneProductENSG00000169032 (Ensembl)
MAPKKKGeneProduct673 (Entrez Gene)
NFKBGeneProduct4790 (Entrez Gene)
Non-EREGeneProduct2099 (Entrez Gene)
PI3KGeneProduct5290 (Entrez Gene)
PKACAGeneProduct5566 (Entrez Gene)
PKB/AktGeneProduct207 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
TFGeneProduct2099 (Entrez Gene)
c-JunGeneProduct3725 (Entrez Gene)
p38GeneProduct1432 (Entrez Gene)

Annotated Interactions

No annotated interactions

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