Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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43827627577010941122201151294, 38, 10726942, 86111444116218831, 667112642311336753623379112037666022, 24, 59363712572371207260796233678404840781144078354054, 957854, 957968, 87289579789540787878787895depressionPutative TRsSerotonin SignalingGi signalingBrainstem neuronPutative TRCell MembraneSoma MembranePutative TR2+Sph: SIDS Phenotype Animal ModelSIDS associated polymorphismsGq signalingIncreased relative SIDS expressionK+Putative TRInfant (<1 year in age)4R/4RPutative TRsPutative TRNHSerotoninTransporterTR: Transcriptional Regulation Slowly-Activating K+ CurrentTRrFocal AdhesionsNerve TerminalIncreased long-QT with SIDSPutative TRNa+Putative TRIncreased brainstem hypoplasia with SIDSp+CaSarcoplasmic ReticulumHeartDecreased relative SIDS expressionMiscelaneous SIDS AssociatedK+circadianPutative TRsGs signalingAssociated with Infection and SIDSSPhNucleusVagal ToneBradycardia2SPhBrainStabilizationrs2856966Putative TRHOHNSPhNucleusG5477A BrownAdiposeRapidly-activating K+ CurrentIVS-191_190insAThermoregulationTRrC825TPutative TRsCardiac myocyteSPhOtherAssociated with Energy Metabolism and SIDSSerotonin Synthesis and MetabolismSleepG-proteinSIDS Susceptibility PathwaysPutative TRsPutative TRsPutative TRsG2989T35656971198123246924115TPH2ADCYAP1RUNX3PHOX2AGATA3MIR16-1VIPR1NEUROD1ESR2PPARGC1BKCNQ1CC2D1ARETCHRNA4NGFGNB3CREB1SP1CREBBPMIR13ADEAF15-HTPHES1PKNOX1TP73FEVPPARGC1AFluoxetineNFYATACR1RYR2IL6RESTSCN5APOU3F2MAOAAVPRYR2MEF2CEP300RESTHES1NKX2-2GATA2NFKB1RESTTLX3PHOX2BIL10SP1NFKB1ACADMVIPR25-HIAAMAOADDCC4BHTR1AFOXM1PBX1SP1HIF1AHTR2ATPH1TPH2HIF1ANR3C1IL6RMIR210TCF3KCNH2 YBX1ASCL15-HTRORAL-TryptophanHADHAPLP1CREB1EN1TNFEGR1IL8HSPD1C4ASSTR2DLX2Glial Cell DifferentiationHES5CREB1POU3F2ARTHRBSP1CTCFNicotineNKX3-1JUNADCYAP1ECE1SP3KCNQ1RESTBHLHE40CAV3CDCA7LADCYAP1R1TPH1LMX1BDDCCAV3HTR1AMAZCHRNB4NR3C1SSTR1FEVSLC6A4KCNH25-HT5-HTSP1ALDOAREST124490394911053134610896, 1041710068366532121102498411830521123710566117503133675Putative TRsCTNNB1SOX2NANOGPOU5F15MAPK pathway95BDNFNTRK2Gi signalingGABA83GABRA1CHRM258GJA145SNTA1Na+H+14K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction55SLC9A3CASP3FMO3G6PC6185GCK25GPD1LGRIN1HADHBHTR3A80SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia925-HTGlutamateCa2+106H2OH2OAQP4ApoptosisCPT1AIL1A1016IL1B6IL1RN63IL1389TSPYL1VEGFA7715SCN5A18DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDC98NOS1APGq signalingMAP2TAC141MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamate41SSTTAC141HTR3ATH7682CHAT35114SLC9A3BDNFNTRK295AQP4106GRIN170SP1NFKB299JUN94HDAC973MYBCEBPB5745SNTA1GPD1LSP1JUNNR3C144RESTJUN19CREB1POU2F247CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA183CREB181VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs12536