Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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11488512280464232, 62, 9381121256511810731115571062833, 1177073, 9513626, 25, 543133826086366368319936979782523111919521199782823141516108103421034242, 7742, 771031616165945, 7416591031616241041038442161616Increased long-QT with SIDSHNBradycardiaMiscelaneous SIDS AssociatedG-proteinPutative TRsGs signalingK+Putative TRs Slowly-Activating K+ CurrentTRrSPh BrownAdiposePutative TRsC825TIncreased relative SIDS expressionSerotonin Synthesis and MetabolismNHrs2856966StabilizationSPhPutative TRPutative TRsSIDS associated polymorphismscircadian2+2Infant (<1 year in age)Rapidly-activating K+ CurrentNucleusSph: SIDS Phenotype Animal ModelBrainCardiac myocyteGi signalingNerve TerminalAssociated with Infection and SIDSIVS-191_190insAPutative TRPutative TRNa+Putative TRsSIDS Susceptibility PathwaysPutative TRThermoregulationOtherDecreased relative SIDS expressionG5477AHeartSerotonin SignalingPutative TRsK+SPhTR: Transcriptional RegulationAssociated with Energy Metabolism and SIDSCell MembranePutative TR4R/4RVagal TonePutative TRFocal AdhesionsGq signalingSleepPutative TRsSoma MembraneIncreased brainstem hypoplasia with SIDSp+Sarcoplasmic ReticulumNucleusSerotoninTransporterTRrSPhPutative TRBrainstem neurondepressionG2989THOCa9217469646236618122EP300KCNH2 IL6C4BEN1NR3C1CDCA7LTPH2MIR13AECE1TPH1PLP1POU3F2GNB3HSPD1IL6RC4AHIF1ATPH1ADCYAP1R1RESTDDCKCNQ1RORACREB1MAZFluoxetineCC2D1A5-HTRESTNKX3-1HADHAHTR1AMIR210PPARGC1ANFKB1MAOATLX3NR3C1KCNQ1CTCFHTR1AAVPGlial Cell DifferentiationCREB1DEAF15-HTSSTR2PBX1ALDOAIL10HES1ADCYAP1VIPR1SP1YBX1RESTMEF2CSP1L-TryptophanSCN5ACREB1SP1ADCYAP1PKNOX1RESTCAV3HTR2AFEVSSTR1PPARGC1BTPH2SP1NGFRYR2NEUROD1NFKB1TNFVIPR2EGR1NicotineTP73GATA2GATA3DDCTACR1RETMAOAMIR16-1JUNCREBBPCHRNA4SP1PHOX2BIL8ARNFYAHES5ASCL1NKX2-25-HIAAKCNH2POU3F2HIF1ATHRBCAV3RYR2SLC6A4ACADMTCF3PHOX2ARUNX3HES1REST5-HTPDLX2BHLHE40CHRNB4FOXM15-HTFEVLMX1BSP3ESR282110311478433710053151171058969624540115113761099810929124473361983919, 11612171Putative TRsCTNNB1SOX2NANOGPOU5F171MAPK pathway42BDNFNTRK2Gi signalingGABAGABRA1112123CHRM2GJA118SNTA1Na+H+49K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction11SLC9A3CASP3FMO335G6PCGCK44GPD1L66GRIN1HADHBHTR3A102SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia275-HTGlutamateCa2+34H2OH2OAQP4ApoptosisCPT1A94IL1A120IL1B120IL1RN67IL1358TSPYL157VEGFASCN5A4830DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDCNOS1AP75Gq signalingMAP22TAC1MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamateSST22TAC1HTR3ATH51CHAT8810484SLC9A3BDNF42NTRK234AQP44GRIN1SP1101NFKB2JUN20HDAC9MYB79CEBPB80SNTA118GPD1LSP1JUNNR3C1REST11826JUNCREB1POU2F250CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA1112CREB156VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs9931