Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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1148851228046428132, 62, 93107118125122810676255111333, 11773, 95137065526, 25, 545331198236686311997828652413660313197199731318282991031035942161031616844216161616241659164242, 7745, 741031031642, 77104108Putative TRSerotoninTransporterAssociated with Infection and SIDSSPhC825TTR: Transcriptional RegulationCardiac myocyteBrainstem neuronPutative TRs2+SPhCaIncreased relative SIDS expressionNucleusBrainTRr4R/4RK+G5477AIncreased long-QT with SIDSCell MembraneSPhSerotonin SignalingPutative TRIncreased brainstem hypoplasia with SIDSIVS-191_190insAPutative TRVagal ToneSoma MembranePutative TRsPutative TRMiscelaneous SIDS AssociatedTRrSph: SIDS Phenotype Animal ModelPutative TRsHNPutative TRNerve TerminalInfant (<1 year in age)SPhAssociated with Energy Metabolism and SIDSHeartFocal AdhesionsRapidly-activating K+ CurrentG-proteincircadianPutative TRsHOPutative TRsDecreased relative SIDS expressionOtherSIDS associated polymorphismsG2989TPutative TRsdepressionGq signaling BrownAdiposep+Putative TRNucleusStabilizationPutative TRsNHBradycardiars2856966SIDS Susceptibility PathwaysGs signalingSleepPutative TR Slowly-Activating K+ CurrentGi signalingK+ThermoregulationSerotonin Synthesis and MetabolismSarcoplasmic ReticulumNa+24661762392964681221KCNH2PPARGC1A5-HTVIPR2HADHAFEVNFYAPHOX2BCREBBPEN1FOXM1ALDOARESTSCN5APOU3F2DDCHTR2ASP15-HTLMX1BTCF3NFKB1PPARGC1BMAOAIL6SP1SP3SSTR2SP1DEAF1CTCFSP1IL8FEVRESTSLC6A4MAZTPH1ESR2NFKB1GNB3KCNQ1GATA2IL6RTHRBHES5PHOX2AHIF1ANGFCAV3RYR25-HTPCC2D1AEGR1NKX2-2CHRNA4CREB1RESTHSPD1AVPGATA3POU3F2RYR2MIR13AHTR1AC4BRETYBX1TACR1RESTDDCMAOAHES1C4AASCL1MIR210ADCYAP15-HTBHLHE40EP300PKNOX1RESTTPH2TPH2NKX3-1TP73TLX3VIPR1SSTR1FluoxetineNEUROD1ARPBX1CAV3MIR16-1TPH15-HIAAKCNH2 CDCA7LCHRNB4IL10RORANR3C1PLP1Glial Cell DifferentiationCREB1ADCYAP1R1KCNQ1JUNRUNX3ECE1HIF1ANR3C1MEF2CNicotineCREB1DLX2ADCYAP1HTR1AHES1TNFL-TryptophanSP1ACADM19, 11698451031293311311793747110109613998121105124788976534014691001151582624371Putative TRsCTNNB1SOX2NANOGPOU5F171MAPK pathway42BDNFNTRK2Gi signalingGABAGABRA1112CHRM2123GJA118SNTA1Na+H+49K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction11SLC9A3CASP3FMO3G6PC3544GCKGPD1L66GRIN1HADHBHTR3A102SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia275-HTGlutamateCa2+34H2OH2OAQP4ApoptosisCPT1A94IL1A120IL1B120IL1RNIL136758TSPYL157VEGFA48SCN5A30DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDCNOS1AP75Gq signalingMAP2TAC12MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamate2SST2TAC1HTR3A51THCHAT8810484SLC9A3BDNF42NTRK2AQP434GRIN14SP1101NFKB2JUN20HDAC9MYB79CEBPB80SNTA118GPD1LSP1JUNNR3C1REST118JUN26CREB1POU2F2CREM50RESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA1112CREB156VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs9931