Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways (Homo sapiens)

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21192235119698117651, 6935, 59, 123831107410683013551024, 11564111592726, 49, 571215311092093117881031036241313111720532086312089511094110963919560527295606071, 108959510895951081089595951136079, 1126071, 108951132+Soma MembraneIncreased brainstem hypoplasia with SIDSSerotonin Synthesis and Metabolismrs2856966Putative TRsNucleusAssociated with Infection and SIDSC825T2OtherPutative TRsBradycardiaSarcoplasmic ReticulumHeartPutative TRsRapidly-activating K+ CurrentVagal ToneSerotonin SignalingGq signalingPutative TRCardiac myocyteCell MembraneIncreased long-QT with SIDS BrownAdiposePutative TRPutative TRTRrThermoregulationBrainstem neuronNucleusSPhMiscelaneous SIDS AssociatedSIDS associated polymorphismsGs signalingGi signalingTR: Transcriptional RegulationNHDecreased relative SIDS expressionSPhSPhPutative TRsNerve TerminalK+Putative TRIVS-191_190insAFocal AdhesionsSph: SIDS Phenotype Animal ModelG5477AIncreased relative SIDS expression Slowly-Activating K+ CurrentPutative TRsNa+4R/4RBrainSPhPutative TRCap+HNdepressionAssociated with Energy Metabolism and SIDScircadianPutative TRHOK+G2989TInfant (<1 year in age)Putative TRPutative TRsStabilizationTRrPutative TRsSleepSIDS Susceptibility PathwaysG-proteinSerotoninTransporter12526264777114845637377DLX2PBX1NR3C1RETCHRNA4FOXM1JUNSP1TPH2DEAF1DDCPHOX2BTP73EGR1KCNQ1DDCHES1ECE1MIR13AMEF2CADCYAP1R1CREB1TCF3MIR16-1CAV3MAZESR2RUNX3ASCL1RYR2IL8KCNH2 VIPR2HES1CAV35-HTRESTCREBBPLMX1BKCNQ15-HTPCHRNB4CDCA7LHTR1AC4BRESTNFYAPLP1SP1SLC6A4RESTACADMFEVCREB1ADCYAP1IL6C4AFEV5-HTARTPH1RYR2FluoxetineCTCFGlial Cell DifferentiationTNFHADHAHTR1AL-TryptophanRESTNFKB1POU3F2MAOASP3SSTR1PPARGC1BTLX35-HTSCN5ATACR1SP1IL10KCNH2BHLHE40GNB3EN1NKX3-1NR3C1PKNOX1HSPD1NKX2-2HIF1AYBX1NicotineCC2D1AVIPR15-HIAAHTR2ANFKB1NEUROD1RESTRORACREB1GATA2NGFSSTR2POU3F2TPH2MAOAEP300AVPHES5PPARGC1AMIR210SP1ALDOAIL6RTPH1THRBPHOX2AGATA3ADCYAP1SP1HIF1A79140363110212461811206910780961223468421168778, 93101594899216201029039995166Putative TRsCTNNB1SOX2NANOGPOU5F166MAPK pathway108BDNFNTRK2Gi signalingGABA118GABRA154CHRM2GJA165SNTA1Na+H+43K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivationGAP Junction45SLC9A3CASP3FMO3G6PC4682GCKGPD1L94GRIN1HADHBHTR3A121SCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia335-HTGlutamateCa2+67H2OH2OAQP4ApoptosisCPT1AIL1A32IL1B1717IL1RN18IL1375TSPYL1VEGFA97SCN5A100105DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDC58NOS1APGq signalingMAP298TAC1MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamateSST9898TAC1HTR3ATH2CHAT196391SLC9A3BDNFNTRK210867AQP4GRIN1119SP185NFKB2JUN4HDAC9MYB70CEBPB5SNTA165GPD1LSP1JUNNR3C1REST110104JUNCREB1POU2F27CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRr118GABRA1CREB125VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs5331