Methylation Pathways (Homo sapiens)

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1, 2N-methylationO-methylationS-methylationSAM synthesis (co-substrate)COMTHNMTATPO-methylated substrateS-AdenosylhomocysteineS-methylated substratePhosphateS-AdenosylmethioninePNMTTPMTMAT2BMAT2AS-AdenosylmethionineS-AdenosylhomocysteineS-AdenosylhomocysteineN-methylated substrateL-MethioninePhosphateMAT1ASubstrateNNMTINMTS-Adenosylmethionine


Description

This pathway describes the addition of methyl groups to small molecules. SAM, S-Adenosyl methionine, is utilized as a methyl donor and SAH is produced. This process is important in drug metabolism.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Testa B, Kramer SD; ''The biochemistry of drug metabolism--an introduction: part 4. reactions of conjugation and their enzymes.''; Chem Biodivers, 2008 PubMed Europe PMC
  2. Weinshilboum RM; ''Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase.''; Cell Mol Neurobiol, 2006 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107581view05:35, 23 October 2019KhanspersModified description
107579view05:33, 23 October 2019KhanspersModified description
107578view05:32, 23 October 2019KhanspersModified description
107577view05:32, 23 October 2019KhanspersModified description
107576view05:31, 23 October 2019KhanspersModified description
107575view05:29, 23 October 2019KhanspersModified description
106829view13:30, 17 September 2019MaintBotHMDB identifier normalization
106645view21:07, 12 September 2019KhanspersModified description
105503view05:56, 8 August 2019KhanspersModified description
88909view09:24, 17 August 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
79563view16:07, 25 March 2015ZariChanged ID for INMT gene
68981view17:42, 8 July 2013MaintBotUpdated to 2013 gpml schema
59186view18:51, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
44906view10:26, 6 October 2011MartijnVanIerselOntology Term : 'protein modification pathway' added !
41158view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
39758view07:23, 17 January 2011AlexanderPicomore specific title
33416view14:51, 30 November 2009MaintBotRemoved group label
30265view20:06, 25 July 2009AlexanderPico
30035view10:24, 29 June 2009Pieter GiesbertzAdded literature reference
30033view09:38, 29 June 2009Pieter GiesbertzAdded literature reference
29741view22:38, 1 June 2009KhanspersModified categories
29687view11:37, 27 May 2009Pieter GiesbertzSpecify description
29671view08:09, 26 May 2009Pieter GiesbertzAdded co-substrate synthesis
29349view07:55, 28 April 2009Pieter GiesbertzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetaboliteHMDB0000538 (HMDB)
COMTGeneProductENSG00000093010 (Ensembl)
HNMTGeneProductENSG00000150540 (Ensembl)
INMTGeneProductENSG00000241644 (Ensembl)
L-MethionineMetaboliteHMDB0000696 (HMDB)
MAT1AGeneProductENSG00000151224 (Ensembl)
MAT2AGeneProductENSG00000168906 (Ensembl)
MAT2BGeneProductENSG00000038274 (Ensembl)
N-methylated substrateMetabolite
NNMTGeneProductENSG00000166741 (Ensembl)
O-methylated substrateMetabolite
PNMTGeneProductENSG00000141744 (Ensembl)
PhosphateMetaboliteHMDB0001429 (HMDB)
S-AdenosylhomocysteineMetaboliteHMDB0000939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB0001185 (HMDB)
S-methylated substrateMetabolite
SubstrateMetabolite
TPMTGeneProductENSG00000137364 (Ensembl)

Annotated Interactions

No annotated interactions

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