Trehalose Degradation, Low Osmolarity (Saccharomyces cerevisiae)

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H2Obeta-D-Glucosealpha,alpha-trehalose 6-phosphateH2OH2Oglucose-6-phosphateATH1ATPglycolysisADPphosphateGLK1NTH2TPS2NTH1glucose-6-phosphatetrehalose


Trehalose is a storage carbohydrate that can either be synthesized or obtained from the external environment. To be utilized as a carbon source, trehalase (EC: must convert trehalose and water into two molecules of glucose. S. cerevisiae has two trehalase enzymes, one is an acid trehalase encoded by ATH1 and the other is a neutral trehalase encoded by NTH1. The name "acid" or "neutral" are based on the optimal pH of each enzyme (pH 4.5-5.0 and pH 6.8-7.0, respectively).

Each trehalase enzyme is active in a different subcellular location. Nth1p occurs as homodimer that is located in the cytoplasm, and is required for the hydrolysis of intracellular trehalose. Intracellular trehalose either results from trehalose biosynthesis, or to a lesser degree from uptake of trehalose from the environment via the Mal11p transporter. Ath1p was originally predicted to be a vacuolar protein, but has been experimentally shown to mainly localize in the periplasmic space, with a small fraction also occurring in the cell wall. Extracellular trehalose is hydrolysed into 2 glucose molecules by Ath1p.



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96342view09:26, 9 March 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
94082view12:25, 18 August 2017DeSlAdded annotation for H2O, connect last line.
94071view13:50, 17 August 2017DeSlModified description
94070view13:37, 17 August 2017DeSlModified description
94069view13:36, 17 August 2017DeSlModified description
94068view13:34, 17 August 2017DeSlModified description
94067view13:32, 17 August 2017DeSlModified description
94066view13:31, 17 August 2017DeSlModified description
94065view13:30, 17 August 2017DeSlModified description
94064view13:26, 17 August 2017DeSlModified description
94063view13:21, 17 August 2017DeSlConnected lines, annotated nodes, changed IDs for glucose-6-phosphate (from open to closed structure).
70048view05:57, 12 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69661view20:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67716view11:53, 26 June 2013DdiglesOntology Term : 'trehalose degradation pathway' added !
53719view20:09, 12 November 2012EgonwConnecting dots.
41901view04:53, 2 March 2011MaintBotRemoved redundant pathway information and comments
20825view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Trehalose Degradation Low Osmolarity]] moved to [[Pathway:WP70]]: Moved to stable identifier
12877view08:06, 17 May 2008MaintBotautomated metabolite conversion
8975view14:13, 7 January 2008MaintBotAdded to category $category
8973view14:13, 7 January 2008M.BraymerUploaded new pathway

External references


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NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ATH1GeneProductS000006230 (SGD) For conversion of acid trehalose
ATPMetabolite1927-31-7 (CAS)
GLK1GeneProductS000000545 (SGD)
H2OMetaboliteCHEBI:15377 (ChEBI)
NTH1GeneProductS000002408 (SGD) For c onversion of neutral trehalose
NTH2GeneProductS000000205 (SGD)
TPS2GeneProductS000002481 (SGD)
alpha,alpha-trehalose 6-phosphateMetaboliteCHEBI:58429 (ChEBI)
beta-D-GlucoseMetaboliteCHEBI:15903 (ChEBI)
glucose-6-phosphateMetaboliteCHEBI:75052 (ChEBI)
glucose-6-phosphateMetaboliteCHEBI:75150 (ChEBI)
glycolysisPathwayWP253 (WikiPathways)
phosphateMetabolite14265-44-2 (CAS)
trehaloseMetabolite99-20-7 (CAS)

Annotated Interactions

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