Androgen Receptor Signaling Pathway (Rattus norvegicus)

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1-7EndosomeGene SymbolProteins in a complex interactionAndrogen (T/DHT)ECReceptorAccession Number: NetPath 2; cellmap:2ControlEnzyme complexPalmitoylationGOEndoplasmic reticulumPPMCY->NUNucleusUbiquitinationDRecruitmentERDemethylationDeacetylationPCY->NUPMolecular associationCYPGolgi appparatusCytoplasmDCY->NUGlycosylationNU(Protein-protein interaction)MTDSumoylationPhosphorylationProteolytic CleavageDephosphorylationActivationDInhibitionDeubiquitinationTranslocationCY->NUReactions through unknown mechanisms/moleculesENDDeSumoylationPlasma membraneMitochondrionMethylationAcetylationMolecule in the pathwayPLigandAndrogen IndependentAndrogen IndependentAutophosphorylationExtracellularMyst2Pias3Rchy1Gtf2f1RNF14Smad4YwhahNr0b2Raf1ArJunCcnd1Esr1SRYEsr1Map2k1Brca1Tgfb1i1Casp8UxtSp1FlnaSrcNr3c1Prmt1Casp7Nr2c2Cdc25bNcoa2Pias2Smad3PCAFPias1Pa2g4Senp1CrebbpLOC680054Casp3APPLZNF278Mapk1HMGB2Mdm2Casp1Rad54l2Nsd1Runx1Pou2f2RAC3RASAkt1Ep300Prmt1Gtf2f2Cdc2Cdc37Etv5Slc25a4Igf1ArArEgfrMmp1aPias4Ncoa1RelaCalrNcor2Nr5a1Hipk3PxnNcoa3STUB1Rb1Rchy1HSPA1ARANBP9Kat5GhrCdk7Ctdp1Ube3aCox5bStat3Mapk1Il6Plagl1Ube2iCtnnb1Fhl2Runx2CcnhPnrc1Akt1Tmf1Pou2f1ArAtf2SpdefCcne1AesHdac1JunIl6stGHBPNr3c1Cdk9Gtf2h1Psmc3ipPtenPak6Bag1Cav1Sin3aRanNrip1Tgif1Esr2Nr0b1Tp53Pnrc1Rb1SvilNcoa4FlnaGAPDHRnf4Ar


The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source:


GenMAPP notes 
NetPath:2; cellmap:2 - Androgen Receptor Signaling Pathway. The Androgen Receptor signaling pathway was kindly reviewed by Liying Zhang and William Gerald. This cancer signaling pathway is available at Cancer Cell Map ( and NetPath ( and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (, PandeyLab at Johns Hopkins University ( and Institute of Bioinformatics ( If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks;
This pathway was inferred from Homo sapiens pathway WP138(r20973) with a 90% conversion rate.

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Ontology Terms



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  1. Davison SL, Bell R; ''Androgen physiology.''; Semin Reprod Med, 2006 PubMed Europe PMC Scholia
  2. Bardin CW, Brown T, Isomaa VV, Jänne OA; ''Progestins can mimic, inhibit and potentiate the actions of androgens.''; Pharmacol Ther, 1983 PubMed Europe PMC Scholia
  3. Holterhus PM, Piefke S, Hiort O; ''Anabolic steroids, testosterone-precursors and virilizing androgens induce distinct activation profiles of androgen responsive promoter constructs.''; J Steroid Biochem Mol Biol, 2002 PubMed Europe PMC Scholia
  4. Mooradian AD, Morley JE, Korenman SG; ''Biological actions of androgens.''; Endocr Rev, 1987 PubMed Europe PMC Scholia
  5. Roy AK, Lavrovsky Y, Song CS, Chen S, Jung MH, Velu NK, Bi BY, Chatterjee B; ''Regulation of androgen action.''; Vitam Horm, 1999 PubMed Europe PMC Scholia
  6. Raudrant D, Rabe T; ''Progestogens with antiandrogenic properties.''; Drugs, 2003 PubMed Europe PMC Scholia
  7. Heinlein CA, Chang C; ''The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions.''; Mol Endocrinol, 2002 PubMed Europe PMC Scholia


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81858view15:45, 3 September 2015Nunotesting
71830view19:36, 18 October 2013MaintBotremoved data source from nodes without identifier
67045view09:58, 26 June 2013Christine ChichesterOntology Term : 'androgen signaling pathway' added !
47769view05:27, 6 April 2012Khanspersupdated xref
41757view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
35673view22:47, 12 February 2010AlexanderPico
35671view22:45, 12 February 2010AlexanderPicoadding description and refs
34127view19:28, 9 December 2009MaintBotAutomatic update of empty xrefs
31483view21:26, 13 August 2009MaintBotFixed text labels
30960view00:46, 30 July 2009MaintBotConverted from Homo sapiens
20821view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Androgen-Receptor NetPath 2]] moved to [[Pathway:WP68]]: Moved to stable identifier
7906view13:46, 7 January 2008MaintBot[[Pathway:Rat:Androgen-Receptor NetPath 2]] moved to [[Pathway:Rattus norvegicus:Androgen-Receptor NetPath 2]]: Renaming species
7578view16:01, 18 December 2007MaintBotfixed category names
7197view12:33, 4 November 2007MaintBotAdded categories to GPML
6518view22:19, 22 May 2007A.Pandeygpml file for [[Rat:Androgen-Receptor_NetPath_2]]

External references


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NameTypeDatabase referenceComment
AesGeneProduct29466 (Entrez Gene)
Akt1GeneProduct24185 (Entrez Gene)
ArGeneProduct24208 (Entrez Gene)
Atf2GeneProduct81647 (Entrez Gene)
Bag1GeneProduct297994 (Entrez Gene)
Brca1GeneProduct497672 (Entrez Gene)
CalrGeneProduct64202 (Entrez Gene)
Casp1GeneProduct25166 (Entrez Gene)
Casp3GeneProduct25402 (Entrez Gene)
Casp7GeneProduct64026 (Entrez Gene)
Casp8GeneProduct64044 (Entrez Gene)
Cav1GeneProduct25404 (Entrez Gene)
Ccnd1GeneProduct58919 (Entrez Gene)
Ccne1GeneProduct25729 (Entrez Gene)
CcnhGeneProduct84389 (Entrez Gene)
Cdc2GeneProduct54237 (Entrez Gene)
Cdc25bGeneProduct171103 (Entrez Gene)
Cdc37GeneProduct114562 (Entrez Gene)
Cdk7GeneProduct171150 (Entrez Gene)
Cdk9GeneProduct362110 (Entrez Gene)
Cox5bGeneProduct94194 (Entrez Gene)
CrebbpGeneProduct54244 (Entrez Gene)
Ctdp1GeneProduct291414 (Entrez Gene)
Ctnnb1GeneProduct84353 (Entrez Gene)
EgfrGeneProduct24329 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
Esr1GeneProduct24890 (Entrez Gene)
Esr2GeneProduct25149 (Entrez Gene)
Etv5GeneProduct303828 (Entrez Gene)
Fhl2GeneProduct63839 (Entrez Gene)
FlnaGeneProduct293860 (Entrez Gene)
GAPDHGeneProduct24383 (Entrez Gene)
GhrGeneProduct25235 (Entrez Gene)
Gtf2f1GeneProduct316123 (Entrez Gene)
Gtf2f2GeneProduct81674 (Entrez Gene)
Gtf2h1GeneProduct361580 (Entrez Gene)
HMGB2GeneProduct29395 (Entrez Gene)
HSPA1AGeneProduct24472 (Entrez Gene)
Hdac1GeneProduct297893 (Entrez Gene)
Hipk3GeneProduct83617 (Entrez Gene)
Igf1GeneProduct24482 (Entrez Gene)
Il6GeneProduct24498 (Entrez Gene)
Il6stGeneProduct25205 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
Kat5GeneProduct192218 (Entrez Gene)
LOC680054GeneProduct680054 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mdm2GeneProduct314856 (Entrez Gene)
Mmp1aGeneProduct300339 (Entrez Gene)
Myst2GeneProduct303470 (Entrez Gene)
Ncoa1GeneProduct313929 (Entrez Gene)
Ncoa2GeneProduct83724 (Entrez Gene)
Ncoa3GeneProduct84584 (Entrez Gene)
Ncoa4GeneProduct619385 (Entrez Gene)
Ncor2GeneProduct360801 (Entrez Gene)
Nr0b1GeneProduct58850 (Entrez Gene)
Nr0b2GeneProduct117274 (Entrez Gene)
Nr2c2GeneProduct50659 (Entrez Gene)
Nr3c1GeneProduct24413 (Entrez Gene)
Nr5a1GeneProduct83826 (Entrez Gene)
Nrip1GeneProduct304157 (Entrez Gene)
Nsd1GeneProduct306764 (Entrez Gene)
PCAFGeneProduct301164 (Entrez Gene)
Pa2g4GeneProduct288778 (Entrez Gene)
Pak6GeneProduct296078 (Entrez Gene)
Pias1GeneProduct300772 (Entrez Gene)
Pias2GeneProduct83422 (Entrez Gene)
Pias3GeneProduct83614 (Entrez Gene)
Pias4GeneProduct362827 (Entrez Gene)
Plagl1GeneProduct25157 (Entrez Gene)
Pnrc1GeneProduct286988 (Entrez Gene)
Pou2f1GeneProduct171068 (Entrez Gene)
Pou2f2GeneProduct117058 (Entrez Gene)
Prmt1GeneProduct60421 (Entrez Gene)
Psmc3ipGeneProduct140938 (Entrez Gene)
PtenGeneProduct50557 (Entrez Gene)
PxnGeneProduct360820 (Entrez Gene)
RNF14GeneProduct619577 (Entrez Gene)
Rad54l2GeneProduct363135 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
RanGeneProduct84509 (Entrez Gene)
Rb1GeneProduct24708 (Entrez Gene)
Rchy1GeneProduct289508 (Entrez Gene)
RelaGeneProduct309165 (Entrez Gene)
Rnf4GeneProduct29274 (Entrez Gene)
Runx1GeneProduct50662 (Entrez Gene)
Runx2GeneProduct367218 (Entrez Gene)
SRYGeneProduct25221 (Entrez Gene)
STUB1GeneProduct287155 (Entrez Gene)
Senp1GeneProduct300193 (Entrez Gene)
Sin3aGeneProduct363067 (Entrez Gene)
Slc25a4GeneProduct85333 (Entrez Gene)
Smad3GeneProduct25631 (Entrez Gene)
Smad4GeneProduct50554 (Entrez Gene)
Sp1GeneProduct24790 (Entrez Gene)
SpdefGeneProduct689210 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
SvilGeneProduct361256 (Entrez Gene)
Tgfb1i1GeneProduct84574 (Entrez Gene)
Tgif1GeneProduct316742 (Entrez Gene)
Tmf1GeneProduct114206 (Entrez Gene)
Tp53GeneProduct24842 (Entrez Gene)
Ube2iGeneProduct25573 (Entrez Gene)
Ube3aGeneProduct361585 (Entrez Gene)
UxtGeneProduct299313 (Entrez Gene)
YwhahGeneProduct25576 (Entrez Gene)

Annotated Interactions

No annotated interactions
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