ATM Signaling Pathway (Rattus norvegicus)

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3971151025748DNA RepairG1 Cell ArrestG2 Cell ArrestDNA DamageUV+pApoptoseGenotoxic drugsγ-radiation+p+pCytCE2f1Gadd45aCaspase3Pmaip1AtmBrca1Cdk2H2afxCyclinB1Bcl2BaxCdkn1a14-3-3 sigma Chk2Cyclin DApaf1Bak1E2f1Caspase9ReprimoRb1Rb1Cdk6Cdc2Tp53Cyclin E16


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  1. Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W; ''Histone H2A variants H2AX and H2AZ.''; Curr Opin Genet Dev, 2002 PubMed Europe PMC
  2. Ye Q, Hu YF, Zhong H, Nye AC, Belmont AS, Li R; ''BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.''; J Cell Biol, 2001 PubMed Europe PMC
  3. J�rgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC; ''Bax directly induces release of cytochrome c from isolated mitochondria.''; Proc Natl Acad Sci U S A, 1998 PubMed Europe PMC
  4. Ohki R, Nemoto J, Murasawa H, Oda E, Inazawa J, Tanaka N, Taniguchi T; ''Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase.''; J Biol Chem, 2000 PubMed Europe PMC
  5. Chen L, Gilkes DM, Pan Y, Lane WS, Chen J; ''ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.''; EMBO J, 2005 PubMed Europe PMC
  6. Kothakota S et al; ''Caspase 3-generated fragment of gelsolin: effector of morphological change in apoptosis''; Science 278, 294-298, 1997
  7. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ; ''The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.''; Cell, 1993 PubMed Europe PMC
  8. Starita LM, Parvin JD; ''The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair.''; Curr Opin Cell Biol, 2003 PubMed Europe PMC
  9. Scaife RM; ''G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium.''; Mol Cancer Ther, 2004 PubMed Europe PMC
  10. Zhang ZK, Davies KP, Allen J, Zhu L, Pestell RG, Zagzag D, Kalpana GV; ''Cell cycle arrest and repression of cyclinD1 transcription by INI1/hSNF5.''; Mol Cell Biol, 2002 PubMed Europe PMC
  11. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR; ''Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.''; Science, 2004 PubMed Europe PMC


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72076view19:49, 24 October 2013KhanspersModified title
72058view17:18, 24 October 2013Mkutmonupdated annotation for Apaf1
70122view19:25, 12 July 2013MaintBotupdated to 2013 schema
67770view13:52, 26 June 2013Christine ChichesterOntology Term : 'ATM signaling pathway' added !
67067view10:01, 26 June 2013Christine ChichesterOntology Term : 'p53-dependent G1/S DNA damage checkpoint pathway' added !
58952view18:22, 21 February 2013MaintBotUpdated Ensembl data source
41705view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
33396view14:46, 30 November 2009MaintBotRemoved group label
29974view11:31, 19 June 2009ThomasModified categories
29973view11:30, 19 June 2009Thomasfixed cyclin D reference
29972view11:28, 19 June 2009Thomasfixed literature reference
29970view11:23, 19 June 2009Thomasmerged WP631 into this pathway
29905view12:11, 9 June 2009Thomasupdated ensembl references
28565view10:33, 13 February 2009Thomas
28518view14:13, 11 February 2009RalphStrausPeriodical save, work in progress
28512view14:03, 11 February 2009RalphStrausPeriodical save, work in progress
28506view13:55, 11 February 2009RalphStrausSpecify description
28501view13:52, 11 February 2009RalphStrausPeriodical save, work in progress
28496view13:48, 11 February 2009RalphStrausSpecify description
28491view13:42, 11 February 2009RalphStrausPeriodical save, work in progress
28484view13:31, 11 February 2009RalphStrausSpecify description
28471view13:16, 11 February 2009RalphStrausSpecify description
28468view13:12, 11 February 2009RalphStrausSpecify description
28443view12:46, 11 February 2009RalphStrausPeriodical save, work in progress
28433view12:36, 11 February 2009RalphStrausPeriodical save, work in progress
28424view12:25, 11 February 2009RalphStrausPeriodical save, work in progress
28416view12:15, 11 February 2009RalphStrausPeriodical save, work in progress
28408view12:03, 11 February 2009RalphStrausPeriodical save, work in progress
28398view11:52, 11 February 2009RalphStrausPeriodical save, work in progress
28392view11:42, 11 February 2009RalphStrausNew pathway

External references


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NameTypeDatabase referenceComment
14-3-3 sigma GeneProduct298795 (Entrez Gene)
Apaf1GeneProductENSRNOG00000008022 (Ensembl)
AtmGeneProduct300711 (Entrez Gene)
Bak1GeneProduct116502 (Entrez Gene)
BaxGeneProduct24887 (Entrez Gene)
Bcl2GeneProduct24224 (Entrez Gene)
Brca1GeneProduct497672 (Entrez Gene)
Caspase3GeneProduct25402 (Entrez Gene)
Caspase9GeneProduct58918 (Entrez Gene)
Cdc2GeneProduct54237 (Entrez Gene)
Cdk2GeneProduct362817 (Entrez Gene)
Cdk6GeneProduct114483 (Entrez Gene)
Cdkn1aGeneProductENSRNOG00000000521 (Ensembl)
Chk2GeneProduct114212 (Entrez Gene)
Cyclin DGeneProduct58919 (Entrez Gene)
Cyclin EGeneProduct25729 (Entrez Gene)
CyclinB1GeneProduct25203 (Entrez Gene)
CytCGeneProduct25309 (Entrez Gene)
E2f1GeneProduct399489 (Entrez Gene)
Gadd45aGeneProduct25112 (Entrez Gene)
H2afxGeneProduct300668 (Entrez Gene)
Pmaip1GeneProduct492821 (Entrez Gene)
Rb1GeneProduct24708 (Entrez Gene)
ReprimoGeneProduct680110 (Entrez Gene)
Tp53GeneProduct24842 (Entrez Gene)

Annotated Interactions

No annotated interactions

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