EPO receptor signaling (Homo sapiens)

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The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Source: Wikipedia

This pathway is based on ScienceSlides.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Lacombe C, Mayeux P; ''The molecular biology of erythropoietin.''; Nephrol Dial Transplant, 1999 PubMed Europe PMC Scholia
  2. Zhu Y, D'Andrea AD; ''The molecular physiology of erythropoietin and the erythropoietin receptor.''; Curr Opin Hematol, 1994 PubMed Europe PMC Scholia


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117099view11:31, 17 May 2021EweitzModified title
106394view21:28, 28 August 2019KhanspersModified description
105439view04:51, 8 August 2019KhanspersModified description
86897view07:58, 14 July 2016MkutmonOntology Term : 'oxidative phosphorylation pathway' added !
67199view10:19, 26 June 2013Christine ChichesterOntology Term : 'erythropoietin signaling pathway' added !
63183view20:43, 8 May 2013MaintBotUpdating gpml version
41162view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
35091view12:54, 11 February 2010Thomasadded literature
32158view14:03, 14 August 2009MaintBotFixed group labels
22574view13:25, 14 November 2008ThomasNew pathway

External references


View all...
NameTypeDatabase referenceComment
CD45GeneProduct5788 (Entrez Gene)
CISHGeneProduct1154 (Entrez Gene)
EPOGeneProduct2056 (Entrez Gene)
EPORGeneProduct2057 (Entrez Gene)
ERK1GeneProduct5595 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
MEK1GeneProduct5604 (Entrez Gene)
MEK2GeneProduct5605 (Entrez Gene)
PDK1GeneProduct5163 (Entrez Gene)
PI3KGeneProduct5294 (Entrez Gene)
PKBGeneProduct207 (Entrez Gene)
PTPGeneProduct10076 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RASGeneProduct5921 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)

Annotated Interactions

No annotated interactions

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