Dauer formation (Caenorhabditis elegans)

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TGF-Beta-related pathwaydaf-c (dauer constitutive)mutants always enter dauer stageInsulin-related pathwayCytosolCyclic nucleotide pathwayNucleusdaf-d (dauer-defective)mutants don't enter dauer stage32DAF-12TAX-4DAF-3TAX-2AGE-1/PI3KDAF-16/FOXODafachronic acidDAF-21DAF-9DAF-11DAF-4AKT-1AKT-2DAF-7/TGF-BetaCyclic GMPFTT-2RLE-1DAF-8DAF-5DAF-28/InsulinDAF-16/FOXODAF-18/PTENDAF-14DAF-1DAF-2/InsRPDK-11


From wormbook: In response to harsh environmental conditions, C. elegans larvae undergo dauer arrest at the second molt. The past decade has yielded many insights into the signaling pathways and the molecular mechanisms that govern this developmental transition. Dauer pheromone, the major physiologic signal promoting dauer arrest, has been purified, identified, and synthesized. The molecular identities of the vast majority of dauer regulatory genes isolated in initial genetic screens are now known. Physiologic ligands for DAF-12, a nuclear receptor that is the final common target of dauer regulatory pathways, have been identified. The discovery of the Hid (high temperature induction of dauer) phenotype and the results of enhancer screens have greatly expanded the repertoire of dauer regulatory genes. Genomic analysis of dauer arrest has highlighted the role of pathway crosstalk in dauer regulation. Nonetheless, critical questions remain about the mechanistic underpinnings of dauer arrest.

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  1. Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ; ''Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.''; Cell, 2006 PubMed Europe PMC
  2. Hu PJ; ''Dauer.''; WormBook, 2007 PubMed Europe PMC
  3. Savage-Dunn C; ''TGF-beta signaling.''; WormBook, 2005 PubMed Europe PMC


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106028view11:55, 16 August 2019MaintBotHMDB identifier normalization
87222view14:38, 19 July 2016SusanOntology Term : 'signaling pathway' added !
81165view13:30, 29 July 2015EgonwReplaced the CTD identifier with a ChEBI one via the CAS registry number (sources: ChEBI and https://www.caymanchem.com/app/template/Product.vm/catalog/14101)
68467view20:29, 5 July 2013MaintBotUpdated to 2013 gpml schema
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49054view20:23, 3 July 2012KyookPeriodical save, work in progress
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40621view19:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
32470view17:30, 15 August 2009MaintBotFixed text labels
32157view14:03, 14 August 2009MaintBotFixed group labels
29502view00:13, 11 May 2009AlexanderPicoConverted identifiers to wormbase IDs
22599view13:44, 14 November 2008MartijnVanIerseladded chemspider link
22522view12:48, 14 November 2008MartijnVanIerselModified categories
22519view12:47, 14 November 2008MartijnVanIerselModified description
22517view12:45, 14 November 2008MartijnVanIerselNew pathway

External references


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NameTypeDatabase referenceComment
AGE-1/PI3KGeneProductB0334.8 (WormBase)
AKT-1GeneProductC12D8.10 (WormBase)
AKT-2GeneProductF28H6.1 (WormBase)
Cyclic GMPMetaboliteHMDB0001314 (HMDB)
DAF-11GeneProductB0240.3 (WormBase)
DAF-12GeneProductF11A1.3 (WormBase)
DAF-14GeneProductF01G10.8 (WormBase)
DAF-16/FOXOGeneProductR13H8.1 (WormBase)
DAF-18/PTENGeneProductT07A9.6 (WormBase)
DAF-1GeneProductF29C4.1 (WormBase)
DAF-2/InsRGeneProductY55D5A.5 (WormBase)
DAF-21GeneProductC47E8.5 (WormBase)
DAF-28/InsulinGeneProductY116F11B.1 (WormBase)
DAF-3GeneProductF25E2.5 (WormBase)
DAF-4GeneProductC05D2.1 (WormBase)
DAF-5GeneProductW01G7.1 (WormBase)
DAF-7/TGF-BetaGeneProductB0412.2 (WormBase)
DAF-8GeneProductR05D11.1 (WormBase)
DAF-9GeneProductT13C5.1 (WormBase)
Dafachronic acidMetaboliteCHEBI:71556 (ChEBI)
  • Chemspider link: http://www.chemspider.com/Chemical-Structure.19988767.html
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FTT-2GeneProductF52D10.3 (WormBase)
PDK-1GeneProductH42K12.1 (WormBase)
RLE-1GeneProductM142.6 (WormBase)
TAX-2GeneProductF36F2.5 (WormBase)
TAX-4GeneProductZC84.2 (WormBase)

Annotated Interactions

No annotated interactions

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