Monoamine GPCRs (Homo sapiens)

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AdrenergicReceptorsSerotoninReceptorsMuscarinicAcetylcholine ReceptorsDopamineReceptorsHistamineReceptorsHRH2NorepinephrineCHRM4DRD4Gq/G11 PathwayDRD2CHRM2ADRA2CCHRM1HTR1AHTR1EADRB3HTR7Gs PathwayDRD5HistamineHTR1DMuscarineHTR6DopamineHTR1BCHRM5ADRA2BCHRM3DRD1HTR5BADRA1DHTR4HTR1FADRB2HTR2BSerotoninHTR2CADRA1BHRH1ADRA1AADRA2AGs PathwayEpinephrineADRB1HTR2ADRD3HTR5AGi/Go PathwayAcetylcholine


G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: Wikipedia

Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. Monoamine neurotransmitters

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113950view06:15, 11 December 2020EgonwFour more clickable pathways
107187view14:27, 17 September 2019MaintBotChEBI identifier normalization
106819view13:29, 17 September 2019MaintBotHMDB identifier normalization
96087view19:06, 15 February 2018KhanspersModified description
96084view19:05, 15 February 2018KhanspersModified description
96083view19:05, 15 February 2018KhanspersModified description
96082view19:04, 15 February 2018KhanspersModified description
93101view15:59, 28 July 2017DeSlChanged PubchemSub to chebi for muscarine
80015view15:41, 30 April 2015ZariChanged old ID to new Id for HTR5B
69046view17:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
48221view05:29, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45376view21:26, 7 October 2011KhanspersOntology Term : 'G protein mediated signaling pathway' added !
45142view01:09, 7 October 2011AlexanderPicoadded pathway refs
41233view23:46, 1 March 2011MaintBotRemoved redundant pathway information and comments
38873view18:31, 24 September 2010Khanspers
38823view10:13, 24 September 2010Thomasfixed line positions
38821view10:10, 24 September 2010Thomaslinked pathways
34497view22:42, 16 December 2009KhanspersChanged layout
34479view18:38, 10 December 2009MaintBotAutomatic update of empty xrefs
32469view17:29, 15 August 2009MaintBotFixed text labels
32156view14:03, 14 August 2009MaintBotFixed group labels
20799view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Monoamine GPCRs]] moved to [[Pathway:WP58]]: Moved to stable identifier
14482view00:13, 23 May 2008AlexanderPicoConnected ligands
14473view23:57, 22 May 2008AlexanderPicoConnected!
14470view23:53, 22 May 2008AlexanderPicoPeriodical save, work in progress
14463view23:43, 22 May 2008AlexanderPicoPeriodical save, work in progress
14459view23:33, 22 May 2008AlexanderPicoPeriodical save, work in progress
14457view23:30, 22 May 2008AlexanderPicoGrouped by class and fixed labels
14449view23:10, 22 May 2008AlexanderPicoPeriodical save, work in progress
14447view23:00, 22 May 2008AlexanderPicoPeriodical save, work in progress
13088view11:14, 17 May 2008MaintBotautomated metabolite conversion
12999view11:01, 17 May 2008MaintBotSticky edges patch by Sjoerd
8266view13:46, 7 January 2008MaintBot[[Pathway:Human:Monoamine GPCRs]] moved to [[Pathway:Homo sapiens:Monoamine GPCRs]]: Renaming species
7753view16:15, 18 December 2007MaintBotfixed category names
7431view12:42, 4 November 2007MaintBotAdded categories to GPML
19515view22:18, 22 May 2007J.S.Fonggpml file for [[Human:Monoamine_GPCRs]]
6353view22:18, 22 May 2007Nsalomonisgpml file for [[Human:Monoamine_GPCRs]]

External references


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NameTypeDatabase referenceComment
ADRA1AGeneProduct148 (Entrez Gene)
ADRA1BGeneProduct147 (Entrez Gene)
ADRA1DGeneProduct146 (Entrez Gene)
ADRA2AGeneProduct150 (Entrez Gene)
ADRA2BGeneProduct151 (Entrez Gene)
ADRA2CGeneProduct152 (Entrez Gene)
ADRB1GeneProduct153 (Entrez Gene)
ADRB2GeneProduct154 (Entrez Gene)
ADRB3GeneProduct155 (Entrez Gene)
Acetylcholine MetaboliteHMDB0000895 (HMDB)
CHRM1GeneProduct1128 (Entrez Gene)
CHRM2GeneProduct1129 (Entrez Gene)
CHRM3GeneProduct1131 (Entrez Gene)
CHRM4GeneProduct1132 (Entrez Gene)
CHRM5GeneProduct1133 (Entrez Gene)
DRD1GeneProduct1812 (Entrez Gene)
DRD2GeneProduct1813 (Entrez Gene)
DRD3GeneProduct1814 (Entrez Gene)
DRD4GeneProduct1815 (Entrez Gene)
DRD5GeneProduct1816 (Entrez Gene)
DopamineMetabolite62-31-7 (CAS)
EpinephrineMetaboliteHMDB0000068 (HMDB)
Gi/Go PathwayPathwayWP35 (WikiPathways)
Gq/G11 PathwayPathwayWP35 (WikiPathways)
Gs PathwayPathwayWP35 (WikiPathways)
HRH1GeneProduct3269 (Entrez Gene)
HRH2GeneProduct3274 (Entrez Gene)
HTR1AGeneProduct3350 (Entrez Gene)
HTR1BGeneProduct3351 (Entrez Gene)
HTR1DGeneProduct3352 (Entrez Gene)
HTR1EGeneProduct3354 (Entrez Gene)
HTR1FGeneProduct3355 (Entrez Gene)
HTR2AGeneProduct3356 (Entrez Gene)
HTR2BGeneProduct3357 (Entrez Gene)
HTR2CGeneProduct3358 (Entrez Gene)
HTR4GeneProduct3360 (Entrez Gene)
HTR5AGeneProduct3361 (Entrez Gene)
HTR5BGeneProduct645694 (Entrez Gene)
HTR6GeneProduct3362 (Entrez Gene)
HTR7GeneProduct3363 (Entrez Gene)
HistamineMetabolite51-45-6 (CAS)
MuscarineMetaboliteCHEBI:7034 (ChEBI)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
SerotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions

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