IL-2 Signaling Pathway (Rattus norvegicus)

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Molecule in the pathwayDesumoylationERDDDDDMethylationMitochondrionPhosphorylationCYReactions through unknown mechanisms/moleculesCY -> NUInhibitionCY -> NUMTMolecular associationDeacetylationPhosphorylationCytoplasmCY -> NUExtracellularNucleusPalmitolyationPMDeubiquitinationActivationControlGene SymbolRecruitmentSumoylationNUCY -> NUGlycosylationCY -> NUReceptorCY -> NUCY -> NUMTEndoplasmic reticulumENDDCY -> NUDemethylationDProteins in a complex interactionPlasma membraneDDUbiquitinationDProteolytic cleavageNucleus(Protein-protein interaction)EndosomeTranslocationDephosphorylationGolgi apparatusECCY -> PMPM -> CYAccession Number: NetPath 14DLigandNUAutophosphorylationEnzyme complexAcetylationGOCrkMapk3Grb2Ets1Sos1Raf1CishMapk8Socs1Il2Akt1Ybx1Il2raGnb2l1Pik3r2Stat5bMap2k1TertRelaIL2RBIcam1PrkczRaf1Jak1Hsp90aa1Akt1Nfkb1Bcl2FynPtpn6TertStam2Ybx1Gab2Irs1Socs3Irs2Stat5aMtorLynMknk1Jak3Mapk1Mapk9Il2Jak2Shc1PIK3CAIl2CrklKrasEts2Akt1Rps6kb1NmiPik3cbIFNA1Nfkb1Il2Ptk2bIl2Eif4eMap2k2StamSHBStat1Cd53Eif3s9Itm2bSykFoxo3Il2rgCreb1Mapk1Mapk3Pik3r1Vav1Nr3c1CrkPik3cdMapkapk2CblStat3Stat5aStat5bRelaPtpn11Plcb1LckChukPik3cgMapk14


IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at NetSlim database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, you must cite the NetPath website until the pathway is published.


This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 95% conversion rate.

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View all...
89844view12:15, 6 October 2016MkutmonRemove GenMAPP notes
89843view12:15, 6 October 2016MkutmonModified description
77327view17:43, 19 August 2014Mkutmonupdated schema
67370view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
41720view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
35781view06:19, 13 February 2010MaintBotAdded description
34097view19:18, 9 December 2009MaintBotAutomatic update of empty xrefs
31477view21:22, 13 August 2009MaintBotFixed text labels
30922view00:34, 30 July 2009MaintBotConverted from Homo sapiens
21878view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:IL-2 NetPath 14]] moved to [[Pathway:WP569]]: Moved to stable identifier
8168view13:46, 7 January 2008MaintBot[[Pathway:Rat:IL-2 NetPath 14]] moved to [[Pathway:Rattus norvegicus:IL-2 NetPath 14]]: Renaming species
7704view16:11, 18 December 2007MaintBotfixed category names
7243view12:41, 4 November 2007MaintBotAdded categories to GPML
6559view22:20, 22 May 2007A.Pandeygpml file for [[Rat:IL-2_NetPath_14]]

External references


View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
Bcl2GeneProduct24224 (Entrez Gene)
CblGeneProduct500985 (Entrez Gene)
Cd53GeneProduct24251 (Entrez Gene)
ChukGeneProduct309361 (Entrez Gene)
CishGeneProduct83681 (Entrez Gene)
Creb1GeneProduct81646 (Entrez Gene)
CrkGeneProduct54245 (Entrez Gene)
CrklGeneProduct287942 (Entrez Gene)
Eif3s9GeneProduct288516 (Entrez Gene)
Eif4eGeneProduct117045 (Entrez Gene)
Ets1GeneProduct24356 (Entrez Gene)
Ets2GeneProduct304063 (Entrez Gene)
Foxo3GeneProduct294515 (Entrez Gene)
FynGeneProduct25150 (Entrez Gene)
Gab2GeneProduct84477 (Entrez Gene)
Gnb2l1GeneProduct83427 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Hsp90aa1GeneProduct299331 (Entrez Gene)
IFNA1GeneProduct298210 (Entrez Gene)
IL2RBGeneProduct25746 (Entrez Gene)
Icam1GeneProduct25464 (Entrez Gene)
Il2GeneProduct116562 (Entrez Gene)
Il2raGeneProduct25704 (Entrez Gene)
Il2rgGeneProduct140924 (Entrez Gene)
Irs1GeneProduct25467 (Entrez Gene)
Irs2GeneProduct29376 (Entrez Gene)
Itm2bGeneProduct290364 (Entrez Gene)
Jak1GeneProduct84598 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
Jak3GeneProduct25326 (Entrez Gene)
KrasGeneProduct24525 (Entrez Gene)
LckGeneProduct313050 (Entrez Gene)
LynGeneProduct81515 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
Mapkapk2GeneProduct289014 (Entrez Gene)
Mknk1GeneProduct500526 (Entrez Gene)
MtorGeneProduct56718 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
NmiGeneProduct311021 (Entrez Gene)
Nr3c1GeneProduct24413 (Entrez Gene)
PIK3CAGeneProduct170911 (Entrez Gene)
Pik3cbGeneProduct85243 (Entrez Gene)
Pik3cdGeneProduct366508 (Entrez Gene)
Pik3cgGeneProduct298947 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct29741 (Entrez Gene)
Plcb1GeneProduct24654 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
Ptk2bGeneProduct50646 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
Ptpn6GeneProduct116689 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
RelaGeneProduct309165 (Entrez Gene)
Rps6kb1GeneProduct83840 (Entrez Gene)
Shc1GeneProduct85385 (Entrez Gene)
Socs1GeneProduct252971 (Entrez Gene)
Socs3GeneProduct89829 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
Stam2GeneProduct311030 (Entrez Gene)
StamGeneProduct498798 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)
SykGeneProduct25155 (Entrez Gene)
TertGeneProduct301965 (Entrez Gene)
Vav1GeneProduct25156 (Entrez Gene)
Ybx1GeneProduct500538 (Entrez Gene)

Annotated Interactions

No annotated interactions
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