Wnt Signaling Pathway (Rattus norvegicus)

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1PPhosphorylatedRecruitment to UnknownTranscriptional ActivationNucleusCytoskeletonFrizzled LigandsApoptosisUbiquitin TaggedB - CateninUbiquitin Conjugating EnzymeB26S Proteasome Degredation-CateninDVL2LdlrCcnd3Axin1Wnt2bFzd1Dvl1Wnt16Rac1PrkcqCcnd1FZD3Wnt3Wnt3aWnt2Pafah1b1PrkcgWnt10aWnt5aWnt1PrkcdRhoaWnt7aGsk3bMycFosl1JunWnt4Mapk9Fzd9TCF-1/LEFWnt10bWnt11Csnk1ePpp2r5eFzd5PrkcaMapk10PrkchPrkd1Dvl3Ctnnb1PrkczPpp2r5cFzd6Wnt5bPlauWnt16Fzd2FRAT1PrkciFZD7Fbxw2FZD10PrkcePrkcbWnt6Wnt7bApcFzd8Ccnd2Sfrp4


Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.


This pathway was inferred from Homo sapiens pathway WP428(r28695) with a 90% conversion rate.

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Ontology Terms



  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC Scholia


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109397view16:16, 16 March 2020L DupuisFixed interactions
71784view20:32, 17 October 2013MaintBotAutomated update of data sources
69376view18:56, 8 July 2013MaintBotUpdated to 2013 gpml schema
67752view11:58, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
41690view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
35125view13:35, 11 February 2010Thomasconnected line
35116view13:22, 11 February 2010Thomasadded literature
35107view13:15, 11 February 2010ThomasModified description
34076view19:11, 9 December 2009MaintBotAutomatic update of empty xrefs
32466view17:28, 15 August 2009MaintBotFixed text labels
32152view14:02, 14 August 2009MaintBotFixed group labels
31476view21:22, 13 August 2009MaintBotFixed text labels
30963view00:47, 30 July 2009MaintBotConverted from Homo sapiens
21868view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Wnt Signaling]] moved to [[Pathway:WP564]]: Moved to stable identifier
8492view13:46, 7 January 2008MaintBot[[Pathway:Rat:Wnt Signaling]] moved to [[Pathway:Rattus norvegicus:Wnt Signaling]]: Renaming species
7862view16:24, 18 December 2007MaintBotfixed category names
7317view12:42, 4 November 2007MaintBotAdded categories to GPML
19555view22:20, 22 May 2007M.Ramirezgpml file for [[Rat:Wnt_Signaling]]
6610view22:20, 22 May 2007M.Liebermangpml file for [[Rat:Wnt_Signaling]]

External references


View all...
NameTypeDatabase referenceComment
ApcGeneProduct24205 (Entrez Gene)
Axin1GeneProduct79257 (Entrez Gene)
Ccnd1GeneProduct58919 (Entrez Gene)
Ccnd2GeneProduct64033 (Entrez Gene)
Ccnd3GeneProduct25193 (Entrez Gene)
Csnk1eGeneProduct58822 (Entrez Gene)
Ctnnb1GeneProduct84353 (Entrez Gene)
DVL2GeneProduct303251 (Entrez Gene)
Dvl1GeneProduct83721 (Entrez Gene)
Dvl3GeneProduct303811 (Entrez Gene)
FZD3GeneProduct266715 (Entrez Gene)
FZD7GeneProduct301440 (Entrez Gene)
Fbxw2GeneProduct311881 (Entrez Gene)
Fosl1GeneProduct25445 (Entrez Gene)
Fzd1GeneProduct58868 (Entrez Gene)
Fzd2GeneProduct64512 (Entrez Gene)
Fzd5GeneProduct317674 (Entrez Gene)
Fzd6GeneProduct282581 (Entrez Gene)
Fzd8GeneProduct364754 (Entrez Gene)
Fzd9GeneProduct266608 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene) MOUSE:KG38 MOUSE
JunGeneProduct24516 (Entrez Gene)
LdlrGeneProduct300438 (Entrez Gene)
Mapk10GeneProduct25272 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
MycGeneProduct24577 (Entrez Gene)
Pafah1b1GeneProduct83572 (Entrez Gene)
PlauGeneProduct25619 (Entrez Gene)
Ppp2r5cGeneProduct691318 (Entrez Gene)
Ppp2r5eGeneProduct299147 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
PrkcdGeneProduct170538 (Entrez Gene)
PrkceGeneProduct29340 (Entrez Gene)
PrkcgGeneProduct24681 (Entrez Gene)
PrkchGeneProduct81749 (Entrez Gene)
PrkciGeneProduct84006 (Entrez Gene)
PrkcqGeneProduct85420 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
Prkd1GeneProduct85421 (Entrez Gene)
Rac1GeneProduct363875 (Entrez Gene)
RhoaGeneProduct117273 (Entrez Gene)
Sfrp4GeneProduct89803 (Entrez Gene)
Wnt10aGeneProduct316527 (Entrez Gene)
Wnt10bGeneProduct315294 (Entrez Gene)
Wnt11GeneProduct140584 (Entrez Gene)
Wnt1GeneProduct24881 (Entrez Gene)
Wnt16GeneProduct500047 (Entrez Gene)
Wnt2GeneProduct114487 (Entrez Gene)
Wnt2bGeneProduct116466 (Entrez Gene)
Wnt3GeneProduct24882 (Entrez Gene)
Wnt3aGeneProduct303181 (Entrez Gene)
Wnt4GeneProduct84426 (Entrez Gene)
Wnt5aGeneProduct64566 (Entrez Gene)
Wnt5bGeneProduct282582 (Entrez Gene)
Wnt6GeneProduct316526 (Entrez Gene)
Wnt7aGeneProduct114850 (Entrez Gene)
Wnt7bGeneProduct315196 (Entrez Gene)

Annotated Interactions

No annotated interactions
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