ACE Inhibitor Pathway (Rattus norvegicus)

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1Cell MembraneAgtr2AgtACE InhibitorAgtr1BradykininNos3AceAngiotensin IAngiotensin IIBdkrb2AceRen1Kng1Aldosterone


The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (

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  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC


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107000view13:45, 17 September 2019MaintBotHMDB identifier normalization
81317view19:16, 18 August 2015MaintBotremoved fill color for arc
70957view22:09, 17 September 2013MaintBotadded aldosterone xref
67021view09:55, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
63280view13:38, 9 May 2013EgonwForgot to set the database :(
63279view13:35, 9 May 2013EgonwAdded the ChEBI identifier for angiotensin-converting enzyme inhibitors
48278view23:28, 17 May 2012KhanspersUpdating PubChem xrefs
41786view02:43, 2 March 2011MaintBotRemoved redundant pathway information and comments
35051view09:46, 11 February 2010Thomasannotated metabolites, connected lines, added literature
35044view09:35, 11 February 2010Thomasremoved genmapp notes (invalid link)
35036view09:28, 11 February 2010ThomasModified description
21852view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:WP557]]: Moved to stable identifier
11889view18:22, 8 May 2008KhanspersChanged contact info
7876view13:46, 7 January 2008MaintBot[[Pathway:Rat:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:Rattus norvegicus:ACE-Inhibitor pathway PharmGKB]]: Renaming species
7563view16:00, 18 December 2007MaintBotfixed category names
7451view12:42, 4 November 2007MaintBotAdded categories to GPML
6513view22:19, 22 May 2007C.F.Thorngpml file for [[Rat:ACE-Inhibitor_pathway_PharmGKB]]

External references


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NameTypeDatabase referenceComment
ACE InhibitorMetaboliteCHEBI:35457 (ChEBI)
AceGeneProduct24310 (Entrez Gene)
AgtGeneProduct24179 (Entrez Gene)
Agtr1GeneProduct81638 (Entrez Gene)
Agtr2GeneProduct24182 (Entrez Gene)
AldosteroneMetaboliteCHEBI:27584 (ChEBI)
Angiotensin IMetabolite3081372 (PubChem-compound)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
Bdkrb2GeneProduct25245 (Entrez Gene)
BradykininMetaboliteHMDB0004246 (HMDB)
Kng1GeneProduct24903 (Entrez Gene)
Nos3GeneProduct24600 (Entrez Gene)
Ren1GeneProduct24715 (Entrez Gene)

Annotated Interactions

No annotated interactions

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