Complement and Coagulation Cascades (Rattus norvegicus)

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Kinin kallikrein systemClassical PathwayPlatelet, monocyte,lymphocyte,endothelial cells,smooth muscle cellsactivation etc.Lectin Pathwayfibrin degredationproductsFibrinolytic systemC3ConvertaseC5aClotVascular injuryFibrinmonomerAntibody/antigencomplexMuscle contraction,Chemotaxis,Phagocyte recruitment,Inflammation, etc.C3b/BbZymosaninsulin, etc.membrane attack complexC4b/2aCell lysisCoagulation CascadeCross-linkedExtrinsic pathwayMediatorsCell adhesion,migration,proliferation, etc.fibrin polymerComplement CascadeC3b/4b, C3b, C3dDegredationC3bCollagen,basement membrane,activated platelets, etc.C3aAlternative PathwayC4aCell adhesion,migration,proliferation, etc.Serpinc1TfpiPlaurF11RGD:727845PlatA2mC7CfiFgbCfhMasp1F10C1sDaf1C5r1HcCrryPlgH2-BfDaf2Serpind1C1qbCr2Masp2Serpinf2ThbdProcF7Serpina1C6C1qgF2rSerpine1C2C3ar1F13bSerpina5F12BradykininF9F5C9RGD:621759C3AdnC1qaPlauC4bpRGD:735225CrryC4aC8bKlkb1C1rCd59Kng1F3F2McpMbl1Pros1Cpb2Bdkrb1


The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Source: KEGG

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106999view13:45, 17 September 2019MaintBotHMDB identifier normalization
91912view21:08, 3 April 2017KhanspersModified description
91911view21:07, 3 April 2017Khanspersremoved GenMAPP comments
83032view02:42, 18 November 2015Mkutmonfix outdated identifier
79832view09:22, 17 April 2015EgonwReplaced a gene name with its Entrez Gene identifier.
79658view17:51, 1 April 2015Khanspersreplacing non-numeric Entrez
69384view18:57, 8 July 2013MaintBotUpdated to 2013 gpml schema
67785view15:14, 26 June 2013DdiglesOntology Term : 'complement system pathway' added !
67125view10:09, 26 June 2013Christine ChichesterOntology Term : 'coagulation cascade pathway' added !
41700view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
38702view19:27, 23 September 2010AlexanderPico
34319view22:12, 9 December 2009KhanspersAdded connectors
34313view22:09, 9 December 2009KhanspersPeriodical save, work in progress
34283view21:59, 9 December 2009KhanspersPeriodical save, work in progress
34254view21:48, 9 December 2009KhanspersPeriodical save, work in progress
34230view21:37, 9 December 2009KhanspersPeriodical save, work in progress
22596view13:44, 14 November 2008ThomasChanged pathway title (was duplicate of WP81)
21830view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Complement and Coagulation Cascades KEGG]] moved to [[Pathway:WP547]]: Moved to stable identifier
7976view13:46, 7 January 2008MaintBot[[Pathway:Rat:Complement and Coagulation Cascades KEGG]] moved to [[Pathway:Rattus norvegicus:Complement and Coagulation Cascades KEGG]]: Renaming species
7612view16:04, 18 December 2007MaintBotfixed category names
7469view12:42, 4 November 2007MaintBotAdded categories to GPML
6528view22:19, 22 May 2007169.230.77.174gpml file for [[Rat:Complement_and_Coagulation_Cascades_KEGG]]

External references


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NameTypeDatabase referenceComment
A2mGeneProduct24153 (Entrez Gene)
AdnGeneProduct54249 (Entrez Gene)
Bdkrb1GeneProduct81509 (Entrez Gene)
BradykininMetaboliteHMDB0004246 (HMDB)
C1qaGeneProduct298566 (Entrez Gene)
C1qbGeneProduct29687 (Entrez Gene)
C1qgGeneProduct362634 (Entrez Gene)
C1rGeneProduct312705 (Entrez Gene)
C1sGeneProduct192262 (Entrez Gene)
C2GeneProduct24231 (Entrez Gene)
C3GeneProduct24232 (Entrez Gene)
C3ar1GeneProduct84007 (Entrez Gene)
C4aGeneProduct24233 (Entrez Gene)
C4bpGeneProduct24234 (Entrez Gene)
C5r1GeneProduct113959 (Entrez Gene)
C6GeneProduct24237 (Entrez Gene)
C7GeneProduct117517 (Entrez Gene)
C8bGeneProduct313421 (Entrez Gene)
C9GeneProduct117512 (Entrez Gene)
Cd59GeneProduct25407 (Entrez Gene)
CfhGeneProduct155012 (Entrez Gene)
CfiGeneProduct79126 (Entrez Gene)
Cpb2GeneProduct113936 (Entrez Gene)
Cr2GeneProduct289395 (Entrez Gene)
CrryGeneProduct54243 (Entrez Gene)
Daf1GeneProduct64036 (Entrez Gene)
F10GeneProduct29243 (Entrez Gene)
F11GeneProduct290757 (Entrez Gene)
F12GeneProduct306761 (Entrez Gene)
F13bGeneProduct289055 (Entrez Gene)
F2GeneProduct29251 (Entrez Gene)
F2rGeneProduct25439 (Entrez Gene)
F3GeneProduct25584 (Entrez Gene)
F5GeneProductENSRNOG00000057855 (Ensembl)
F7GeneProduct260320 (Entrez Gene)
F9GeneProduct24946 (Entrez Gene)
FgbGeneProduct24366 (Entrez Gene)
H2-BfGeneProduct294257 (Entrez Gene)
HcGeneProduct24441 (Entrez Gene)
Klkb1GeneProduct25048 (Entrez Gene)
Kng1GeneProduct24903 (Entrez Gene)
Masp1GeneProduct64023 (Entrez Gene)
Masp2GeneProduct64459 (Entrez Gene)
Mbl1GeneProduct24548 (Entrez Gene)
McpGeneProduct29333 (Entrez Gene)
PlatGeneProduct25692 (Entrez Gene)
PlauGeneProduct25619 (Entrez Gene)
PlaurGeneProduct50692 (Entrez Gene)
PlgGeneProduct85253 (Entrez Gene)
ProcGeneProduct25268 (Entrez Gene)
Pros1GeneProduct81750 (Entrez Gene)
RGD:621759GeneProduct116669 (Entrez Gene)
RGD:727845GeneProduct302470 (Entrez Gene)
RGD:735225GeneProduct295703 (Entrez Gene)
Serpina1GeneProduct24648 (Entrez Gene)
Serpina5GeneProduct65051 (Entrez Gene)
Serpinc1GeneProduct304917 (Entrez Gene)
Serpind1GeneProduct79224 (Entrez Gene)
Serpine1GeneProduct24617 (Entrez Gene)
Serpinf2GeneProduct287527 (Entrez Gene)
TfpiGeneProduct29436 (Entrez Gene)
ThbdGeneProduct83580 (Entrez Gene)

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