Wnt Signaling Pathway NetPath (Mus musculus)

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CY->NUMethylationRecruitmentNU->CYPhosphorylationSumoylationDesumoylationActivationEnzyme ComplexGOComplex formationDCytoplasmAcetylationExtracellularMolecule in the pathwayDEndosomePlasma membraneENReceptorReaction through unknowm mechanisms/moleculesMitochondrionGlycosylationMolecular AssociationEndoplasmic reticulumDGolgi apparatusDeacetylationDPMProteins in a complex interactionNucleusCY->NUCYDephosphorylationDECControlInhibitionCY->PMUbiquitination(Protein-protein interaction)CY->PMDCY->PMCY->NUCY->PMPalmitoylationAutophosphorylationDemethylationDLigandNUAccession Number: NetPath 8; cellmap:8ERDeubiquitinationMTCY->NUPM->CYTranslocationCY->NUDDGene SymbolProteolytic 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


Description

Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone.

Source: NethPath

Additional comments:

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
71716view20:15, 17 October 2013MaintBotAutomated update of data sources
69059view18:07, 8 July 2013MaintBotUpdated to 2013 gpml schema
67761view12:00, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
41242view00:19, 2 March 2011MaintBotRemoved redundant pathway information and comments
35027view09:16, 11 February 2010Thomasremoved old genmapp comments (moved to description)
35019view09:09, 11 February 2010ThomasModified description
34371view22:42, 9 December 2009MaintBotAutomatic update of empty xrefs
22587view13:38, 14 November 2008ThomasChanged pathway title (was duplicate of WP403)
21814view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Wnt NetPath 8]] moved to [[Pathway:WP539]]: Moved to stable identifier
8484view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Wnt NetPath 8]] moved to [[Pathway:Mus musculus:Wnt NetPath 8]]: Renaming species
7858view16:23, 18 December 2007MaintBotfixed category names
7314view12:42, 4 November 2007MaintBotAdded categories to GPML
6509view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:Wnt_NetPath_8]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct11651 (Entrez Gene)
Ankrd6GeneProduct140577 (Entrez Gene)
ApcGeneProduct11789 (Entrez Gene)
Arrb1GeneProduct109689 (Entrez Gene)
Arrb2GeneProduct216869 (Entrez Gene)
Axin1GeneProduct12005 (Entrez Gene)
Axin2GeneProduct12006 (Entrez Gene)
Bcl9GeneProduct77578 (Entrez Gene)
Brd7GeneProduct26992 (Entrez Gene)
BtrcGeneProduct12234 (Entrez Gene)
Camk2aGeneProduct12322 (Entrez Gene)
Camk2bGeneProduct12323 (Entrez Gene)
Camk2dGeneProduct108058 (Entrez Gene)
Camk2gGeneProduct12325 (Entrez Gene)
Ccnd1GeneProduct12443 (Entrez Gene)
Cdc25cGeneProduct12532 (Entrez Gene)
Cdc2aGeneProduct12534 (Entrez Gene)
Cdh1GeneProduct12550 (Entrez Gene)
Crybb2GeneProduct12961 (Entrez Gene)
Csnk1a1GeneProduct93687 (Entrez Gene)
Csnk1dGeneProduct104318 (Entrez Gene)
Csnk1eGeneProduct27373 (Entrez Gene)
Csnk2a1GeneProduct12995 (Entrez Gene)
Csnk2a2GeneProduct13000 (Entrez Gene)
Csnk2bGeneProduct13001 (Entrez Gene)
Ctbp1GeneProduct13016 (Entrez Gene)
Ctbp2GeneProduct13017 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
Ctnnbip1GeneProduct67087 (Entrez Gene)
Cul1GeneProduct26965 (Entrez Gene)
Cxxc4GeneProduct319478 (Entrez Gene)
Daam1GeneProduct208846 (Entrez Gene)
Dab2GeneProduct13132 (Entrez Gene)
Dkk1GeneProduct13380 (Entrez Gene)
Dlgh1GeneProduct13383 (Entrez Gene)
Dlgh2GeneProduct23859 (Entrez Gene)
Dlgh4GeneProduct13385 (Entrez Gene)
Dvl1GeneProduct13542 (Entrez Gene)
Dvl2GeneProduct13543 (Entrez Gene)
Dvl3GeneProduct13544 (Entrez Gene)
Ep300GeneProduct328572 (Entrez Gene)
Fhl2GeneProduct14200 (Entrez Gene)
Frat1GeneProduct14296 (Entrez Gene)
Frat2GeneProduct212398 (Entrez Gene)
Fzd1GeneProduct14362 (Entrez Gene)
Fzd2GeneProduct57265 (Entrez Gene)
Fzd4GeneProduct14366 (Entrez Gene)
Fzd5GeneProduct14367 (Entrez Gene)
Fzd6GeneProduct14368 (Entrez Gene)
Fzd7GeneProduct14369 (Entrez Gene)
Fzd8GeneProduct14370 (Entrez Gene)
Fzd9GeneProduct14371 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
HIPK2GeneProduct15258 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
JupGeneProduct16480 (Entrez Gene)
LOC665283GeneProduct665283 (Entrez Gene)
Lef1GeneProduct16842 (Entrez Gene)
Lrp1GeneProduct16971 (Entrez Gene)
Lrp5GeneProduct16973 (Entrez Gene)
Lrp6GeneProduct16974 (Entrez Gene)
LtapGeneProduct93840 (Entrez Gene)
Magi3GeneProduct99470 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Mapk8ip1GeneProduct19099 (Entrez Gene)
Mapk9GeneProduct26420 (Entrez Gene)
Mark2GeneProduct13728 (Entrez Gene)
Mtap1bGeneProduct17755 (Entrez Gene)
MybGeneProduct17863 (Entrez Gene)
Nkd1GeneProduct93960 (Entrez Gene)
NlkGeneProduct18099 (Entrez Gene)
Nr5a1GeneProduct26423 (Entrez Gene)
PRKCGGeneProduct
Pax2GeneProduct18504 (Entrez Gene)
Pias4GeneProduct59004 (Entrez Gene)
Pin1GeneProduct23988 (Entrez Gene)
Ppp2caGeneProduct19052 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
Prkcb1GeneProduct18751 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Ror2GeneProduct26564 (Entrez Gene)
Runx2GeneProduct12393 (Entrez Gene)
Ruvbl1GeneProduct56505 (Entrez Gene)
Sall1GeneProduct58198 (Entrez Gene)
Senp2GeneProduct75826 (Entrez Gene)
Sfrp1GeneProduct20377 (Entrez Gene)
Sfrp2GeneProduct20319 (Entrez Gene)
Skp1aGeneProduct21402 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
Smad4GeneProduct17128 (Entrez Gene)
Sox1GeneProduct20664 (Entrez Gene)
Sox9GeneProduct20682 (Entrez Gene)
Sumo1GeneProduct22218 (Entrez Gene)
Tax1bp3GeneProduct76281 (Entrez Gene)
TbpGeneProduct21374 (Entrez Gene)
Tcf4GeneProduct21413 (Entrez Gene)
Tcfap2aGeneProduct21418 (Entrez Gene)
Tcfe2aGeneProduct21423 (Entrez Gene)
Wnt1GeneProduct22408 (Entrez Gene)
Wnt2GeneProduct22413 (Entrez Gene)
Wnt3GeneProduct22415 (Entrez Gene)
Wnt3aGeneProduct22416 (Entrez Gene)
Wnt4GeneProduct22417 (Entrez Gene)
Wnt5aGeneProduct22418 (Entrez Gene)
Wnt7aGeneProduct22421 (Entrez Gene)

Annotated Interactions

No annotated interactions

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