Lysine Biosynthesis (Saccharomyces cerevisiae)

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12-oxoglutaratesaccharopineL-2-aminoadipatealpha-ketoadipateH2ONAD2-oxoglutarateH2O2-oxoglutaratehomoaconitateNADPNADNADPhomocitrateaminoadipate-6-semialdehydeH2Ohomo-isocitrateH2OH2OH2OCO2NADPHL-lysineCoenzyme ALYS4L-glutamateNADHLYS2NADHLYS12LYS9LYS21LYS20L-glutamateLYS1NADPHLYS4acetyl-CoA


S. cerevisiae synthesizes the essential amino acid L-lysine via the L-alpha-aminoadipic acid pathway instead of the diaminopmelate pathway (CITS: [10714900]). Originally proposed to be characteristic of fungi, recent studies suggest prokaryotes also synthesize lysine via the alpha-aminoadipic acid pathway (CITS: [11029074]). Intermediates in this pathway are often incorporated into secondary metabolites. For example, it has been well- studied that alpha-aminoadipate is required for penicillin production (CITS: [10714900]). Regulation of the lysine biosynthetic pathway in S. cerevisiae is an interaction between general amino acid control (via Gcn4p) (CITS: [Hinnebusch]), feedback inhibition of homocitrate synthase activity by lysine (CITS: [10103047]), and induction of Lys14p by alpha-aminoadipate semialdehyde (CITS: [10975256]). SOURCE: SGD pathways,


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  1. Zabriskie TM, Jackson MD; ''Lysine biosynthesis and metabolism in fungi.''; Nat Prod Rep, 2000 PubMed Europe PMC


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89692view10:11, 26 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69940view20:14, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69660view20:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67437view11:01, 26 June 2013DdiglesOntology Term : 'lysine biosynthetic pathway' added !
41900view04:53, 2 March 2011MaintBotRemoved redundant pathway information and comments
36626view22:33, 9 April 2010MaintBotDescription and bibliography added from SGD
21800view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Lysine Biosynthesis]] moved to [[Pathway:WP533]]: Moved to stable identifier
12774view08:02, 17 May 2008MaintBotautomated metabolite conversion
8822view14:09, 7 January 2008MaintBotAdded to category $category
8820view14:09, 7 January 2008M.BraymerUploaded new pathway

External references


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NameTypeDatabase referenceComment
Coenzyme AMetabolite64885-97-8 (CAS)
L-glutamateMetabolite56-86-0 (CAS)
L-lysineMetabolite56-87-1 (CAS)
LYS12GeneProductS000001356 (SGD)
LYS1GeneProductS000001473 (SGD)
LYS20GeneProductS000002341 (SGD)
LYS21GeneProductS000002289 (SGD)
LYS2GeneProductS000000319 (SGD)
LYS4GeneProductS000002642 (SGD)
LYS9GeneProductS000005333 (SGD)
NADHMetabolite53-84-9 (CAS)
NADPHMetabolite53-57-6 (CAS)
acetyl-CoAMetabolite72-89-9 (CAS)

Annotated Interactions

No annotated interactions
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