TROP2 regulatory signaling (Homo sapiens)

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11TACSTD2351, 6151720, 4042112InHCT116cellsTROP2dimerTROP2 prevents IGF1 & MDKbinding to IGF1R &ALK, respectively, bycompetitive binding Up-regulationIntracellular(TROP2-ICD)In the leading edges of prostate cancer cells plated on FN In LNCaP cells and xenograftsleading toDNA condensationand decrease inhistone methylationInHUVECsProteinEnhanceddirectionalmigrationInMTE-4-14 cellsIn GBC-SD andSGC-996 cellsEnhancesGC cell tolerance tochemotherapy35, 37Ca2+CLDN1CLDN734PARP1CD56PSMAPSASOX2MYCTP63OCT3/4ARUpregulatedin VCaP cells &downregulatedin LNCaP cells& 22Rv1 cells SYPInLNCaPandPC-3cells 3434ABCC1NOTCH1In BGC-823 andHGC27 cells 2222222224CDKN2A2424Cell cycleregulationPRKAA224PIK3R1PAKT1T308S4732626, 28, 3928Proliferation and migrationof HN6, SCC4,MG63, KM12SMMNNG/HOS, U2OS,MTE4-14 andPC-9/GR cells10, 26, 28MMP241In 8505C,K1 andFT-133 cellsAP14112, 41MAPK8MAPK9Y185T183Y185T183MAPK1MAPK3Y187T185Y204T20213, 19, 21, 40, 414141PTENS380PDPK139393939IGF18, 118, 11MDK894, 9PRKCAPRKCD4CASP321In A549NSCLCs21MMP1321PECAM1EGFRY1173In A549NSCLCs21ACVRL1IGF1RY1604Y1151Y1150Y1135Y113688888, 19InHeLacells88RAC1GTP11ITGB1ITGA51, 6TLN1TLN1119, 40CREB1S133STAT1Y701RB1S780NFKB112SRCPTK2Y416Y397InPC3-2cellsJUNIn FT-133,FADU andMTE-4-14 cellsADAM10 25TACSTD2S32217CDH1Affinity:CLDN7>CLDN1BCL25, 18BAXInA2780,Hela and C33AcellsCTNNB17, 13FN1VIMCDH1Induces EMTin MGC803cells5, 13CDK4InHelaandC33Acells13In LNCaP &TRAMP C2 cells36CCND1CCNE1CDK2CDKN1BInPanc02, Hela and C33AcellsJAK2Y1008STAT3Y1007S727Y705141414In LN-229and U87-MGcellsPSEN2ADAM17 1515TACSTD2TROP2-ICD15PSEN1 ADAM17 153, 15In LNCaPcells 15153655Upregulatedin Panc02, Hela,C33ATRAMP C2 &HEP2 cells anddown-regulatedin MTE-4-14 cells34343434InLNCaP,PC-3,VCaP,DU-145cells34In LNCaP cells and xenografts,PC-3, andVCaP cells3434343434CTNNB171111In TROP2-overexpressingH1299,CL1-0and H23 lungcancer cells11In TROP2-overexpressingH1299,CL1-0and H23 lungcancer cells1111InH1299 andH23 cellsIGF2RIGF210101010RACK1121212391219, 403419CYNUCYNUFACEIn MTE-4-14 cells191919, 4021mRNAProteinmRNAProteinmRNA Down-regulationProtein Components of complex unknownCa2+ Calcium ionProteinProtein Proteins in complexProteinXXXX Proteins with/without phosphositeFACECYNUTROP2-ICD TROP2 intracellular domain Protein-protein interaction Kinase-substrate reaction Leads to through unknown mechanisms or indication of studied cell types Leads to decrease in activity or phosphorylation at sites Translocation of proteins Transcriptional or translational regulation of gene/protein expression Cytoplasm Cell leading edges Focal adhesions Nucleus Figure Legend TROP2 Regulatory signaling networkPAK4S4741115NUMBIn v-SRC PECcells 1539


Description

Schematic representation of TROP2 mediated signaling mechanism in different types of cancers

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Bibliography

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History

CompareRevisionActionTimeUserComment
124970view20:26, 10 January 2023KhanspersOntology Term : 'signaling pathway' added !
124847view21:13, 14 December 2022EweitzModified title
124560view00:44, 9 November 2022EweitzModified title
124536view08:11, 7 November 2022Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCC1Protein4363 (Entrez Gene)
ACVRL1Protein94 (Entrez Gene)
ADAM10 Protein102 (Entrez Gene)
ADAM17 Protein6868 (Entrez Gene)
AKT1Protein4070 (Entrez Gene)
AP1Protein4070 (Entrez Gene)
ARProtein9076 (Entrez Gene)
BAXProtein581 (Entrez Gene)
BCL2Protein596 (Entrez Gene)
CASP3Protein9076 (Entrez Gene)
CCND1Protein595 (Entrez Gene)
CCNE1Protein898 (Entrez Gene)
CD56Protein9076 (Entrez Gene)
CDH1Protein999 (Entrez Gene)
CDK2Protein1017 (Entrez Gene)
CDK4Protein1019 (Entrez Gene)
CDKN1BProtein1027 (Entrez Gene)
CDKN2AProtein1029 (Entrez Gene)
CLDN1Protein9076 (Entrez Gene)
CLDN7Protein1366 (Entrez Gene)
CREB1Protein3725 (Entrez Gene)
CTNNB1Protein1499 (Entrez Gene)
Ca2+Metabolite
EGFRProtein1956 (Entrez Gene)
FN1Protein2335 (Entrez Gene)
IGF1Protein3479 (Entrez Gene)
IGF1RProtein3480 (Entrez Gene)
IGF2Protein3481 (Entrez Gene)
IGF2RProtein3482 (Entrez Gene)
ITGA5Protein3678 (Entrez Gene)
ITGB1Protein3688 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
MAPK1Protein9076 (Entrez Gene)
MAPK3Protein9076 (Entrez Gene)
MAPK8Protein9076 (Entrez Gene)
MAPK9Protein9076 (Entrez Gene)
MDKProtein4192 (Entrez Gene)
MMP13Protein4322 (Entrez Gene)
MMP2Protein1111 (Entrez Gene)
MYCProtein9076 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NOTCH1Protein4851 (Entrez Gene)
NUMBRna8650 (Entrez Gene)
OCT3/4Protein9076 (Entrez Gene)
PAK4Protein10298 (Entrez Gene)
PARP1Protein9076 (Entrez Gene)
PDPK1Protein4070 (Entrez Gene)
PECAM1Protein5175 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PRKAA2Protein4851 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PSAProtein9076 (Entrez Gene)
PSEN1 Protein5663 (Entrez Gene)
PSEN2Protein5664 (Entrez Gene)
PSMAProtein9076 (Entrez Gene)
PTENProtein5728 (Entrez Gene)
PTK2Protein5747 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RACK1Protein10399 (Entrez Gene)
RB1Protein5925 (Entrez Gene)
SOX2Protein9076 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein9076 (Entrez Gene)
SYPProtein9076 (Entrez Gene)
TACSTD2Protein4070 (Entrez Gene)
TLN1Protein7094 (Entrez Gene)
TP63Protein9076 (Entrez Gene)
VIMProtein7431 (Entrez Gene)

Annotated Interactions

No annotated interactions

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