Cytokines and Inflammatory Response (Homo sapiens)

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1Hypothalamus(fever)TcNeutrophilT-helperNK cellantigenantibodiesB CellThMHC IIB CellMast CellB CellEosClonal expansion of T cellsEosLymphocyte ActivatedKiller Cells (LAK)ThB CellMacrophageTcTcPlasma CellEndothelial CellsHematopoiesisEosTCR Hematopoietic Stem CellT-helperFibroblastsThIL5HLA-DRAIL15IL10IL12BTGFB1TRAIL10IL3IL10IL3IL1APDGFAIL4TNFIL10IL15IL4IL4IL3IL4IFN1@IL1BIL11IL12IL1ACSF2CXCL1IL2CXCL2IFNGTGFB1CD4IL2IL1AIL3IL2IL1BIL2IFN1@IL2IL1A Inflammatory ResponseTNFTNFTNFIL12BTNFIL1BIL5IL13TNFTRBIFNGIL6IL6IL6IFNB1IL1ACSF3IL7TNFCSF1TGFB1IL6IL1BIL6IL15IFNGCSF2IL13IL2IL2HLA-DRB1IL4IL1B


Inflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an important part of the immune response, but chronic inappropriate inflammation can lead to destruction of tissues in autoimmune disorders and perhaps neurodegenerative or cardiovascular disease. Secreted cytokine proteins provide signals between immune cells to coordinate the inflammatory response. Sources: BioCarta.


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  1. Kataoka T; ''Chemical biology of inflammatory cytokine signaling.''; J Antibiot (Tokyo), 2009 PubMed


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94907view23:45, 12 October 2017Khanspersconnected interactions
94763view15:53, 5 October 2017Ryanmillerconnected unconnected lines
79331view11:46, 21 March 2015EgonwOh, it contained more gene names as identifiers. Also fixed now.
79328view11:19, 21 March 2015EgonwReplaced a gene name with its Entrez Gene identifier.
63173view20:28, 8 May 2013MaintBotUpdating gpml version
53161view08:08, 30 October 2012Jack007Periodical save, work in progress
53160view07:51, 30 October 2012Jack007box enlarge
41163view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
40019view02:30, 26 January 2011AlexanderPicoModified description
39750view06:37, 17 January 2011AlexanderPico
38645view12:16, 23 September 2010FerryJagersLinked Inflammatory Response pathway
38185view22:54, 23 August 2010AlexanderPicoModified description
35247view19:54, 11 February 2010Thomasadded literature
32459view17:25, 15 August 2009MaintBotFixed text labels
32142view13:58, 14 August 2009MaintBotFixed group labels
21794view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cytokines and Inflammatory Response Biocarta]] moved to [[Pathway:WP530]]: Moved to stable identifier
15005view21:26, 24 May 2008AlexanderPicoGrouped, labeled and connected!
15002view21:24, 24 May 2008AlexanderPicoPeriodical save, work in progress
15000view21:14, 24 May 2008AlexanderPicoPeriodical save, work in progress
14998view21:04, 24 May 2008AlexanderPicoPeriodical save, work in progress
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14991view20:44, 24 May 2008AlexanderPicoPeriodical save, work in progress
14989view20:33, 24 May 2008AlexanderPicoPeriodical save, work in progress
14553view05:21, 23 May 2008AlexanderPicoModified description
12934view10:41, 17 May 2008MaintBotSticky edges patch by Sjoerd
7978view13:46, 7 January 2008MaintBot[[Pathway:Human:Cytokines and Inflammatory Response Biocarta]] moved to [[Pathway:Homo sapiens:Cytokines and Inflammatory Response Biocarta]]: Renaming species
7613view16:04, 18 December 2007MaintBotfixed category names
7470view12:42, 4 November 2007MaintBotAdded categories to GPML
6306view22:17, 22 May 2007S.Burelgpml file for [[Human:Cytokines_and_Inflammatory_Response_Biocarta]]

External references


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NameTypeDatabase referenceComment
Inflammatory ResponsePathwayWP453 (WikiPathways)
CD4GeneProduct920 (Entrez Gene)
CSF1GeneProduct1435 (Entrez Gene)
CSF2GeneProduct1437 (Entrez Gene)
CSF3GeneProduct1440 (Entrez Gene)
CXCL1GeneProduct2919 (Entrez Gene)
CXCL2GeneProduct2920 (Entrez Gene)
HLA-DRAGeneProduct3122 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
IFN1@GeneProduct3438 (Entrez Gene)
IFNB1GeneProduct3456 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IL10GeneProduct3586 (Entrez Gene)
IL11GeneProduct3589 (Entrez Gene)
IL12GeneProduct3593 (Entrez Gene)
IL12BGeneProduct3593 (Entrez Gene)
IL13GeneProduct3596 (Entrez Gene)
IL15GeneProduct3600 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL3GeneProduct16187 (Entrez Gene)
IL3GeneProduct3562 (Entrez Gene)
IL4GeneProduct3565 (Entrez Gene)
IL5GeneProduct3567 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL7GeneProduct3574 (Entrez Gene)
PDGFAGeneProduct5154 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TRAGeneProduct6955 (Entrez Gene)
TRBGeneProduct6957 (Entrez Gene)

Annotated Interactions

No annotated interactions
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