mRNA Processing (Rattus norvegicus)

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1PKinases Phosphorylating RS domains?AGSR-proteins5'U535splicing factor SF3AsnRNP Sm core complexpre-mRNA(2)U4Formation of pre-mRNPsSR-repressor proteinsPrimary RNA transcript3'3'65hnRNP regulatorsSR-proteinsCPSFexon 2AAGPutative Alternative SplicingRegulatorsFormation of the Spliceosomal B complexAGCleavage at the 3'-Splice-Site and Exon Ligationheterogeneous nuclear ribonucleoproteinsFormation of the Spliceosomal A complex3'Accessory Proteinsexon 1exon 13'ARngtt (capping enzyme)U4:U5:U6 tri-snRNP complex(2c)U2 snRNPYYYY5'CACap BindingCF II(2b)5'U5 snRNPFormation of the Spliceosomal A complexLariat Formation and 5'-Splice Site CleavageAAdditional Factorsintronsplicing factor SF3BYYYYRNAi pathwayYYYYCstFCleavage of mRNA at the 3'-endRegulation ofAlternative SplicingFormation of the Spliceosomal C complexGUYYYYPoly(A)-binding protein II(1)AGmRNA splice site selectionU4/U6mRNA Cappingexon 1Internal methylation of mRNASR-phosphatasesU1U1 snRNPAAAAAAACPSFSF3b14bmRNA polyadenylationsnRNP Sm core complexSR-binding sitesA5'RNA helicase A(2a)Methylation of mRNAexon 2Additional SR proteinsMisc.P-iPoAAUAAACF IdegradedU1 snRNPPoly(A) polymerase alphaU2AFAdditional FactorsU5exon 2Note: New participating members shown at each step3'mRNA 3'-end processingFormation of the Spliceosomal E complex5'Serine/Argenine Rich Proteins(SR)SR-binding sitesFormation of the Spliceosomal E complex(3)Poly(A)pb IIPolr2a3'exon 2CF IIYYYYU4 snRNPU6 snRNPSR-proteinsSR protein phosphatasesSR-kinasesSpt5AGmRNA splicing (major pathway)mRNA capping3'YYYYU2 snRNPright click on blue text for detailed informationRnmt (methyltransferase)U2 snRNPsexon 1splicesome associated helicasesAdditional FactorsU6snRNP Sm core complexAexon 1exon 2Formation of the Spliceosomal B complexU23'Processing of Intron-Containing Pre-mRNA5'CFI3'A5'U2AFInternal methylation of mRNA5' G cap3'CstF5'5'SR protein kinasesexon 2UGhnRNPsAGexon 15'RNA helicaseUG3'Formation of pre-mRNPsFormation of the active Spliceosomal C complexPi5'Poly(A) polU2af1Smc1aPtbp1U2af2Dhx9Prmt2Snrpd1RngttAC126899.1Sf3b1Srsf3Cd2bp2Prpf4Cdc40DNAJC8Mettl3Sf3b3U2Snrnp70Rbm5Nxf1Snu13Celf4Prpf4RnmtYbx1HnrnpmSrek1SfpqSrrm1Clk4Ddx1Prpf8U1 snRNACpsf1Ddx20ClasrpNudt21SnrpaPrpf8U5 snRNACstf1Lsm7Srpk1Ptbp2Prpf18SfswapXrn2Sf3b5AABR07051190.1Srsf1Sf3a1Pskh1Cpsf4Rbm17NonoSnrpfU4 snRNAHNRPCPapolaSf3a3Clk3Hnrnph1Sugp2Sf3b2Dhx8Eftud2Supt5hPrpf40aRnu6Sf3a2Ncbp1SNRPGSnrpnSrsf9Snrpa1Snu13Cstf2tSRPK2Srsf5LOC103689931HnrnpdSnrpep2Srsf2Celf1POLR2AHnrnpkPpm1gHnrnpuSNRPD2GMPPCBP2SpopClk1Rbm39Dhx15Snrnp40Dhx16Tmed10ATPPrpf6Celf2Snrpb2Sugp1Sf3b4Srsf4Cdc40HNRPA3P1AC126899.1Cstf3Srsf7Snrpd3Prmt1Clp1FusSrsf10RbmxNcbp2Snu13Cpsf3Cstf2SnrpbHnrnph2HnrnprSnrpnSrsf6Dicer1Clk2AABR07060628.1Hnrnpa2b1Txnl4aLOC688526Prpf4bSrp54aSrsf10Cpsf2Dhx38Tra2bPhf5aPrpf3Pabpn1


Description

This process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA).

The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' polyadenylation, and RNA splicing, which occur in the cell nucleus before the RNA is translated.

5' Capping: Capping of the pre-mRNA involves the addition of 7-methylguanosine (m7G) to the 5' end. The cap protects the 5' end of the primary RNA transcript from attack by ribonucleases that have specificity to the 3'5' phosphodiester bonds.

3' Processing: The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 200 adenine residues to form a poly(A) tail. As the poly(A) tails is synthesised, it binds multiple copies of poly(A) binding protein, which protects the 3'end from ribonuclease digestion.

Splicing: RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule.

Description adapted from Wikipedia: http://en.wikipedia.org/wiki/Post-transcriptional_modification

Pathway adapted from http://www.reactome.org.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP411 (r95128) with a 91.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Carmody SR, Wente SR; ''mRNA nuclear export at a glance.''; J Cell Sci, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95766view14:20, 19 January 2018MkutmonHomology conversion update
78477view10:28, 7 January 2015MaintBotadded missing graphIds
71768view20:30, 17 October 2013MaintBotAutomated update of data sources
69333view18:50, 8 July 2013MaintBotUpdated to 2013 gpml schema
67500view11:10, 26 June 2013DdiglesOntology Term : 'spliceosome pathway' added !
47776view05:42, 6 April 2012Khanspersupdated xref
41645view02:33, 2 March 2011MaintBotRemoved redundant pathway information and comments
35232view19:07, 11 February 2010KhanspersUpdated xrefs
35231view18:57, 11 February 2010KhanspersModified description
34047view19:01, 9 December 2009MaintBotAutomatic update of empty xrefs
32458view17:25, 15 August 2009MaintBotFixed text labels
32141view13:58, 14 August 2009MaintBotFixed group labels
31474view21:20, 13 August 2009MaintBotFixed text labels
30968view00:48, 30 July 2009MaintBotConverted from Homo sapiens
21792view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:mRNA processing Reactome]] moved to [[Pathway:WP529]]: Moved to stable identifier
8276view13:46, 7 January 2008MaintBot[[Pathway:Rat:mRNA processing Reactome]] moved to [[Pathway:Rattus norvegicus:mRNA processing Reactome]]: Renaming species
7758view16:16, 18 December 2007MaintBotfixed category names
7320view12:42, 4 November 2007MaintBotAdded categories to GPML
6611view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:mRNA_processing_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AABR07051190.1GeneProductENSRNOG00000005062 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3191
AABR07060628.1GeneProductENSRNOG00000051748 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3178
AC126899.1GeneProductENSRNOG00000011065 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:57819
ATPMetabolite1927-31-7 (CAS)
Cd2bp2GeneProductENSRNOG00000017201 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10421
Cdc40GeneProductENSRNOG00000000581 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51362
Celf1GeneProductENSRNOG00000010379 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10658
Celf2GeneProductENSRNOG00000023661 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10659
Celf4GeneProductENSRNOG00000014503 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:56853
ClasrpGeneProductENSRNOG00000046000 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11129
Clk1GeneProductENSRNOG00000025768 (Ensembl)
  • PMID: 15010457: Inhibitor John C. Bell, PhD

    Professor, Depts. of Medicine and Biochemistry, Microbiology & Immunology University of Ottawa Career Scientist, Ottawa Regional Cancer Centre Associate Scientist, The Ottawa Hospital Research Institute Telephone: 613-737-7700 ext 6893 Fax: 613-247-3524 Email: John.Bell@orcc.on.ca The control of pre-mRNA splicing by the Clk kinase family

    We are studying a family of kinases which we believe provide an interface between intracellular signaling networks and the post-transcriptional mechanism of mRNA splicing. We are performing a structure:function analysis of the three Clk family members to identify domains in the three proteins which are involved in regulating splicing. Using homologous recombination we are generating null strains of mice which are lacking one, two or all three Clk genes. The Clk kinases all possess dual specificity kinase activity and yeast expression systems are being used to produce large amounts of the kinase to perform a detailed analysis of the sites of serine, threonine and tyrosine autophosphorylation within the kinase.
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1195
Clk2GeneProductENSRNOG00000020500 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1196
Clk3GeneProductENSRNOG00000030126 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1198
Clk4GeneProductENSRNOG00000003714 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:57396
Clp1GeneProductENSRNOG00000007416 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10978
Cpsf1GeneProductENSRNOG00000030705 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:29894
Cpsf2GeneProductENSRNOG00000005733 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:53981
Cpsf3GeneProductENSRNOG00000052418 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51692
Cpsf4GeneProductENSRNOG00000000985 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10898
Cstf1GeneProductENSRNOG00000004775 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1477
Cstf2GeneProductENSRNOG00000048025 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1478
Cstf2tGeneProductENSRNOG00000050289 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23283
Cstf3GeneProductENSRNOG00000012089 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1479
DNAJC8GeneProductNo homologues found for original id L:22826
Ddx1GeneProductENSRNOG00000006652 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1653
Ddx20GeneProductENSRNOG00000015274 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11218
Dhx15GeneProductENSRNOG00000003844 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1665
Dhx16GeneProductENSRNOG00000030157 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8449
Dhx38GeneProductENSRNOG00000014619 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9785
Dhx8GeneProductENSRNOG00000020772 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1659
Dhx9GeneProductENSRNOG00000002735 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1660
Dicer1GeneProductENSRNOG00000010711 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23405
Eftud2GeneProductENSRNOG00000002818 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9343
FusGeneProductENSRNOG00000023360 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2521
GMPMetabolite85-32-5 (CAS)
HNRPA3P1GeneProduct
HNRPCGeneProductNo homologues found for original id L:3183
Hnrnpa2b1GeneProductENSRNOG00000011175 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3181
HnrnpdGeneProductENSRNOG00000002292 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3184
Hnrnph1GeneProductENSRNOG00000003399 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3187
Hnrnph2GeneProductENSRNOG00000011661 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3188
HnrnpkGeneProductENSRNOG00000019113 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3190
HnrnpmGeneProductENSRNOG00000007921 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4670
HnrnprGeneProductENSRNOG00000011910 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10236
HnrnpuGeneProductENSRNOG00000033790 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3192
LOC103689931GeneProductENSRNOG00000003645 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3182
LOC688526GeneProductENSRNOG00000027239 (Ensembl)
  • PMID: 14729963
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10921
Lsm7GeneProductENSRNOG00000019552 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51690
Mettl3GeneProductENSRNOG00000013111 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:56339
Ncbp1GeneProductENSRNOG00000023605 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4686
Ncbp2GeneProductENSRNOG00000001746 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:22916
NonoGeneProductENSRNOG00000003689 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4841
Nudt21GeneProductENSRNOG00000042983 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11051
Nxf1GeneProductENSRNOG00000019069 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10482
PCBP2GeneProductNo homologues found for original id L:5094
POLR2AGeneProductNo homologues found for original id L:5430
Pabpn1GeneProductENSRNOG00000042195 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8106
PapolaGeneProductENSRNOG00000004827 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10914
Phf5aGeneProductENSRNOG00000024170 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:84844
Ppm1gGeneProductENSRNOG00000026905 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5496
Prmt1GeneProductENSRNOG00000026109 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3276
Prmt2GeneProductENSRNOG00000001297 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3275
Prpf18GeneProductENSRNOG00000018396 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8559
Prpf3GeneProductENSRNOG00000025629 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9129
Prpf40aGeneProductENSRNOG00000004864 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:55660
Prpf4GeneProductENSRNOG00000014777 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9128
Prpf4bGeneProductENSRNOG00000016705 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8899
Prpf6GeneProductENSRNOG00000051498 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:24148
Prpf8GeneProductENSRNOG00000003495 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10594
Pskh1GeneProductENSRNOG00000019290 (Ensembl)
  • PMID: 12466556
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5681
Ptbp1GeneProductENSRNOG00000010448 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5725
Ptbp2GeneProductENSRNOG00000010827 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:58155
Rbm17GeneProductENSRNOG00000018767 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:84991
Rbm39GeneProductENSRNOG00000019848 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9584
Rbm5GeneProductENSRNOG00000018153 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10181
RbmxGeneProductENSRNOG00000000866 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:27316
RngttGeneProductENSRNOG00000007867 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8732
RnmtGeneProductENSRNOG00000016698 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8731
Rnu6RnaGenBank sequence: M10329
SNRPD2GeneProductNo homologues found for original id L:6633
SNRPGGeneProductNo homologues found for original id L:6637
SRPK2GeneProduct
  • PMID: 12773558
  • No homologues found for original id L:6733
Sf3a1GeneProductENSRNOG00000005218 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10291
Sf3a2GeneProductENSRNOG00000019349 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8175
Sf3a3GeneProductENSRNOG00000007629 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10946
Sf3b1GeneProductENSRNOG00000013516 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23451
Sf3b2GeneProductENSRNOG00000020412 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10992
Sf3b3GeneProductENSRNOG00000017724 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23450
Sf3b4GeneProductENSRNOG00000021181 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10262
Sf3b5GeneProductENSRNOG00000014908 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:83443
SfpqGeneProductENSRNOG00000058461 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6421
SfswapGeneProductENSRNOG00000000931 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6433
Smc1aGeneProductENSRNOG00000003139 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8243
Snrnp40GeneProductENSRNOG00000012219 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9410
Snrnp70GeneProductENSRNOG00000020763 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6625
Snrpa1GeneProductENSRNOG00000011932 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6627
SnrpaGeneProductENSRNOG00000001501 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6626
Snrpb2GeneProductENSRNOG00000004967 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6629
SnrpbGeneProductENSRNOG00000006961 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6628
Snrpd1GeneProductENSRNOG00000013714 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6632
Snrpd3GeneProductENSRNOG00000050410 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6634
Snrpep2GeneProductENSRNOG00000034206 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6635
SnrpfGeneProductENSRNOG00000005556 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6636
SnrpnGeneProductENSRNOG00000059764 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6638
Snu13GeneProductENSRNOG00000025154 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4809
SpopGeneProductENSRNOG00000004686 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8405
Srek1GeneProductENSRNOG00000032735 (Ensembl)
  • PMID: 14559993. SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and alternative splicing. These functions were most consistent with the model in which SRrp86 functions by interacting with and thereby modulating the activity of target proteins. To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry. We show that SRrp86 interacts with all of the core SR proteins, as well as a subset of other splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72. In contrast to previous results that showed activation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of SRrp86. Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection.
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:140890
Srp54aGeneProductENSRNOG00000032776 (Ensembl)
  • PMID: 14729963
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6729
Srpk1GeneProductENSRNOG00000000511 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6732
Srrm1GeneProductENSRNOG00000018194 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10250
Srsf10GeneProductENSRNOG00000007992 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10772
Srsf1GeneProductENSRNOG00000050323 (Ensembl)
  • Antagonist splicing factor
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6426
Srsf2GeneProductENSRNOG00000000248 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6427
Srsf3GeneProductENSRNOG00000000520 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6428
Srsf4GeneProductENSRNOG00000010007 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6429
Srsf5GeneProductENSRNOG00000005513 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6430
Srsf6GeneProductENSRNOG00000006380 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6431
Srsf7GeneProductENSRNOG00000027360 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6432
Srsf9GeneProductENSRNOG00000001163 (Ensembl)
  • PMID: 12738786, PMID: 12024014 (associated with hnRNP A1 splicing)
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8683
Sugp1GeneProductENSRNOG00000052111 (Ensembl)
  • inferred from: SURP 2, G patch protein, UniProt:O60378
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:57794
Sugp2GeneProductENSRNOG00000020269 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10147
Supt5hGeneProductENSRNOG00000032034 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6829
Tmed10GeneProductENSRNOG00000007901 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10972
Tra2bGeneProductENSRNOG00000001783 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6434
Txnl4aGeneProductENSRNOG00000052004 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10907
U1 snRNARnaGenBank sequence: J00645
U2GeneProductENSRNOG00000061106 (Ensembl)
  • GenBank sequence: K00027
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6066
U2af1GeneProductENSRNOG00000045860 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7307
U2af2GeneProductENSRNOG00000015914 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11338
U4 snRNARnaGenBank sequence: M10328, M18004
U5 snRNARnaGenBank sequence: AB021173
Xrn2GeneProductENSRNOG00000011785 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:22803
Ybx1GeneProductENSRNOG00000023786 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4904

Annotated Interactions

No annotated interactions
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