Cell interactions of the pancreatic cancer microenvironment (Homo sapiens)

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45213CD4+ T cellTreg cellTAMPancreatic cancer cellPancreatic stellate cellCD8+ T cellMDSCDendritic cellCSF1CCL5CSF2RACCR2CCR2CCR5KDRCXCL12BAG3CSF2CTLA4CD86VEGFACD80TRACXCR4FASIFITM2FASLGVEGFACXCR3CXCL10HLA-DRALAG3HLA-DRB1CCL2CSF1RCCL5NRP1avβ6TGFB16HLA-DRB1HLA-DRATRBTRATRBLAG36


Description

The molecular interactions of different cells in the pancreatic cancer tumor microenvironment (TME). Pancreatic cancer cells have developed various ways of evading and manipulating the immune system, and the TME plays an essential role in this. Various molecular interactions are involved in the interactions between cells in the TME.

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Ontology Terms

 

Bibliography

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  1. Costache MI, Ioana M, Iordache S, Ene D, Costache CA, Săftoiu A; ''VEGF Expression in Pancreatic Cancer and Other Malignancies: A Review of the Literature.''; Rom J Intern Med, 2015 PubMed Europe PMC Scholia
  2. Balachandran VP, Beatty GL, Dougan SK; ''Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities.''; Gastroenterology, 2019 PubMed Europe PMC Scholia
  3. Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC; ''BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.''; Nat Commun, 2015 PubMed Europe PMC Scholia
  4. Fan JQ, Wang MF, Chen HL, Shang D, Das JK, Song J; ''Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma.''; Mol Cancer, 2020 PubMed Europe PMC Scholia
  5. Matkar PN, Singh KK, Rudenko D, Kim YJ, Kuliszewski MA, Prud'homme GJ, Hedley DW, Leong-Poi H; ''Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma.''; Oncotarget, 2016 PubMed Europe PMC Scholia
  6. Andrews LP, Marciscano AE, Drake CG, Vignali DA; ''LAG3 (CD223) as a cancer immunotherapy target.''; Immunol Rev, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
124340view14:10, 17 October 2022IsabelWassinkModified description
124336view11:48, 17 October 2022IsabelWassinkNew data nodes and literature added
124325view09:00, 14 October 2022IsabelWassinkPathway extended
124299view13:33, 11 October 2022IsabelWassinkUpdated the T cell receptor data nodes
124261view09:54, 6 October 2022IsabelWassinkChanged genes to their official gene names and updated the visualisation of secreted factors
124257view14:01, 5 October 2022IsabelWassinkUpdated the MHC complex data nodes
124214view11:43, 30 September 2022IsabelWassinkData node annotations and literature reference added
124213view08:24, 30 September 2022IsabelWassinkUpdated data node annotation of VEGFA and added a reference
124200view14:46, 27 September 2022IsabelWassinkModified description
124196view08:20, 27 September 2022IsabelWassinkChanged layout and updated datanode annotations
124193view13:12, 26 September 2022Mkutmonchange FAS from metabolite to gene product
124192view13:09, 26 September 2022MkutmonModified title
124191view13:07, 26 September 2022MkutmonModified title
124190view13:07, 26 September 2022MkutmonModified title
124093view13:16, 19 September 2022IsabelWassinkModified title
124060view10:37, 15 September 2022IsabelWassinkOntology Term : 'pancreatic cancer pathway' added !
124059view10:37, 15 September 2022IsabelWassinkOntology Term : 'pancreatic cancer' added !
124058view10:35, 15 September 2022IsabelWassinkModified description
124057view10:32, 15 September 2022IsabelWassinkNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BAG3GeneProductENSG00000151929 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CCR2GeneProductENSG00000121807 (Ensembl)
CCR5GeneProductENSG00000160791 (Ensembl)
CD80GeneProductENSG00000121594 (Ensembl)
CD86GeneProductENSG00000114013 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF1RGeneProductENSG00000182578 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF2RAGeneProductENSG00000198223 (Ensembl)
CTLA4GeneProductENSG00000163599 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCR3GeneProductENSG00000186810 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
HLA-DRAGeneProductENSG00000204287 (Ensembl)
HLA-DRB1GeneProductENSG00000196126 (Ensembl)
IFITM2GeneProductENSG00000185201 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl)
LAG3GeneProductENSG00000089692 (Ensembl)
NRP1GeneProductENSG00000099250 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TRAGeneProduct6955 (Entrez Gene)
TRBGeneProduct6957 (Entrez Gene)
VEGFAGeneProductENSG00000112715 (Ensembl)
avβ6GeneProduct

Annotated Interactions

No annotated interactions

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