Steroid hormone precursor biosynthesis (Homo sapiens)

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1, 32IsoprogesteronePregnenetriolAKR1D120R,22R-dihydroxycholesterolGlucocorticoidsPregnenediol5beta-pregnane-3,20-dione3alpha-hydroxy-5beta-pregnan-20-one17alpha-hydroxyprogesterone17alpha-hydroxypregnenolonePregnanediol22R-HydroxycholesterolCYP11A1SRD5A111-deoxycorticosteroneAKR1C1 AllopregnanoloneCholesterol11-deoxycortisolSRD5A220alpha-HydroxyprogesteronePregnanediol-3-glucuronideMineralocorticoidsProgesteronePregnenoloneCYP21A25alpha-pregnane-3,20-dioneCYP11A1CYP11A1CYP17A1HSD3B2HSD3B1CYP17A1AKR1C1


Description

Biosynthesis of steroid hormone precursors. The enzymes responsible for this process are mainly cytochrome P450 (Cyps), hydroxysteroid dehydrogenases (HSDs), and steroid reductases, converting cholesterol to several classes of steroid hormones such as glucocorticoids, mineralocorticoids, progestins, androgens, and estrogens. these reactions take place in various organs, e.g. adrenal gland, testis, ovary, brain, placenta, and adipose tissue. [PMID:16807284] The pathway knowledge depicted in this model stems from William Griffths.

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Ontology Terms

 

Bibliography

  1. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH; ''Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.''; J Steroid Biochem Mol Biol, 2019 PubMed Europe PMC Scholia
  2. Chen M, Drury JE, Penning TM; ''Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1).''; Steroids, 2011 PubMed Europe PMC Scholia
  3. J Thomas Sanderson; ''The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals''; Toxicol Sci . , 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
124367view08:50, 20 October 2022DeSlOntology Term : 'C21-steroid hormone biosynthetic pathway' added !
124366view08:49, 20 October 2022DeSlOntology Term : 'steroid hormone biosynthetic pathway' added !
124365view08:48, 20 October 2022DeSlOntology Term : 'steroid biosynthetic pathway' added !
124364view08:46, 20 October 2022DeSlsmall layout changes to position of enzyme nodes
124363view08:45, 20 October 2022DeSlChanged width of reactions missing Rhea IDs slightly for better visualization on website
124361view08:43, 20 October 2022DeSlMade interactions with missing Rhea IDs thicker
124357view08:00, 20 October 2022DeSlUpdate layout, connected unconnected line
124354view07:53, 20 October 2022DeSlUpdated description, added reference
124329view14:04, 14 October 2022Conroy lipidsmove rhea IDs to right place
124328view13:26, 14 October 2022Conroy lipidsadd intermediate between pregnenolone and progesterone
124046view07:54, 15 September 2022DeSlOntology Term : 'classic metabolic pathway' added !
124045view07:54, 15 September 2022DeSlOntology Term : 'cholesterol metabolic pathway' added !
124000view10:49, 11 September 2022EgonwMade two pathways clickable
123946view08:45, 7 September 2022Conroy lipidsadd reactiopn
123942view13:46, 6 September 2022Conroy lipidsfixes
123941view13:42, 6 September 2022Conroy lipids
123938view15:49, 5 September 2022Conroy lipidsmore fixes
123937view14:59, 5 September 2022Conroy lipidsmove annotation from catalysis to covnversion (partial) add master ref
123804view07:31, 16 August 2022Conroy lipids
123803view07:28, 16 August 2022Conroy lipidsfixed typo, missing reaction/metbolite link
123797view11:29, 15 August 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
123796view11:28, 15 August 2022Conroy lipidsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11-deoxycorticosteroneMetaboliteLMST02030087 (LIPID MAPS)
11-deoxycortisolMetaboliteLMST02030086 (LIPID MAPS)
17alpha-hydroxypregnenoloneMetaboliteLMST02030089 (LIPID MAPS)
17alpha-hydroxyprogesteroneMetaboliteLMST02030161 (LIPID MAPS)
20R,22R-dihydroxycholesterolMetaboliteLMST01010200 (LIPID MAPS)
20alpha-HydroxyprogesteroneMetaboliteLMST02030169 (LIPID MAPS)
22R-HydroxycholesterolMetaboliteLMST01010086 (LIPID MAPS)
3alpha-hydroxy-5beta-pregnan-20-oneMetaboliteLMST02030175 (LIPID MAPS)
5alpha-pregnane-3,20-dioneMetaboliteLMST02030170 (LIPID MAPS)
5beta-pregnane-3,20-dioneMetaboliteLMST02030146 (LIPID MAPS)
AKR1C1 GeneProductQ04828 (Uniprot-TrEMBL)
AKR1D1GeneProductP51857 (Uniprot-TrEMBL)
AllopregnanoloneMetaboliteLMST02030130 (LIPID MAPS)
CYP11A1GeneProductP05108 (Uniprot-TrEMBL)
CYP17A1GeneProductP05093 (Uniprot-TrEMBL)
CYP21A2GeneProductP08686 (Uniprot-TrEMBL)
CholesterolMetaboliteLMST01010001 (LIPID MAPS)
GlucocorticoidsPathwayWP5280 (WikiPathways)
HSD3B1GeneProductP14060 (Uniprot-TrEMBL)
HSD3B2GeneProductP26439 (Uniprot-TrEMBL)
IsoprogesteroneMetaboliteLMST02030299 (LIPID MAPS)
MineralocorticoidsPathwayWP5279 (WikiPathways)
Pregnanediol-3-glucuronideMetaboliteLMST05010073 (LIPID MAPS)
PregnanediolMetaboliteLMST02030264 (LIPID MAPS)
PregnenediolMetaboliteLMST02030205 (LIPID MAPS)
PregnenetriolMetaboliteLMST02030263 (LIPID MAPS)
PregnenoloneMetaboliteLMST02030088 (LIPID MAPS)
ProgesteroneMetaboliteLMST02030159 (LIPID MAPS)
SRD5A1GeneProductP18405 (Uniprot-TrEMBL)
SRD5A2GeneProductP31213 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
17alpha-hydroxypregnenolone17alpha-hydroxyprogesteronemim-conversion24077 (Rhea) EC:1.1.1.145
17alpha-hydroxyprogesterone11-deoxycortisolmim-conversion50309 (Rhea) EC:1.14.14.16
20R,22R-dihydroxycholesterolPregnenolonemim-conversion34344 (Rhea) EC:1.14.15.6
22R-Hydroxycholesterol20R,22R-dihydroxycholesterolmim-conversion34340 (Rhea) EC:1.14.15.6
5alpha-pregnane-3,20-dioneAllopregnanolonemim-conversion41982 (Rhea)
5beta-pregnane-3,20-dione3alpha-hydroxy-5beta-pregnan-20-onemim-conversion69018 (Rhea)
Cholesterol22R-Hydroxycholesterolmim-conversion34336 (Rhea) EC:1.14.15.6
IsoprogesteroneProgesteronemim-conversion43929 (Rhea)
Pregnenolone17alpha-hydroxypregnenolonemim-conversion50237 (Rhea) EC 1.14.14.19
PregnenoloneIsoprogesteronemim-conversion43925 (Rhea)
Progesterone11-deoxycorticosteronemim-conversion50305 (Rhea) EC:1.14.14.16
Progesterone17alpha-hydroxyprogesteronemim-conversion46309 (Rhea) EC 1.14.14.19
Progesterone20alpha-Hydroxyprogesteronemim-conversion42114 (Rhea)
Progesterone5alpha-pregnane-3,20-dionemim-conversion21954 (Rhea) EC: 1.3.1.22
Progesterone5beta-pregnane-3,20-dionemim-conversion46661 (Rhea) EC:1.3.1.3
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