Estrogen metabolism (Homo sapiens)

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134232322UGT2A2CYP2C8CYP1A2Androstenedione2-hydroxyestroneSTSSULT1E1HSD17B14EstroneHSD17B4HSD17B84-MethoxyestradiolCYP3A5CYP2C94-HydroxyestradiolEstrone 3-glucuronideHSD17B24-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide)CYP3A7UGT1A10HSD17B104-MethoxyestroneHSD17B416alpha-Hydroxyestrone 3-O-beta-D-glucuronideCYP3A42-Methoxyestrone 3-glucuronideEstradiol16alpha-Hydroxyestrone 16-beta-D-glucuronide16alpha-hydroxyestroneHSD17B1HSD17B12-MethoxyestradiolCYP1B1TestosteroneCOMTestradiol glucuronateCYP19A1HSD17B3HSD17B2Estrone sulfateUGT2B7CYP1A12-HydroxyestradiolCYP2C19AKR1C34-Hydroxyestrone4-methoxyestrone 3-O-(beta-D-glucuronide)2-MethoxyestroneHSD17B7Estriol2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide)AKR1C3COMTCYP1B1CYP3A5CYP2C9CYP3A4CYP1A2CYP1A1CYP2C19CYP1B1CYP3A5CYP2C9CYP3A4CYP1A2CYP1A1UGT1A10UGT1A8UGT1A8


Description

Estrogen synthesis and metabolism. Data from W. Griffiths

Quality Tags

Ontology Terms

 

Bibliography

  1. Schiffer L, Barnard L, Baranowski ES, Gilligan LC, Taylor AE, Arlt W, Shackleton CHL, Storbeck KH; ''Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.''; J Steroid Biochem Mol Biol, 2019 PubMed Europe PMC Scholia
  2. Lépine J, Bernard O, Plante M, Têtu B, Pelletier G, Labrie F, Bélanger A, Guillemette C; ''Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium.''; J Clin Endocrinol Metab, 2004 PubMed Europe PMC Scholia
  3. Kallionpää RA, Järvinen E, Finel M; ''Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7.''; J Steroid Biochem Mol Biol, 2015 PubMed Europe PMC Scholia
  4. Sneitz N, Vahermo M, Mosorin J, Laakkonen L, Poirier D, Finel M; ''Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.''; Drug Metab Dispos, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124302view11:29, 12 October 2022Conroy lipidsadded a couple of missing rhea IDs
123930view09:06, 2 September 2022Conroy lipids
123929view08:26, 2 September 2022Conroy lipids
123928view06:50, 2 September 2022Conroy lipidsadd glucuronides, refs, rhea
123923view16:04, 31 August 2022Conroy lipidsadded refs, new glucuronid metabolites
123922view12:32, 31 August 2022Conroy lipidsadd glucuroniate, rheas, refs
123921view12:18, 31 August 2022Conroy lipidsadd overall ref and some Rhea IDs
123723view14:44, 11 August 2022Conroy lipids
123721view14:35, 11 August 2022Conroy lipidsmssing anchor
123719view14:29, 11 August 2022Conroy lipidsmissing anchor fixed
123712view13:46, 11 August 2022Conroy lipidsadd anchors to conversions
123708view09:29, 11 August 2022Conroy lipidsOntology Term : 'steroid biosynthetic pathway' added !
123707view09:28, 11 August 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
123706view09:28, 11 August 2022Conroy lipidsOntology Term : 'classic metabolic pathway' added !
123683view14:14, 9 August 2022EgonwFixed a datasource
123681view11:34, 9 August 2022Conroy lipidsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
16alpha-Hydroxyestrone 16-beta-D-glucuronideMetaboliteLMST05010069 (LIPID MAPS)
16alpha-Hydroxyestrone 3-O-beta-D-glucuronideMetaboliteLMST05010070 (LIPID MAPS)
16alpha-hydroxyestroneMetaboliteLMST02010041 (LIPID MAPS)
2-HydroxyestradiolMetaboliteLMST02010027 (LIPID MAPS)
2-MethoxyestradiolMetaboliteLMST02010035 (LIPID MAPS)
2-Methoxyestrone 3-glucuronideMetaboliteLMST05010010 (LIPID MAPS)
2-MethoxyestroneMetaboliteLMST02010033 (LIPID MAPS)
2-hydroxyestroneMetaboliteLMST02010032 (LIPID MAPS)
2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide)MetaboliteLMST05010009 (LIPID MAPS)
4-HydroxyestradiolMetaboliteLMST02010028 (LIPID MAPS)
4-HydroxyestroneMetaboliteLMST02010056 (LIPID MAPS)
4-MethoxyestradiolMetaboliteLMST02010055 (LIPID MAPS)
4-MethoxyestroneMetaboliteLMST02010057 (LIPID MAPS)
4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide)MetaboliteLMST05010072 (LIPID MAPS)
4-methoxyestrone 3-O-(beta-D-glucuronide)MetaboliteLMST05010071 (LIPID MAPS)
AKR1C3GeneProductP42330 (Uniprot-TrEMBL)
AndrostenedioneMetaboliteLMST02020007 (LIPID MAPS)
COMTGeneProductP21964 (Uniprot-TrEMBL)
CYP19A1GeneProductP11511 (Uniprot-TrEMBL)
CYP1A1GeneProductQ0VHD5 (Uniprot-TrEMBL)
CYP1A2GeneProductP05177 (Uniprot-TrEMBL)
CYP1B1GeneProductQ16678 (Uniprot-TrEMBL)
CYP2C19GeneProductP33261 (Uniprot-TrEMBL)
CYP2C8GeneProductP10632 (Uniprot-TrEMBL)
CYP2C9GeneProductP11712 (Uniprot-TrEMBL)
CYP3A4GeneProductP08684 (Uniprot-TrEMBL)
CYP3A5GeneProductP20815 (Uniprot-TrEMBL)
CYP3A7GeneProductP24462 (Uniprot-TrEMBL)
EstradiolMetaboliteLMST02010001 (LIPID MAPS)
EstriolMetaboliteLMST02010003 (LIPID MAPS)
Estrone 3-glucuronideMetaboliteLMST05010011 (LIPID MAPS)
Estrone sulfateMetaboliteLMST02010043 (LIPID MAPS)
EstroneMetaboliteLMST02010004 (LIPID MAPS)
HSD17B10GeneProductQ99714 (Uniprot-TrEMBL)
HSD17B14GeneProductQ9BPX1 (Uniprot-TrEMBL)
HSD17B1GeneProductP14061 (Uniprot-TrEMBL)
HSD17B2GeneProductP37059 (Uniprot-TrEMBL)
HSD17B3GeneProductP37058 (Uniprot-TrEMBL)
HSD17B4GeneProductP51659 (Uniprot-TrEMBL)
HSD17B7GeneProductP56937 (Uniprot-TrEMBL)
HSD17B8GeneProductQ92506 (Uniprot-TrEMBL)
STSGeneProductP08842 (Uniprot-TrEMBL)
SULT1E1GeneProductP49888 (Uniprot-TrEMBL)
TestosteroneMetaboliteLMST02020002 (LIPID MAPS)
UGT1A10GeneProductQ9HAW8 (Uniprot-TrEMBL)
UGT1A8GeneProductQ9HAW9 (Uniprot-TrEMBL)
UGT2A2GeneProductP0DTE5 (Uniprot-TrEMBL)
UGT2B7GeneProductP16662 (Uniprot-TrEMBL)
estradiol glucuronateMetaboliteLMST05010007 (LIPID MAPS)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
16alpha-Hydroxyestrone 3-O-beta-D-glucuronidemim-conversion52449 (Rhea) EC:2.4.1.17
16alpha-hydroxyestrone16alpha-Hydroxyestrone 16-beta-D-glucuronidemim-conversion52453 (Rhea) EC:2.4.1.17
2-Hydroxyestradiol2-Methoxyestradiolmim-conversion53089 (Rhea) EC:2.1.1.6
2-Methoxyestradiol2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide)mim-conversion53081 (Rhea) EC:2.4.1.17
2-Methoxyestrone2-Methoxyestrone 3-glucuronidemim-conversion53065 (Rhea) EC:2.4.1.17
2-hydroxyestrone2-Methoxyestronemim-conversion53101 (Rhea) EC:2.1.1.6
4-Hydroxyestradiol4-Methoxyestradiolmim-conversion53097 (Rhea) EC:2.1.1.6
4-Hydroxyestrone4-Methoxyestronemim-conversion53105 (Rhea) EC:2.1.1.6
4-Methoxyestradiol4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide)mim-conversion53073 (Rhea) EC:2.4.1.17
4-Methoxyestrone4-methoxyestrone 3-O-(beta-D-glucuronide)mim-conversion53069 (Rhea) EC:2.4.1.17
AndrostenedioneEstronemim-conversion38196 (Rhea) EC:1.14.14.14
AndrostenedioneTestosteronemim-conversion14931 (Rhea)
Estradiol2-Hydroxyestradiolmim-conversion47213 (Rhea) EC:1.14.14.1
Estradiol4-Hydroxyestradiolmim-conversion47281 (Rhea) EC:1.14.14.1
EstradiolEstriolmim-conversion47333 (Rhea) EC:1.14.14.1
EstradiolEstronemim-conversion24612 (Rhea)
Estradiolestradiol glucuronatemim-conversion52461 (Rhea) EC:2.4.1.17
Estrone sulfateEstronemim-conversion31056 (Rhea) EC:3.1.6.2
Estrone16alpha-hydroxyestronemim-conversion47205 (Rhea) EC:1.14.14.1
Estrone2-hydroxyestronemim-conversion47209 (Rhea) EC:1.14.13
Estrone4-Hydroxyestronemim-conversion47293 (Rhea) EC:1.14.14.1
EstroneEstradiolmim-conversion24618 (Rhea)
EstroneEstrone 3-glucuronidemim-conversion52477 (Rhea) EC:2.4.1.17
EstroneEstrone sulfatemim-conversion15974 (Rhea) EC:2.8.2.4
TestosteroneAndrostenedionemim-conversion14930 (Rhea) EC:1.1.1.51
TestosteroneEstradiolmim-conversion38192 (Rhea) EC:1.14.14.14
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