Farnesyl to CoQ10 metabolism (Homo sapiens)

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1, 211111Decarprenyl-PP4OH-phenyllactateRiboflavin and CoQ metabolism4OH-phenylpyruvateCoQ10Mevalonate pathwaytyrosineTrans-prenyl transferase4OH-CinnamateDecaprenyl-4OH-benzoateFarnesyl-PP11111114OH-benzoate111


Description

Coenzyme Q (ubiquinone or CoQ) is an essential lipid in electron transport and an important antioxidant. CoQ synthesis derives from the isoprene biosynthetic pathway in human and yeast cells. There is interest in the use of CoQ10 in particular for the treatment of mitochondrial disorders and neurodegenerative diseases [PMID: 17973981].

Quality Tags

Ontology Terms

 

Bibliography

  1. Iain P Hargreaves; '' Ubiquinone: cholesterol's reclusive cousin''; Ann Clin Biochem., 2003 PubMed Europe PMC Scholia
  2. Manuel J Acosta Lopez, Eva Trevisson, Marcella Canton, Luis Vazquez-Fonseca, Valeria Morbidoni, Elisa Baschiera, Chiara Frasson, Ludovic Pelosi, Bérengère Rascalou, Maria Andrea Desbats, María Alcázar-Fabra, José Julián Ríos, Alicia Sánchez-García, Giuseppe Basso, Placido Navas, Fabien Pierrel, Gloria Brea-Calvo, Leonardo Salviati; ''Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6''; Oxid Med Cell Longev . , 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123603view14:53, 4 August 2022DeSlAdded another refrence for PW
123602view14:40, 4 August 2022DeSlOntology Term : 'isoprenoid biosynthetic pathway' added !
123601view14:40, 4 August 2022DeSlOntology Term : 'metabolic pathway of cofactors, vitamins, nutrients' added !
123600view14:38, 4 August 2022DeSlOntology Term : 'classic metabolic pathway' added !
123598view14:24, 4 August 2022DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
4OH-CinnamateMetabolite637542 (PubChem-compound) AKA 4-Hydroxycinnamic acid
4OH-benzoateMetabolite135 (PubChem-compound) AKA 4-Hydroxybenzoic acid
4OH-phenyllactateMetaboliteHMDB0000755 (HMDB)
  • AKA 4-Hydroxyphenyllactate
  • Hydroxyphenyllactic acid is a tyrosine metabolite. It is carcinogenic. The level of hydroxyphenyllactic acid is elevated in patients with deficiency of the enzyme p-hydroxyphenylpyruvate oxidase (EC 1.14.2.2) PMID:4720815]
4OH-phenylpyruvateMetaboliteCHEBI:15999 (ChEBI) AKA 4-Hydroxyphenylpyruvic acid (4-HPPA)
CoQ10MetaboliteCHEBI:46245 (ChEBI)
Decaprenyl-4OH-benzoateMetabolite6454686 (PubChem-compound) AKA Decaprenyl-4-hydroxybenzoate
Decarprenyl-PPMetabolite46173330 (PubChem-compound) AKA decarprenyl pyrophosphate
Farnesyl-PPMetabolite175763 (ChEBI)
Mevalonate pathwayPathwayWP4190 (WikiPathways)
Riboflavin and CoQ metabolismPathwayWP5037 (WikiPathways)
Trans-prenyl transferaseProtein2.5.1.- (Enzyme Nomenclature) Might be 2.5.1.90 and/or 2.5.1.91
tyrosineMetaboliteCHEBI:18186 (ChEBI)

Annotated Interactions

No annotated interactions

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