LDL- influence on CD14 and TLR4 (Homo sapiens)

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nucleusP38 MAPK (14)PP38 MAPK (12)PP38 MAPK (13)PP38 MAPK (11)P1 MonocyteCytokineReleaseNF-κBCytoplasmCREBi measured in study[PMID:27235719]IL10NFKB1CD14AKTCREB1P38 MAPK (11)PI3KTLR4LDL-AP-1P38 MAPK (12)P38 MAPK (13)P38 MAPK (14)MCP1IL6IL1-betaIL10IL6MCP1IL1-betaIL6IL1-betaIL10MCP1Extracellular mediaCREB2CREB3CREB5CREB3L1CREB3L2CREB3L3CREB3L4RELANFKB2RELBREL


Electronegative LDL (LDL(-)) is a plasma LDL subfraction inducing induces cytokine release in monocytes by activating TLR4. The subsequent phosphorylation of p38 MAPK phosphorylation (which is higher compared to native LDL) through TLR4 and PI3k/Akt pathways activates NF-kB, AP-1 and CREB. These last three have a direct effect on four cytokines (IL1beta, IL6, IL10 and MCP1), with bold black letters for the highest level of cytokine induction, gray letters for the lowest level and regular letter for the intermediate induction.

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Ontology Terms



  1. Montserrat Estruch, Jose Luis Sanchez-Quesada, Jordi Ordoñez-Llanos, Sonia Benitez; ''Inflammatory intracellular pathways activated by electronegative LDL in monocytes''; Biochim Biophys Acta ., 2016 PubMed Europe PMC Scholia


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123542view11:47, 3 August 2022DeSlAdded ChEBI ID for LDL-
123478view15:00, 28 July 2022DeSlOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
123477view15:00, 28 July 2022DeSlOntology Term : 'phosphatidylinositol 3-kinase signaling pathway' added !
123476view14:59, 28 July 2022DeSlOntology Term : 'Interleukin-10 signaling pathway' added !
123475view14:59, 28 July 2022DeSlOntology Term : 'interleukin-1 family mediated signaling pathway' added !
123474view14:58, 28 July 2022DeSlOntology Term : 'signaling pathway' added !
123473view14:58, 28 July 2022DeSlOntology Term : 'Interleukin mediated signaling pathway' added !
123472view14:58, 28 July 2022DeSlOntology Term : 'cytokine mediated signaling pathway' added !
123471view14:57, 28 July 2022DeSlOntology Term : 'monocyte' added !
123470view14:57, 28 July 2022DeSlAdded all individual proteins for NFKB complex
123469view14:50, 28 July 2022DeSlAdding individual CREB (like) proteins
123468view14:44, 28 July 2022DeSlAdding phosphorylation of P38 MAPK
123467view14:37, 28 July 2022DeSlAdded Cytokine release visualization
123466view14:36, 28 July 2022DeSlUpdate cytokine visualization
123465view14:35, 28 July 2022DeSlAdded ref and description
123464view14:26, 28 July 2022DeSlAdded MCP1 (aka CCL2) annotation
123463view13:17, 28 July 2022DeSlAdded nucleus, cytoplasm info
123462view13:14, 28 July 2022DeSlAdd monocyte, comment on LDL-
123461view12:38, 28 July 2022DeSlNew pathway

External references


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NameTypeDatabase referenceComment
AKTProteinENSG00000142208 (Ensembl)
AP-1ProteinIPR000837 (InterPro)
CD14ProteinP08571 (Uniprot-TrEMBL)
CREB1ProteinP16220 (Uniprot-TrEMBL)
CREB2ProteinP18848 (Uniprot-TrEMBL) AKA ATF4
CREB3L1ProteinQ96BA8 (Uniprot-TrEMBL)
CREB3L2ProteinQ70SY1 (Uniprot-TrEMBL)
CREB3L3ProteinQ68CJ9 (Uniprot-TrEMBL)
CREB3L4ProteinQ8TEY5 (Uniprot-TrEMBL)
CREB3ProteinO43889 (Uniprot-TrEMBL)
CREB5ProteinQ02930 (Uniprot-TrEMBL)
IL1-betaGeneProductENSG00000125538 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
LDL-MetaboliteCHEBI:192800 (ChEBI) High content in Cer, Sph, NEFA
MCP1GeneProductP13500 (Uniprot-TrEMBL)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKB2ProteinQ00653 (Uniprot-TrEMBL)
P38 MAPK (11)ProteinQ15759 (Uniprot-TrEMBL)
P38 MAPK (12)ProteinP53778 (Uniprot-TrEMBL)
P38 MAPK (13)ProteinO15264 (Uniprot-TrEMBL)
P38 MAPK (14)ProteinQ16539 (Uniprot-TrEMBL)
PI3KProteinIPR000403 (InterPro)
RELAProteinQ04206 (Uniprot-TrEMBL)
RELBProteinQ01201 (Uniprot-TrEMBL)
RELProteinQ04864 (Uniprot-TrEMBL)
TLR4ProteinO00206 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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