Comprehensive IL-17A signaling pathway (Mus musculus)

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Airway epithelial cells 1Inflammation, apoptosis, and migration Human bronchial epithelial (HBE) cellsIL-17A mediated pulmonary SMAD- dependent and non-dependent mechanism during acute lung injury in vivoTransforming growth factor beta signalingAlveolar basal epithelial A549 cells DissociationProteinChemokine ligands InterleukinsBleomycin-induced pulmonary fibrotic mice modelPulmonary inflammation and fibrosis Minichromosome maintenance (MCM) proteins invovled in DNA replicationIL-11EgfrUpf1Zmpste24Ccl3Cxcl5Orc2Fn1Ccl5Rbbp4Serpine1TNFSrpk2VCANCCL2 TGFB1CXCL1Cdc42Cdc42CXCL8Acta1Pole3Rac1CrebbpParp1PlaurCasp3HSPG2Samhd1CacybpACTA2Cxcl1Cxcl12CSF3COL5A2Ccl4AtrxOrc1IL-6LIFDhx9PlauMUC5ACCOL3A1Npm1NaspPcnaPuraNucks1IL-10CXCL2Sqstm1Acta2Igf1Acta2Map1lc3bBaffFbn1Bcl2IL1BHspa1bSnai1Mki67Mcm7Adh1Hmgb1Smad6Col1a1PdgfbHbb-bh1Sod2Stat1Y701Plch1mTORS2448CXCL5Smad2S465S467P53IL17RAPrkacbMAPK1PPRKAA1MAPK3PAnxa6PlauIl1bPtgs2CXCL6Mmp3PI3KCAY458Y199Becn1Stat1Akt1S473IL17ACcn2IL17RARac1MAPK14MtorMylkGng12Uggt1Stat3Y705Il6RELAS536Mcm5Casp3PdgfaRab10Serpine1RELAS536Cpne1NFKB1Map1lc3aNFKBIAC3Arpc2Smad7 CXCL1RELAEgfrY1068NFKB1BECN1 NFKBIAPik3c3CFBActa2Cxcl1Hbb-b2Col1a1BCL2Psmc6PlaurRelaMcm4Mcm6GSK3BS9Particulate matter (PM2.5)CXCL3Bleomycin induced IL-17A activationMcm2Tgfb1Ppp1r14bBlmhSnai2IL8Experimental silica treatment in miceP53RhoaAutophagyPak3GRK5Il1bIL6C7 Mmp14Arpc3Gap43Mcm3Smad3S423S425Degrease kinase activity GSK3BmTORS2448IL17APIK3CAPInhibit autophagy in pulmonary fibrosis Acta2Inflammatory neutrophils in the bronchoalveolar space Rras2Arpc5Atox1Hyou1FibrosisPon3IL-17A stimulationAngpt1IL-17ACxcl12 IL17RAMmp9Cxcl2Hbb-b1Tgfb1Smad2S465S467Smad3S425S423Jak2Y1008Y1007Jak1Y1035Y1034Stat3Y705Acute lung injurySTAT1/3 mediated transcriptionalregulationMAPK1PMAPK3PmTORStat3IL-17AIL17RAJak2Y1007Y1008Jak1Y1035Y1034P53PAkt1PMAPK14T183Y185Bleomycin induced IL-17A activationUnilateral Ureteral Obstruction (UUO) injuryIL-17A stimulationIL-17AIL17RANFKB1NFKBIAPChronic airway diseasesIL-17A stimulationReceptorProteinmRNALigand Inhibition Leads to through multiple reactionsLEGEND IL-17A stimulation Bleomycin induced IL-17A activationSmad3S423S425DissociationStat3Y705Stat1Y701Stat3Y705 Translocation Nucleus Cytoplasm Plasma membraneCYPMNU ExtracellularECGene/ProteinGene/Protein Upregulation Downregulation PhosphorylationDissociationNUCYNUCYNUCYNUCYActivationGram-negative bacterial pneumonia infection Proliferation of asthmatic fibrocytes AsthmaIL-10ACTA2Extracellular matrix deposition and neovascularization Apoptosis and injury Bleomycin induced miceDegradation of BCL-2Human lung epithelial cellsBCL2S70Renal fibrosisSilicosis lung inflammation in miceSnai1Col1a1Snai2Tjp1Cdh1Epithelial-mesenchymal transition (EMT) markersHuman primary small airway epithelial cellsMouse alveolar epithelial (MLE-12) cells Jak2PJak1PParticulate matter (PM2.5) stimulationExperimental silica treatment in miceP


Description

Schematic representation of IL-17A signaling pathway with a mix of human and mouse genes/proteins based on literature review.

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Ontology Terms

 

Bibliography

  1. Rex DAB, Dagamajalu S, Gouda MM, Suchitha GP, Chanderasekaran J, Raju R, Prasad TSK, Bhandary YP; ''A comprehensive network map of IL-17A signaling pathway.''; J Cell Commun Signal, 2022 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
124477view21:23, 30 October 2022AlexanderPicoModified description
124476view21:22, 30 October 2022AlexanderPicomore xrefs
124475view21:15, 30 October 2022AlexanderPicoremoved off-map nodes; added ref
124474view21:13, 30 October 2022AlexanderPicocompleted xrefs; fixed legend to use labels
123976view10:33, 9 September 2022EweitzModified title
123802view18:04, 15 August 2022KhanspersOntology Term : 'interleukin-17 family mediated signaling pathway' added !
123801view18:04, 15 August 2022KhanspersOntology Term : 'signaling pathway' added !
123125view04:40, 5 July 2022EgonwWorked on the data sources
123092view08:08, 29 June 2022Rex D A BAnnotations
123091view07:35, 29 June 2022Rex D A BAlignment
123090view06:32, 28 June 2022Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTA2GeneProduct59 (Entrez Gene)
Acta1GeneProduct11459 (Entrez Gene)
Acta2GeneProduct11475 (Entrez Gene)
Adh1GeneProduct11522 (Entrez Gene)
Akt1GeneProduct207 (Entrez Gene)
Akt1ProteinP31750 (Uniprot-TrEMBL)
Angpt1GeneProductENSMUSG00000022309 (Ensembl)
Anxa6GeneProduct11749 (Entrez Gene)
Arpc2GeneProduct76709 (Entrez Gene)
Arpc3GeneProduct56378 (Entrez Gene)
Arpc5GeneProduct67771 (Entrez Gene)
Atox1GeneProduct11927 (Entrez Gene)
AtrxProteinQ61687 (Uniprot-TrEMBL)
BCL2ProteinP10415.2 (Uniprot-TrEMBL)
BECN1 ProteinQ14457.2 (Uniprot-TrEMBL)
BaffGeneProduct24099 (Entrez Gene)
Bcl2ProteinP10417 (Uniprot-TrEMBL)
Becn1ProteinO88597 (Uniprot-TrEMBL)
BlmhGeneProduct104184 (Entrez Gene)
C3GeneProduct12266 (Entrez Gene)
C7 GeneProduct109828 (Entrez Gene)
CCL2 ProteinP13500 (Uniprot-TrEMBL)
CFBGeneProduct629 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
COL5A2GeneProduct1290 (Entrez Gene)
CSF3ProteinP09919 (Uniprot-TrEMBL)
CXCL1GeneProduct2919 (Entrez Gene)
CXCL1ProteinP09341 (Uniprot-TrEMBL)
CXCL2GeneProduct2920 (Entrez Gene)
CXCL3GeneProduct2921 (Entrez Gene)
CXCL5GeneProduct20311 (Entrez Gene)
CXCL6GeneProduct6372 (Entrez Gene)
CXCL8ProteinP10145 (Uniprot-TrEMBL)
CacybpProteinQ9CXW3 (Uniprot-TrEMBL)
Casp3GeneProduct12367 (Entrez Gene)
Casp3ProteinP05122 (Uniprot-TrEMBL)
Ccl3GeneProduct20302 (Entrez Gene)
Ccl4GeneProduct20303 (Entrez Gene)
Ccl5GeneProduct20304 (Entrez Gene)
Ccn2GeneProduct14219 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Cdc42ProteinP60766 (Uniprot-TrEMBL)
Cdh1ProteinP09803 (Uniprot-TrEMBL)
Col1a1GeneProduct12842 (Entrez Gene)
Col1a1ProteinP02452 (Uniprot-TrEMBL)
Cpne1GeneProduct266692 (Entrez Gene)
CrebbpGeneProductP45481 (Uniprot-TrEMBL)
Cxcl1GeneProduct14825 (Entrez Gene)
Cxcl12 ProteinP40224 (Uniprot-TrEMBL)
Cxcl12GeneProduct20315 (Entrez Gene)
Cxcl2GeneProduct20310 (Entrez Gene)
Cxcl5GeneProduct20311 (Entrez Gene)
Dhx9ProteinO70133 (Uniprot-TrEMBL)
EgfrProteinQ01279 (Uniprot-TrEMBL)
Fbn1GeneProduct14118 (Entrez Gene)
Fn1GeneProduct14268 (Entrez Gene)
GRK5GeneProduct2869 (Entrez Gene)
GSK3BProteinP49841 (Uniprot-TrEMBL)
Gap43GeneProduct14432 (Entrez Gene)
Gng12GeneProduct14701 (Entrez Gene)
HSPG2GeneProduct3339 (Entrez Gene)
Hbb-b1GeneProduct15129 (Entrez Gene)
Hbb-b2GeneProduct15130 (Entrez Gene)
Hbb-bh1GeneProduct15132 (Entrez Gene)
Hmgb1GeneProduct15289 (Entrez Gene)
Hspa1bGeneProduct15511 (Entrez Gene)
Hyou1GeneProduct12282 (Entrez Gene)
IL-10ProteinP22301 (Uniprot-TrEMBL)
IL-11ProteinP20809 (Uniprot-TrEMBL)
IL-17AGeneProduct3605 (Entrez Gene)
IL-6ProteinP05231 (Uniprot-TrEMBL)
IL17AGeneProduct3605 (Entrez Gene)
IL17RAGeneProduct23765 (Entrez Gene)
IL1BGeneProductP01584.2 (Uniprot-TrEMBL)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct20309 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Il1bGeneProduct16176 (Entrez Gene)
Il1bGeneProductP10749 (Uniprot-TrEMBL)
Il6GeneProduct16193 (Entrez Gene)
Jak1ProteinP23458 (Uniprot-TrEMBL)
Jak1ProteinP52332 (Uniprot-TrEMBL)
Jak2ProteinO60674 (Uniprot-TrEMBL)
Jak2ProteinQ62120 (Uniprot-TrEMBL)
LIFProteinP15018 (Uniprot-TrEMBL)
MAPK14GeneProduct1432 (Entrez Gene) p38
MAPK14ProteinQ16539 (Uniprot-TrEMBL) p38
MAPK1GeneProduct5594 (Entrez Gene) p38
MAPK1ProteinP28482 (Uniprot-TrEMBL) p38
MAPK3GeneProduct5595 (Entrez Gene)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MUC5ACGeneProduct4586 (Entrez Gene)
Map1lc3aProteinQ91VR7 (Uniprot-TrEMBL)
Map1lc3bProteinQ9CQV6 (Uniprot-TrEMBL)
Mcm2ProteinP97310 (Uniprot-TrEMBL)
Mcm3ProteinP25206 (Uniprot-TrEMBL)
Mcm4Protein17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6ProteinP97311 (Uniprot-TrEMBL)
Mcm7GeneProductQ61881 (Uniprot-TrEMBL)
Mki67GeneProduct17345 (Entrez Gene)
Mmp14GeneProduct17387 (Entrez Gene)
Mmp3GeneProduct17392 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
MylkGeneProduct107589 (Entrez Gene)
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKBIAGeneProduct4792 (Entrez Gene)
NaspProteinQ99MD9 (Uniprot-TrEMBL)
Npm1ProteinQ61937 (Uniprot-TrEMBL)
Nucks1ProteinQ80XU3 (Uniprot-TrEMBL)
Orc1ProteinQ9Z1N2 (Uniprot-TrEMBL)
Orc2ProteinQ60862 (Uniprot-TrEMBL)
P53GeneProduct22059 (Entrez Gene)
P53ProteinP04637 (Uniprot-TrEMBL)
PI3KCAProtein5290 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PRKAA1ProteinQ13131 (Uniprot-TrEMBL)
Pak3GeneProduct18481 (Entrez Gene)
Parp1ProteinP11103 (Uniprot-TrEMBL)
PcnaProteinP17918 (Uniprot-TrEMBL)
PdgfaGeneProduct18590 (Entrez Gene)
PdgfbGeneProduct18591 (Entrez Gene)
Pik3c3ProteinQ6PF93 (Uniprot-TrEMBL)
PlauGeneProduct18792 (Entrez Gene)
PlauProteinP06869 (Uniprot-TrEMBL)
PlaurGeneProduct18793 (Entrez Gene)
PlaurProteinP35456 (Uniprot-TrEMBL)
Plch1GeneProduct269437 (Entrez Gene)
Pole3ProteinQ9JKP7 (Uniprot-TrEMBL)
Pon3GeneProductENSMUSG00000029759 (Ensembl)
Ppp1r14bGeneProduct18938 (Entrez Gene)
PrkacbGeneProduct18749 (Entrez Gene)
Psmc6GeneProduct67089 (Entrez Gene)
Ptgs2GeneProduct19225 (Entrez Gene)
PuraProteinP42669 (Uniprot-TrEMBL)
RELAProteinQ04206 (Uniprot-TrEMBL)
Rab10GeneProduct19325 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Rac1ProteinP63001 (Uniprot-TrEMBL)
Rbbp4ProteinQ60972 (Uniprot-TrEMBL)
RelaGeneProduct19697 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Rras2GeneProduct66922 (Entrez Gene)
Samhd1ProteinQ60710 (Uniprot-TrEMBL)
Serpine1GeneProduct66870 (Entrez Gene)
Serpine1ProteinP05121 (Uniprot-TrEMBL)
Smad2Protein17126 (Entrez Gene)
Smad2ProteinQ62432 (Uniprot-TrEMBL)
Smad3Protein17127 (Uniprot-TrEMBL)
Smad3ProteinQ8BUN5 (Uniprot-TrEMBL)
Smad6ProteinO35182 (Uniprot-TrEMBL)
Smad7 ProteinO35253 (Uniprot-TrEMBL)
Snai1ProteinQ02085 (Uniprot-TrEMBL)
Snai2ProteinP97469 (Uniprot-TrEMBL)
Sod2GeneProduct20656 (Entrez Gene)
Sqstm1ProteinQ64337 (Uniprot-TrEMBL)
Srpk2ProteinO54781 (Uniprot-TrEMBL)
Stat1GeneProduct20846 (Entrez Gene)
Stat1ProteinP42225 (Uniprot-TrEMBL)
Stat3ProteinP42227 (Uniprot-TrEMBL)
TGFB1GeneProduct7040 (Entrez Gene)
TNFProteinP01375 (Uniprot-TrEMBL)
Tgfb1ProteinP04202 (Uniprot-TrEMBL)
Tjp1ProteinP39447 (Uniprot-TrEMBL)
Uggt1GeneProduct320011 (Entrez Gene)
Upf1ProteinQ9EPU0 (Uniprot-TrEMBL)
VCANGeneProduct1462 (Entrez Gene)
Zmpste24ProteinQ80W54 (Uniprot-TrEMBL)
mTORProteinP42345.1 (Uniprot-TrEMBL)
mTORProteinQ9JLN9 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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