Hippocampal synaptogenesis and neurogenesis (Homo sapiens)

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2CaMKII CytokinesGrowth factors Regulation of multiplepostsynaptic and presynaptic proteins through phosphorylation(e.g. neurotransmitter synthesis, cytoskeletal regulation, calcium channelregulation) ATPCa2+PRKCA DRD1 Thyroxine (T4)Voltage-gated Ca2+ channel AMPA NMDA cAMPCREB1Ca2+Ca2+Ca2+Ca2+Ca2+Ca2+Na+K+CALM1CAMK2A CAMK2BCAMKK1 CAMKK2CaMKKCAMK4 CAMK4 PRKCATrkBMAPK14MAPK/ERKRSKRSKRPS6KA5Adult hippocampal neurogenesis Memory cognition(spatial memory, recognition memory, fear memory,pattern discrimination)Triiodothyronine (T3)Thyroxine (T4)DIO2NRXN1 NRXN2 11NRXN3 SYT2 1SYT121Ca2+ dependent synaptic remodeling11BDNF NCAM1 PRLBCL2NGF CCND2 Ca2+ dependent expression of neurogenic genes HNRNPLHippocampal neuron3PPARGC1A3Regulation of calcium homeostasisin neuronal cells. Influences brain development3


Cognitive function and the consolidation of memory through hippocampal synaptogenesis and neurogenesis and the role of thyroxine.

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Ontology Terms



  1. Krebs J; ''The Influence of Thyroid Hormone on Ca2+Signaling Pathways During Embryonal Development.''; Curr Top Med Chem, 2021 PubMed Europe PMC Scholia
  2. Ortega-Martínez S; ''A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis.''; Front Mol Neurosci, 2015 PubMed Europe PMC Scholia
  3. Krebs J; ''Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.''; Biochim Biophys Acta Mol Cell Res, 2017 PubMed Europe PMC Scholia


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123335view19:22, 16 July 2022AlexanderPicoOntology Term : 'hippocampal neuron' added !
123334view19:22, 16 July 2022AlexanderPicoOntology Term : 'signaling pathway' added !
123333view19:22, 16 July 2022AlexanderPicoOntology Term : 'regulatory pathway' added !
123332view19:22, 16 July 2022AlexanderPicoOntology Term : 'synaptic differentiation pathway' added !
123331view19:21, 16 July 2022AlexanderPicoOntology Term : 'signaling pathway pertinent to development' added !
123330view19:19, 16 July 2022AlexanderPicoModified title
123329view19:19, 16 July 2022AlexanderPicoModified description
122750view09:33, 9 May 2022CMalyarFixed unconnected arrow
122749view09:32, 9 May 2022CMalyarModified arrow
122748view09:25, 9 May 2022CMalyarAdded anchor
122732view20:19, 6 May 2022CMalyarModified identifiers
122731view20:19, 6 May 2022CMalyarModified identifiers
122730view13:38, 6 May 2022CMalyarAddition of genes downstream of T3 (Neurexin, SYT2,SYT12, PMCA1a, HNRNPL). New references.
122705view10:08, 4 May 2022EgonwNormalized the Ensembl data source
122699view14:35, 3 May 2022CMalyar
122698view14:35, 3 May 2022CMalyar
122697view14:33, 3 May 2022CMalyarNew pathway

External references


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NameTypeDatabase referenceComment
AMPA ComplexR-HSA-9620484 (Reactome)
ATPMetabolite30616 (ChEBI)
BCL2ProteinENSG00000171791 (Ensembl)
BDNF ProteinENSG00000176697 (Ensembl)
CALM1 ProteinENSG00000198668 (Ensembl)
CAMK2A ProteinENSG00000070808 (Ensembl)
CAMK2B ProteinENSG00000058404 (Ensembl)
CAMK4 ProteinENSG00000152495 (Ensembl)
CAMK4 ProteinHGNC:1464 (HGNC)
CAMKK1 ProteinENSG00000004660 (Ensembl)
CAMKK2 ProteinENSG00000110931 (Ensembl)
CCND2 ProteinENSG00000118971 (Ensembl)
CREB1ProteinP16220 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DIO2 ProteinENSG00000211448 (Ensembl)
DRD1 GeneProductENSG00000184845 (Ensembl)
HNRNPL ProteinENSG00000104824 (Ensembl)
K+MetaboliteCHEBI:29103 (ChEBI)
MAPK/ERK ProteinENSG00000100030 (Ensembl)
MAPK14ProteinENSG00000112062 (Ensembl)
NCAM1 ProteinENSG00000149294 (Ensembl)
NGF ProteinENSG00000134259 (Ensembl)
NMDA ComplexR-HSA-884990 (Reactome)
NRXN1 ProteinENSG00000179915 (Ensembl)
NRXN2 ProteinENSG00000110076 (Ensembl)
NRXN3 ProteinENSG00000021645 (Ensembl)
Na+MetaboliteCHEBI:29101 (ChEBI)
PPARGC1AProteinENSG00000109819 (Ensembl)
PRKCA ProteinENSG00000154229 (Ensembl)
PRKCA ProteinHGNC:9393 (HGNC)
PRLProteinENSG00000172179 (Ensembl)
RPS6KA5ProteinENSG00000100784 (Ensembl)
RSK ProteinENSG00000117676 (Ensembl)
SYT12ProteinENSG00000173227 (Ensembl)
SYT2 ProteinENSG00000143858 (Ensembl)
Thyroxine (T4)MetaboliteHMDB0000248 (HMDB)
Triiodothyronine (T3)Metabolite5707 (Chemspider)
TrkBGeneProductW8VY28 (Uniprot-TrEMBL)
Voltage-gated Ca2+ channel ComplexR-HSA-210378 (Reactome)
cAMPMetabolite17489 (ChEBI)

Annotated Interactions

No annotated interactions

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