Nephrotoxcicity adverse outcome pathway (Homo sapiens)

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1, 2KE1633: Increase in inflammationDNA repair pathways, full networkDNA damage responseKE1194: Increase, DNA DamageOxidative damage responseKE55: Cell injury/deathElectron transport chain: OXPHOS system in mitochondriaKE1968: Increase, Mitochondrial DysfunctionFerroptosisKE1496: Increased, secretion of proinflammatory mediatorsSLC31A1KE1262: ApoptosisUnfolded protein responseOxidative stress responseToll-like receptor signaling pathwayKE1923: Altered gene expression, P53 dependent apoptosis pathwayCytokines and inflammatory responseInflammatory response pathwayKE1848: Toll Like Receptor (TLR) Dysregulationp53 transcriptional gene networkSLC22A2Apoptosis modulation and signalingKE1115: Increased, Reactive oygen speciesRIPK1-mediated regulated necrosisAutophagyApoptosis modulation and signalingTLR4 signaling and toleranceOverview of proinflammatory and profibrotic mediatorsKE814: Occurence, Kidney ToxicityKE1815: Activation of ER stress


Adverse outcome pathway showing the events of nephrotoxicity leading to tubular cell injury and death.

Quality Tags

Ontology Terms



  1. Manohar S, Leung N; ''Cisplatin nephrotoxicity: a review of the literature.''; J Nephrol, 2018 PubMed Europe PMC Scholia
  2. Perazella MA, Rosner MH; ''Drug-Induced Acute Kidney Injury.''; Clin J Am Soc Nephrol, 2022 PubMed Europe PMC Scholia


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123080view17:34, 26 June 2022JuliajohnssonChanged arrow
123079view14:10, 24 June 2022Juliajohnssonannotated key event
123078view14:03, 24 June 2022JuliajohnssonAdded key event
122984view10:54, 9 June 2022Juliajohnssonfixed pathway interaction
122918view21:29, 2 June 2022JuliajohnssonAdded gene name
122752view10:33, 9 May 2022JuliajohnssonAdded gene name.
122712view13:38, 4 May 2022JuliajohnssonFixed interactions
122707view13:21, 4 May 2022JuliajohnssonChnaged pathway node to event node
122706view13:16, 4 May 2022JuliajohnssonChanged empty type columns to events
122700view14:50, 3 May 2022Marvin M2created event node
122696view14:02, 3 May 2022JuliajohnssonModified description
122695view13:54, 3 May 2022JuliajohnssonAdded literature and fixed interactions.
122689view14:46, 2 May 2022JuliajohnssonOntology Term : 'CL:1000497' removed !
122688view14:46, 2 May 2022JuliajohnssonOntology Term : 'DOID:0050855' removed !
122687view14:46, 2 May 2022JuliajohnssonOntology Term : 'DOID:557' removed !
122686view14:44, 2 May 2022JuliajohnssonOntology Term : 'renal fibrosis' added !
122685view14:40, 2 May 2022JuliajohnssonOntology Term : 'kidney disease' added !
122684view14:36, 2 May 2022JuliajohnssonOntology Term : 'chronic kidney disease' added !
122683view14:35, 2 May 2022JuliajohnssonOntology Term : 'kidney tubule cell' added !
122682view14:34, 2 May 2022JuliajohnssonOntology Term : 'acute kidney tubular necrosis' added !
122681view14:31, 2 May 2022JuliajohnssonModified description
122680view11:04, 2 May 2022Juliajohnssonupdated one key event
122679view10:52, 2 May 2022Juliajohnssonupdated key events
122678view10:30, 2 May 2022JuliajohnssonOntology Term : 'kidney cell' added !
122677view10:29, 2 May 2022JuliajohnssonNew pathway

External references


View all...
NameTypeDatabase referenceComment
Apoptosis modulation and signalingPathwayWP1772 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
Cytokines and inflammatory responsePathwayWP530 (WikiPathways)
DNA damage responsePathwayWP707 (WikiPathways)
DNA repair pathways, full networkPathwayWP4946 (WikiPathways)
Electron transport chain: OXPHOS system in mitochondriaPathwayWP111 (WikiPathways)
FerroptosisPathwayWP4313 (WikiPathways)
Inflammatory response pathwayPathwayWP453 (WikiPathways)
KE1115: Increased, Reactive oygen speciesEvent1115 (AOP-Wiki KE)
KE1194: Increase, DNA DamageEvent1194 (AOP-Wiki KE)
KE1262: ApoptosisEvent1262 (AOP-Wiki KE)
KE1496: Increased, secretion of proinflammatory mediatorsEvent1496 (AOP-Wiki KE)
KE1633: Increase in inflammationEvent1633 (AOP-Wiki KE)
KE1815: Activation of ER stressEvent1815 (AOP-Wiki KE)
KE1848: Toll Like Receptor (TLR) DysregulationEvent1848 (AOP-Wiki KE)
KE1923: Altered gene expression, P53 dependent apoptosis pathwayEvent1923 (AOP-Wiki KE)
KE1968: Increase, Mitochondrial DysfunctionEvent1968 (AOP-Wiki KE)
KE55: Cell injury/deathEvent55 (AOP-Wiki KE)
KE814: Occurence, Kidney ToxicityEvent814 (AOP-Wiki KE)
Overview of proinflammatory and profibrotic mediatorsPathwayWP5095 (WikiPathways)
Oxidative damage responsePathwayWP3941 (WikiPathways)
Oxidative stress responsePathwayWP408 (WikiPathways)
RIPK1-mediated regulated necrosisPathwayWP5022 (WikiPathways)
SLC22A2GeneProductENSG00000112499 (Ensembl)
SLC31A1GeneProductENSG00000136868 (Ensembl)
TLR4 signaling and tolerancePathwayWP3851 (WikiPathways)
Toll-like receptor signaling pathwayPathwayWP75 (WikiPathways)
Unfolded protein responsePathwayWP4925 (WikiPathways)
p53 transcriptional gene networkPathwayWP4963 (WikiPathways)

Annotated Interactions

No annotated interactions

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