mRNA vaccine activation of dendritic cell and induction of IFN-1 (Homo sapiens)

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1111111111CD4+ T cellDendritic cellEndosomemRNA vaccineNucleusCD8+ T cellLipid coatMAVSHumoral immunityTLR3Cellular immunityMDA5Spike ProteinSARS-CoV 2 mRNAS peptide presentationProinflammatory cytokine genesIFN-1 receptorProinflammatory cytokinesIRF-7RIG-I (DDX58)ISREIRF3Type 1 IFNsT cell receptorNF-kBSARS-CoV 2 mRNATLR7TLR8SARS-CoV 2 mRNAType 1 IFNsS peptide presentationT cell receptorIFN-1 receptorType 1 IFNs


Description

After uptake, mRNA is translated into spike protein and presented as cell-surface MHC-bound peptides to CD4+ and CD8+ T cells. Cytosolic sensing of RNA by RIG-I and MDA5 plus TLR binding within endosomes leads to activation of IFN regulatory factor 3/7 (IRF3/7) and nuclear factor κB (NF-κB), which bind to DNA inducing gene transcription, and production of IFN-I and proinflammatory cytokines, respectively

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Bibliography

  1. Sprent J, King C; ''COVID-19 vaccine side effects: The positives about feeling bad.''; Sci Immunol, 2021 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
122433view11:35, 5 April 2022EweitzModified title
121329view09:44, 15 February 2022NhungPIncrease node label size
121328view09:40, 15 February 2022NhungPNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Cellular immunity
Humoral immunity
IFN-1 receptorProtein
IRF-7ProteinQ92985 (Uniprot-TrEMBL)
IRF3ProteinQ14653 (Uniprot-TrEMBL)
ISRE
MAVSProteinQ7Z434 (Uniprot-TrEMBL)
MDA5ProteinQ9BYX4 (Uniprot-TrEMBL)
NF-kBProteinQ9Y6Q6 (Uniprot-TrEMBL)
Proinflammatory cytokine genes
Proinflammatory cytokinesGeneProduct
RIG-I (DDX58)ProteinO95786 (Uniprot-TrEMBL)
S peptide presentationProteinQ95460 (Uniprot-TrEMBL)
SARS-CoV 2 mRNARna
Spike ProteinProteinP0DTC2 (Uniprot-TrEMBL)
T cell receptorProteinP01848 (Uniprot-TrEMBL)
TLR3ProteinO15455 (Uniprot-TrEMBL)
TLR7ProteinQ9NYK1 (Uniprot-TrEMBL)
TLR8ProteinQ9NR97 (Uniprot-TrEMBL)
Type 1 IFNsGeneProduct

Annotated Interactions

No annotated interactions

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