Hypertrophy model (Homo sapiens)

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1-634ExtracellularNucleus+296correlate to all 4 MINOR probesHB-EGF correlatedangiogenesis+500-698+1protein synthesisproliferative responseWDR1ANKRD1TCF8IFNGEIF4EBP1IL18MYOGVEGFCYR61ADAM10EIF4E?IFRD1JUNDATF3IL1ANR4A3DUSP14GDF8IL1R1MINORHBEGF


Model of the effects of resistance exercise on gene regulation in human quadriceps muscle after an acute bout of isotonic exercise.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms



  1. Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, Takahashi JS, Schambelan M, Conklin BR; ''Time- and exercise-dependent gene regulation in human skeletal muscle.''; Genome Biol, 2003 PubMed Europe PMC Scholia


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117755view12:52, 22 May 2021EweitzModified title
106595view19:34, 10 September 2019KhanspersModified description
105619view04:58, 10 August 2019KhanspersModified description
97838view06:54, 10 June 2018EgonwOntology Term : 'muscle cell' added !
97669view08:05, 1 June 2018AMTanOntology Term : 'cardiac muscle cell' added !
94803view23:50, 5 October 2017AlexanderPicoModified description
94802view23:47, 5 October 2017AlexanderPicoConverted lines, compacted layout
88898view07:57, 17 August 2016MirellaKalafatiOntology Term : 'disease pathway' added !
88647view15:07, 12 August 2016JmeliusOntology Term : 'hypertrophic cardiomyopathy pathway' added !
71358view18:35, 17 October 2013MaintBotAutomated update of data sources
62377view01:09, 28 April 2013AlexanderPicoCleaned up groups and layout
45364view20:54, 7 October 2011AlexanderPicoOntology Term : 'heart disease' added !
41035view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
38912view20:49, 24 September 2010KhanspersChanged cellular compartments
38905view20:40, 24 September 2010Khanspers
32131view13:55, 14 August 2009MaintBotFixed group labels
21764view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Hypertrophy model]] moved to [[Pathway:WP516]]: Moved to stable identifier
13983view14:04, 20 May 2008Thomastransfered literature from comment
13981view14:01, 20 May 2008Thomasconnected lines
10982view14:00, 29 February 2008Derobcosmetic change
8146view13:46, 7 January 2008MaintBot[[Pathway:Human:Hypertrophy model]] moved to [[Pathway:Homo sapiens:Hypertrophy model]]: Renaming species
7693view16:10, 18 December 2007MaintBotfixed category names
7473view12:42, 4 November 2007MaintBotAdded categories to GPML
6333view22:17, 22 May 2007A.C.Zambongpml file for [[Human:Hypertrophy_model]]

External references


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NameTypeDatabase referenceComment
ADAM10GeneProduct102 (Entrez Gene)
ANKRD1GeneProduct27063 (Entrez Gene)
ATF3GeneProduct467 (Entrez Gene)
CYR61GeneProduct3491 (Entrez Gene)
DUSP14GeneProduct11072 (Entrez Gene)
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
GDF8GeneProduct2660 (Entrez Gene)
HBEGFGeneProduct1839 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IFRD1GeneProduct3475 (Entrez Gene)
IL18GeneProduct3606 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1R1GeneProduct3554 (Entrez Gene)
JUNDGeneProduct3727 (Entrez Gene)
MYOGGeneProduct4656 (Entrez Gene)
NR4A3GeneProduct8013 (Entrez Gene)
TCF8GeneProduct6935 (Entrez Gene)
VEGFGeneProduct7422 (Entrez Gene)
WDR1GeneProduct9948 (Entrez Gene)

Annotated Interactions

No annotated interactions

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