SARS-CoV-2 replication organelle formation (Homo sapiens)

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11111Double membrane vesiclesfor viral replicationClass III PI3K complexERBeclin-1VPS15 VPS34AMBRAATG14PI3PDFCP1nsp3ERrep 1abrep 1abrep 1abrep 1abrep 1ab


Components of the class III PI3K complex is speculated to promote SARS-CoV-2 replication. PI3P and DFCP1 contribute to the formation of double membrane vesicles needed for viral replication. Nsp3 protein from SARS-CoV 2 stimulates the accumulation of PI3P.

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Ontology Terms



  1. Twu WI, Lee JY, Kim H, Prasad V, Cerikan B, Haselmann U, Tabata K, Bartenschlager R; ''Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation.''; Cell Rep, 2021 PubMed Europe PMC Scholia


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120744view13:37, 28 December 2021EgonwMarked a data node with a ChEBI identifier as "Metabolite"
120687view12:29, 23 December 2021EweitzOntology Term : 'COVID-19' added !
120681view08:44, 23 December 2021NhungPCorrect description
120680view08:40, 23 December 2021NhungPcorrect title
120679view08:38, 23 December 2021NhungPNew pathway

External references


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NameTypeDatabase referenceComment
AMBRAProteinQ9C0C7 (Uniprot-TrEMBL)
ATG14ProteinQ6ZNE5 (Uniprot-TrEMBL)
Beclin-1ProteinQ14457 (Uniprot-TrEMBL)
DFCP1ProteinQ9HBF4 (Uniprot-TrEMBL)
PI3PMetabolite26034 (ChEBI)
VPS15 ProteinQ99570 (Uniprot-TrEMBL)
VPS34ProteinQ8NEB9 (Uniprot-TrEMBL)
nsp3ProteinYP_009725299 (NCBI Protein)
rep 1abProteinP0DTD1 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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