Lung pathology of COVID-19 (Homo sapiens)

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1111111111TLR7IFIH1TBK1IL18CCL2Airway epithelial cellSTING1IL1BIL6CGASCXCL10CXCL11CXCL8IRF3IFN-ICell deathTLR3IFN-IIDDX58TLR8MAVSTNFNFKB1CSF2CXCL9IRF3NFKB1NucleusSARS-CoV-2Increased in serum andbronchoalveolar lavage fluid


Description

Beginning of a pathway on the Lung Pathology of COVID-19 based on a figure in a paper (Reference 1)

Comments

 
This pathway is based on figure 4 of Ref 1

Quality Tags

Ontology Terms

 

Bibliography

  1. Harrison AG, Lin T, Wang P; ''Mechanisms of SARS-CoV-2 Transmission and Pathogenesis.''; Trends Immunol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120619view23:32, 18 December 2021EweitzLabel group of genes
120618view17:59, 18 December 2021EweitzRemove "Golgi" label due to WP-PathVisio graphics issue
120617view17:57, 18 December 2021EweitzFix WP-PathVisio graphics issue; label organelles, virus
120616view13:08, 18 December 2021EweitzUse official gene symbol, STING1
120615view13:04, 18 December 2021EweitzTighten graphics, refine datanodes, case
120379view23:48, 29 November 2021EweitzOntology Term : 'COVID-19' added !
120378view23:47, 29 November 2021EweitzModified title
120328view16:04, 26 November 2021XNautsNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Airway epithelial cell
CCL2GeneProductENSG00000108691 (Ensembl)
CGASGeneProductENSG00000164430 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL11GeneProductENSG00000169248 (Ensembl)
CXCL8MetaboliteCHEBI:138181 (ChEBI)
CXCL9GeneProductENSG00000138755 (Ensembl)
Cell death
DDX58GeneProductENSG00000107201 (Ensembl)
IFIH1GeneProductENSG00000115267 (Ensembl)
IFN-II PF00714 (Pfam)
IFN-IPF00143 (Pfam)
IL18GeneProductENSG00000150782 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
Increased in serum and bronchoalveolar lavage fluid
MAVSGeneProductENSG00000088888 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
Nucleus
SARS-CoV-2
STING1GeneProductENSG00000184584 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TLR3GeneProductENSG00000164342 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)

Annotated Interactions

No annotated interactions
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