Catecholamine synthesis (Rattus norvegicus)

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4AdoMetNoradrenaline4a-hydroxy-tetrahydrobiopterinO2AscorbateDopaminetetrahydrobiopterinH2ODbhtetrahydrobiopterinPah4a-hydroxy-tetrahydrobiopterinO2DehydroascorbateAdrenalineO2L-DOPAAdoHcyPnmtCO2DdcL-tyrosineThPhenylalanine5, 14, 213, 9, 11, 18, 22232, 6, 7, 12, 254, 10, 13, 19


Description

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Ontology Terms

 

Bibliography

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  1. Pigeon D, Drissi-Daoudi R, Gros F, Thibault J; ''[Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase]''; C R Acad Sci III, 1986 PubMed Europe PMC
  2. LOVENBERG W, WEISSBACH H, UDENFRIEND S; ''Aromatic L-amino acid decarboxylase.''; J Biol Chem, 1962 PubMed Europe PMC
  3. Kaufman S; ''The enzymatic conversion of phenylalanine to tyrosine''; J. Biol. Chem, 1956
  4. Ikeda M, Levitt M, Udenfriend S; ''Phenylalanine as substrate and inhibitor of tyrosine hydroxylase.''; Arch Biochem Biophys, 1967 PubMed Europe PMC
  5. Levin Eprham Y., Kaufman S; ''Studies on the enzyme catalyzing the conversion of 3,4-Dihydroxyphenylethylamine to Norepinhephrine''; j.biolchemistry, 1961
  6. McGilvery, R.W., Cohen, P.P.; ''The decarboxylation of L-phenylalanine by Streptococcus faecalis R.''; J. Biol. Chem. 174, 1948
  7. Christenson JG, Dairman W, Udenfriend S; ''On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).''; Proc Natl Acad Sci U S A, 1972 PubMed Europe PMC
  8. Sekeris, C.E.; ''Zur Tyrosinstoffwechsel der Insekten. XII. Reinigung, Eigenschaften und Substratspezifit√�ƒƒ√ɬ�‚√Ǭ�t der DOPA-Decarboxylase Hoppe-Seyler's Z.''; Physiol. Chem. 332, 1963
  9. Udenfriend, S, Cooper, J.R; ''The enzymic conversion of phenylalanine to tyrosine''; J. Biol. Chem, 1952
  10. Goodwill KE, Sabatier C, Marks C, Raag R, Fitzpatrick PF, Stevens RC; ''Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases.''; Nat Struct Biol, 1997 PubMed Europe PMC
  11. Carr RT, Balasubramanian S, Hawkins PC, Benkovic SJ; ''Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase.''; Biochemistry, 1995 PubMed Europe PMC
  12. Sekeris, C.E.; ''Zur Tyrosinstoffwechsel der Insekten. XII. Reinigung, Eigenschaften und Substratspezifit√�ƒ√�€t der DOPA-Decarboxylase Hoppe-Seyler's Z.''; Physiol. Chem. 332, 1963
  13. El Mestikawy S, Glowinski J, Hamon M; ''Tyrosine hydroxylase activation in depolarized dopaminergic terminals--involvement of Ca2+-dependent phosphorylation.''; Nature, 1983 PubMed Europe PMC
  14. Levin, E.Y., Levenberg, B., Kaufman, S.; ''''; ,
  15. Levin, E.Y., Levenberg, B., Kaufmann, S.; ''The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine.''; J. Biol. Chem. 235, 1960
  16. Connett RJ, Kirshner N; ''Purification and properties of bovine phenylethanolamine N-methyltransferase.''; J Biol Chem, 1970 PubMed Europe PMC
  17. Ishida Y, Yokoyama C, Inatomi T, Yagita K, Dong X, Yan L, Yamaguchi S, Nagatsu I, Komori T, Kitahama K, Okamura H; ''Circadian rhythm of aromatic L-amino acid decarboxylase in the rat suprachiasmatic nucleus: gene expression and decarboxylating activity in clock oscillating cells.''; Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Chuo-ku, Kobe 650-0017, Japan., 2002 PubMed Europe PMC
  18. Kaufman S; ''Studies on the mechanism of the enzymic conversion of phenylalanine to tyrosine''; J. Biol. Chem, 1959
  19. Nagatsu, T., Levitt, M., Udenfriend, S; ''Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis.''; J. Biol. Chem. 239, 1964
  20. Nagatsu, T., Levitt, M., Udenfriend, S.; ''Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis.''; J. Biol. Chem. 239, 1964
  21. Friedman S, Kaufman S; ''3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity.''; J Biol Chem, 1965 PubMed Europe PMC
  22. Guroff G, Rhoads CA; ''Phenylalanine hydroxylation by Pseudomonas species (ATCC 11299a). Nature of the cofactor.''; J Biol Chem, 1969 PubMed Europe PMC
  23. Axelrod, J.; ''Purification and properties of phenylethanolamine-N-methyl transferase.''; J. Biol. Chem. 237, 1962
  24. Axelrod, J.; ''Purification and properties of phenylethanolamine-N-methyl transferase.''; J.Biol.Chem, 1962
  25. WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S; ''Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation.''; J Biol Chem, 1957 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106998view13:45, 17 September 2019MaintBotHMDB identifier normalization
102580view07:54, 10 January 2019EgonwMinor typo fix
70129view20:13, 12 July 2013MaintBotupdated to 2013 schema
67100view10:06, 26 June 2013Christine ChichesterOntology Term : 'catecholamine biosynthetic pathway' added !
48277view23:27, 17 May 2012KhanspersUpdating PubChem xrefs
48266view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41663view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
21758view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Catecholamine synthesis]] moved to [[Pathway:WP513]]: Moved to stable identifier
13944view03:59, 20 May 2008AlexanderPicocurved connectors
13942view03:57, 20 May 2008AlexanderPicoPeriodical save, work in progress
13939view03:46, 20 May 2008AlexanderPicoPeriodical save, work in progress
11467view12:28, 1 April 2008ThomasModified description
11466view12:14, 1 April 2008Thomasfixed anchor links + cosmetic changes
11461view11:02, 1 April 2008Thomasremoved obsolete literature reference
11460view10:58, 1 April 2008Thomas
11455view07:26, 1 April 2008NoortjevdvorstPeriodical save, work in progress
11424view17:40, 27 March 2008Thomas
11416view13:36, 27 March 2008Annemichielsenrecensies
11224view10:46, 25 March 2008Thomas
11223view10:13, 25 March 2008Annemichielsenreference added
11222view10:05, 25 March 2008Annemichielsennew
11221view10:01, 25 March 2008AnnemichielsenPeriodical save, work in progress
11220view09:51, 25 March 2008AnnemichielsenPeriodical save, work in progress
11213view06:35, 25 March 2008ThomasModified categories
11212view06:35, 25 March 2008Thomasrestored pathway
11208view14:56, 24 March 2008AnnemichielsenPeriodical save, work in progress
11207view14:46, 24 March 2008AnnemichielsenPeriodical save, work in progress
11206view14:36, 24 March 2008AnnemichielsenPeriodical save, work in progress
11205view14:26, 24 March 2008AnnemichielsenPeriodical save, work in progress
11203view14:16, 24 March 2008AnnemichielsenPeriodical save, work in progress
11202view13:55, 24 March 2008AnnemichielsenPeriodical save, work in progress
11201view13:38, 24 March 2008AnnemichielsenPeriodical save, work in progress
11198view13:27, 24 March 2008AnnemichielsenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
4a-hydroxy-tetrahydrobiopterinMetabolite23724532 (PubChem-compound)
AdoHcyMetaboliteHMDB0000939 (HMDB)
AdoMetMetabolite90473 (PubChem-compound)
AdrenalineMetaboliteHMDB0000068 (HMDB)
AscorbateMetaboliteHMDB0000044 (HMDB)
CO2Metabolite
DbhGeneProduct25699 (Entrez Gene)
DdcGeneProduct24311 (Entrez Gene)
DehydroascorbateMetaboliteHMDB0001264 (HMDB)
DopamineMetaboliteHMDB0000073 (HMDB)
H2OMetabolite
L-DOPAMetaboliteHMDB0000609 (HMDB)
L-tyrosineMetaboliteHMDB0000158 (HMDB)
NoradrenalineMetaboliteHMDB0000216 (HMDB)
O2Metabolite
PahGeneProduct24616 (Entrez Gene)
PhenylalanineMetaboliteHMDB0000159 (HMDB)
PnmtGeneProduct24661 (Entrez Gene)
ThGeneProduct25085 (Entrez Gene)
tetrahydrobiopterinMetaboliteHMDB0000027 (HMDB)

Annotated Interactions

No annotated interactions

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