Alzheimer's disease (Homo sapiens)

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IRS2ATG14NeuronER1, 4, 5, 8, 10...23383821Anterograde cargoMicrogliaLegendMicrotubuleFragmentationAntioxidant responsesAmino acid metabolismAmyloid BetaAPP Intracellular domainKinesin 1Impaired neuronal insulin signalingGene mutated in Alzheimer'sMitochondrial dysfunctionNeurofibrillary tanglesNonamyloidogenic APP processingInsulin resistanceMitochondiral dysfunctionDecreased AB clearanceImpairement of autophagyPI3K complexULK complexATP depletionNeuronal InjuryReduction in LTPCalcium overloadER chaperonesMPTPCell deathDecreased energy production?Oligomeric Amyloid BetaDefective insulin signalingNAC fragmentRAGEFe2+Protein oxidationAPP intracellular domainWnt signaling pathwayIP3ApoptosisInduction of ApoptosisCa2+Modulation of gene expressionP3 peptidep50 ATF6NObeta-amyloid protein 40TNFRSF1ACalcium Signaling PathwayAPPPI3PMAPTHydrogen peroxideNAE1Cu+RTN3Oxidative PhosphorylationAGEssuperoxide6APBB1GAPDHADAM10BACE1PSENENPSEN1NCSTNAPH1AIDEMMELPLAPOELRP1FASTNFRSF1AFADDCASP8Cx ICx IICx IIICx IVCx VAPP processingHSD17B10Fall in mitochondrialmembrane potentialIncreased ROSDegredationBIDCYCSCALM1BADCALM2PCALM3CALML3CALML5PPP3CAPPP3CBPPP3CCPPP3R1PPP3R2ADAM17PSEN2APAF1CASP9CASP3AB AggregationSNCASenile plaqueGPCRGRIN1CACNA1CGRIN2AGRIN2BGRIN2CGRIN2DCACNA1DCACNA1FCACNA1SGNAQPLCB1PLCB2PLCB3PLCB4Aggr. amyloidTNFIL1BMAPK1MAPK3CASP12ApoptosisRYR3ATP2A2ATP2A1ATP2A3EIF2AK3ERN1ATF6ITPR1ITPR2ITPR3Ca2+Ca2+ER stressCAPN1CAPN2CDK5R1 / p35CDK5R1 / p25NOS1CDK5MAPTPCASP3CASP7Paired helical filamentsNeurofibrillarytanglesApoptosisDNA damageInflammationLipid peroxidationONOO-RTN4HyperinsulinemiaSequestration of IDEConcentrated intoendosome/lysosomeINSINSRIRS1PPPIRS4PPIDMCUCa2+Ca2+Ca2+beta-amyloid protein 42beta-amyloid protein 40beta-amyloid protein 42AKT1AKT2AKT3PIK3CAPIK3R1PIK3R2PIK3CBPIK3CDPIK3R3PIP3EIF2AK2MAPK8MAPK9MAPK10GPR83CHUKIKBKBSynaptic dysfunctionImpaired memoryCHRNA7CYBBNOX1NOX4NFKB1RELA(Tau-p)nNRASKRASHRASRAF1ARAFBRAFNOS2TNFIL1AIL1BPTGS2IL6CSF1DKK119DKK2DKK4MTORULK2ULK1PATG13PATG101RB1CC1BECN1BECN2PPIK3R4NRBF2PIK3C3AMBRA1PATG2AATG2BWIPI1WIPI2PSEN1GSK3Bbeta-amyloid protein 40beta-amyloid protein 42Ca2+Ca2+KLC3KIF5AKIF5BKIF5CKLC1KLC2KLC4PTUBA1BTUBA3ETUBA3DTUBA8TUBA4ATUBA3CTUBA1ATUBAL3TUBA1CTUBB3TUBB4ATUBB4BTUBBTUBB8TUBB2BTUBB2ATUBB1TUBB6Axonal transport defectsWntWNT3AWNT7AWNT11WNT1WNT5BWNT2WNT2BWNT6WNT5AWNT16WNT4WNT3WNT10BWNT7BWNT10AWNT16FZD3FZD8LRP5FZD10FZD7FZD4FZD1LRP6FZD6FZD5FZD9FZD2DVL3FRAT1CSNK1EDVL2DVL1FRAT2TPTEP2-CSNK1EGSK3BCSNK2BCSNK2A1CSNK2A3CSNK2A2APCCSNK1A1AXIN1CSNK1A1LAXIN2APC2CSNK1A1CSNK1A1LCTNNB1PPPPPP3CAPPP3CBPPP3CCPPP3R1PPP3R2GSK3BsAPP alphaAPP-C83APP-C99sAPP betaEIF2S1ATF4DDIT3TRAF2MAP3K5MAP2K7MAPK8PPMAPK10MAPK9PXBP1PPPER chaperonesERADDDIT3XBP1Proteasome 20SCatalytic Core (p45)PSMA2PSMB1PSMA5PSMB4PSMB2PSMA3PSMA7PSMA1PSMB6PSMA6PSMB5PSMA4PSMB7PSMB3PSMA819S regulatorPSMD8SEM1PSMD1PSMC6PSMC5PSMC4PSMC3PSMC2PSMC1PSMD7PSMD6ADRM1PSMD4PSMD3PSMD2PSMD14PSMD13PSMD12PSMD9PPIFSLC25A4SLC25A5SLC25A6VDAC1VDAC2VDAC3SLC25A31CALML4CALML6APH1BAmyloidogenic APP processingbeta-amyloid protein 40beta-amyloid protein 42Oligomeric Intracellular ABCa2+MAP2K1PPMAP2K2PPMAPK1PPMAPK3PPbeta-amyloid protein 40beta-amyloid protein 42PSEN1PSEN2


Description

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information.

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Ontology Terms

 

Bibliography

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History

CompareRevisionActionTimeUserComment
119432view00:38, 29 June 2021Khanspersadded literature references
119431view23:52, 28 June 2021KhanspersModified description
119430view23:51, 28 June 2021KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10GeneProductENSG00000137845 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
ADRM1GeneProductENSG00000130706 (Ensembl)
AGEsMetaboliteCHEBI:84123 (ChEBI)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
AMBRA1GeneProductENSG00000110497 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
APAF1GeneProductENSG00000120868 (Ensembl)
APBB1GeneProductENSG00000166313 (Ensembl)
APC2GeneProductENSG00000115266 (Ensembl)
APCGeneProduct324 (Entrez Gene)
APH1AGeneProductENSG00000117362 (Ensembl)
APH1BGeneProductENSG00000138613 (Ensembl)
APOEGeneProductENSG00000130203 (Ensembl)
APP intracellular domainGeneProductP05067 (Uniprot-TrEMBL)
APP processingPathway
APP-C83GeneProductP05067 (Uniprot-TrEMBL)
APP-C99GeneProductP05067 (Uniprot-TrEMBL)
APPGeneProductENSG00000142192 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
ATF4GeneProductENSG00000128272 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
ATG101GeneProductENSG00000123395 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG13GeneProductENSG00000175224 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG14GeneProductENSG00000126775 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG2AGeneProductENSG00000110046 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG2BGeneProductENSG00000066739 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATP2A1GeneProductENSG00000196296 (Ensembl)
ATP2A2GeneProductENSG00000174437 (Ensembl)
ATP2A3GeneProductENSG00000074370 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
AXIN2GeneProductENSG00000168646 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BACE1GeneProductENSG00000186318 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BECN1GeneProductENSG00000126581 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
BECN2GeneProductENSG00000196289 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
BIDGeneProductENSG00000015475 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
CACNA1CGeneProductENSG00000151067 (Ensembl)
CACNA1DGeneProductENSG00000157388 (Ensembl)
CACNA1FGeneProductENSG00000102001 (Ensembl)
CACNA1SGeneProductENSG00000081248 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CALM2GeneProductENSG00000143933 (Ensembl)
CALM3GeneProductENSG00000160014 (Ensembl)
CALML3GeneProductENSG00000178363 (Ensembl)
CALML4GeneProductENSG00000129007 (Ensembl)
CALML5GeneProductENSG00000178372 (Ensembl)
CALML6GeneProductENSG00000169885 (Ensembl)
CAPN1GeneProductENSG00000014216 (Ensembl)
CAPN2GeneProductENSG00000162909 (Ensembl)
CASP12GeneProductENSG00000204403 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
CDK5R1 / p25GeneProductENSG00000176749 (Ensembl)
CDK5R1 / p35GeneProductENSG00000176749 (Ensembl)
CHRNA7GeneProductENSG00000175344 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CYBBGeneProductENSG00000165168 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
Ca2+MetaboliteHMDB0000464 (HMDB)
Calcium Signaling PathwayPathway
Cu+MetaboliteHMDB0000657 (HMDB)
Cx IGeneProduct
Cx IIGeneProduct
Cx IIIGeneProduct
Cx IVGeneProduct
Cx VGeneProduct
DDIT3GeneProductENSG00000175197 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DKK2GeneProductENSG00000155011 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DKK4GeneProductENSG00000104371 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DNA damagePathway
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
EIF2AK3GeneProductENSG00000172071 (Ensembl)
EIF2S1GeneProductENSG00000134001 (Ensembl)
ERN1GeneProductENSG00000178607 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
Fe2+MetaboliteHMDB0000692 (HMDB)
GAPDHGeneProductENSG00000111640 (Ensembl)
GNAQGeneProductENSG00000156052 (Ensembl)
GPCRGeneProduct
GPR83GeneProductENSG00000123901 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
GSK3BGeneProductENSG00000082701 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
HRASGeneProductENSG00000174775 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
HSD17B10GeneProductENSG00000072506 (Ensembl)
Hydrogen peroxideMetaboliteHMDB0003125 (HMDB)
IDEGeneProductENSG00000119912 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
INSGeneProduct3630 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
IP3MetaboliteHMDB0001498 (HMDB)
IRS1GeneProductENSG00000169047 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
IRS4GeneProductENSG00000133124 (Ensembl)
ITPR1GeneProductENSG00000150995 (Ensembl)
ITPR2GeneProductENSG00000123104 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
Induction of ApoptosisPathwayWP1896 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
KIF5AGeneProductENSG00000155980 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KIF5BGeneProductENSG00000170759 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KIF5CGeneProductENSG00000168280 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC1GeneProductENSG00000126214 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC2GeneProductENSG00000174996 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC3GeneProductENSG00000104892 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC4GeneProductENSG00000137171 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KRASGeneProductENSG00000133703 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653
LPLGeneProductENSG00000175445 (Ensembl)
LRP1GeneProductENSG00000123384 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
Lipid peroxidationPathwayWP1878 (WikiPathways)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K7GeneProductENSG00000076984 (Ensembl)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAPTGeneProductENSG00000186868 (Ensembl)
MCUGeneProductENSG00000156026 (Ensembl)
MMEGeneProductENSG00000196549 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
Modulation of gene expressionPathwayWP1821 (WikiPathways)
NAC fragmentProteinP37840 (Uniprot-TrEMBL)
NAE1GeneProductENSG00000159593 (Ensembl)
NCSTNGeneProductENSG00000162736 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NOMetaboliteHMDB0003378 (HMDB)