Id Signaling Pathway (Mus musculus)

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PhosphorylationRecruitmentActivationProteolytic cleavageID Gene RegulationGlycosylationDDPNUEnzyme complexNucleusCytoplasmENDTranslocationAcetylationDephosphorylationProteins in a complex interactionAutophosphorylationGolgi apparatusMitochondriaMolecule in the PathwayControlMethylationPMExtracellularDDeubiquitinationLigandUbiquitinationERMolecular associationEndosomeDSumoylationPalmitoylationInhibitionGOReceptorDesumoylationPCY(Protein-protein interaction)Reaction through unknown mechanisms/moleculesPAccession Number: NetPath 5; cellmap:5DeacetylationMTECCY -> NUDemethylationEndoplasmic reticulumPlasma membraneMyf5TertAtf3Pax8Cd40lgSmad4Smad3Id2Smad5Nfkb1Elk4Bmpr2Id1Elk3PI3KRb1Myod1Id2Id4VegfaEgfCcne1RASMyf6MyogCtnnb1Smad4Irs1Psmd4Rbl2MscKdrBmp6Pax5Smad1IFI16Smad1Igf1MAPKTgif1Igf1rId3Tcf12Bmp2Pax2ERKCcna2Smad5Atf3Acvrl1TCRSrebf1Tcf7l2Elk1NgfSmad3LCKCdk2Rbl1Tcfe2aHes1Gene SymbolFlt1Rela


Description

Inhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA binding capacity. This family of proteins is comprised of IDs 1, 2, 3 and 4. They can be stimulated by ligands such as the Vascular Endothelial Growth Factor (VEGF), TGF beta and the T cell receptor. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_5

Comments

GenMAPP notes 
NetPath 5; cellmap:5 - Id Signaling Pathway

The Id Signaling Pathway was kindly reviewed by Jonathan Perk and other members of Robert Benezra’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP53(r20789) with a 87% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
69147view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67359view10:42, 26 June 2013Christine ChichesterOntology Term : 'Inhibitor of DNA binding signaling pathway' added !
41335view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35747view23:58, 12 February 2010AlexanderPico
34402view23:02, 9 December 2009MaintBotAutomatic update of empty xrefs
31468view21:19, 13 August 2009MaintBotFixed text labels
30886view00:18, 30 July 2009MaintBotConverted from Homo sapiens
21756view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Id NetPath 5]] moved to [[Pathway:WP512]]: Moved to stable identifier
8154view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Id NetPath 5]] moved to [[Pathway:Mus musculus:Id NetPath 5]]: Renaming species
7697view16:10, 18 December 2007MaintBotfixed category names
7263view12:41, 4 November 2007MaintBotAdded categories to GPML
6466view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:Id_NetPath_5]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acvrl1GeneProduct11482 (Entrez Gene)
Atf3GeneProduct11910 (Entrez Gene)
Bmp2GeneProduct12156 (Entrez Gene)
Bmp6GeneProduct12161 (Entrez Gene)
Bmpr2GeneProduct12168 (Entrez Gene)
Ccna2GeneProduct12428 (Entrez Gene)
Ccne1GeneProduct12447 (Entrez Gene)
Cd40lgGeneProduct21947 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
ERKGeneProduct
EgfGeneProduct13645 (Entrez Gene)
Elk1GeneProduct13712 (Entrez Gene)
Elk3GeneProduct13713 (Entrez Gene)
Elk4GeneProduct13714 (Entrez Gene)
Flt1GeneProduct14254 (Entrez Gene)
Gene SymbolGeneProduct
Hes1GeneProduct15205 (Entrez Gene)
IFI16GeneProduct
Id1GeneProduct15901 (Entrez Gene)
Id2GeneProduct15902 (Entrez Gene)
Id3GeneProduct15903 (Entrez Gene)
Id4GeneProduct15904 (Entrez Gene)
Igf1GeneProduct16000 (Entrez Gene)
Igf1rGeneProduct16001 (Entrez Gene)
Irs1GeneProduct16367 (Entrez Gene)
KdrGeneProduct16542 (Entrez Gene)
LCKGeneProduct16818 (Entrez Gene)
MAPKGeneProduct
MscGeneProduct17681 (Entrez Gene)
Myf5GeneProduct17877 (Entrez Gene)
Myf6GeneProduct17878 (Entrez Gene)
Myod1GeneProduct17927 (Entrez Gene)
MyogGeneProduct17928 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
NgfGeneProduct18049 (Entrez Gene)
PI3KGeneProduct
Pax2GeneProduct18504 (Entrez Gene)
Pax5GeneProduct18507 (Entrez Gene)
Pax8GeneProduct18510 (Entrez Gene)
Psmd4GeneProduct19185 (Entrez Gene)
RASGeneProduct19412 (Entrez Gene)
Rb1GeneProduct19645 (Entrez Gene)
Rbl1GeneProduct19650 (Entrez Gene)
Rbl2GeneProduct19651 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
Smad1GeneProduct17125 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
Smad4GeneProduct17128 (Entrez Gene)
Smad5GeneProduct17129 (Entrez Gene)
Srebf1GeneProduct20787 (Entrez Gene)
TCRGeneProduct
Tcf12GeneProduct21406 (Entrez Gene)
Tcf7l2GeneProduct21416 (Entrez Gene)
Tcfe2aGeneProduct21423 (Entrez Gene)
TertGeneProduct21752 (Entrez Gene)
Tgif1GeneProduct21815 (Entrez Gene)
VegfaGeneProduct22339 (Entrez Gene)

Annotated Interactions

No annotated interactions
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