Network map of SARS-CoV-2 signaling pathway (Homo sapiens)

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133123201019132195165 Viral entry into cellsCytochrome CSARS-CoV-2SACE21, 11, 22K625K702TMPRSS24SARS-CoV-2OS9MARK2TBKBP1CLCC1FAM98ASIGMAR1ERLEC1TLE1SDF2GTF2F2UGGT2NEK9G3BP2NPTX1ATP6AP1 TLE3ATP13A3MOV10UPF1TLE5ADAM9G3BP1MIB1SRP72SRP54SRP19ATE1GGHLARP1MDN1TOMM70TRIM59NSP618, 22ORF7bORF3a5, 18, 225, 18NSP10M18, 22S18, 22NSP218, 22ORF66, 18, 22NSP918, 22N5, 18, 225, 18, 22ORF9bNSP1318, 2218, 22NSP818, 22ORF7aORF818, 2218, 22RTN4PITRM1COQ8BPMPCBINTS4CASP37BIDCASP814CASP9BID7ApoptosisSTAT18, 15S727JAK2MYD88IRAK122TRAF62TLRsNFKB222S222TGFBR222SMAD5S465SMAD1S463FGBSERPINE1FGGITGA3COL7A1FN1MAPK8Y185T18322FOSEGR1PTGS2JUNDUSP1ITCHMAVS2S222TANK22S12922TRAF2K165K27CXCL2TNFIL6TRAF3IRF3ISG56ISREInterferon signalingMX1IFIT1IRF9IFN1IFNB115MAPK1T185Y18722MAPK3T202Y204PLA2G4AThromboxaneproduction20MAPK14T18022Y182IFI27BST2IFI6IFITM1FOSJUNDUSP1IRF27JUNBIFITM3IFI27Interferon-MAPK pathwaymediated adaptive immune responseIFIH1IFNB115ACE2CXCL8 CCL11IL6CXCL9CCR5CXCR1CXCR2TNFIL1RACCL20IL6CXCL6CD226CCR6CXCL16CXCL9CXCL1IL1ACXCL2CD163CXCL16CXCR7CXCL3CXCL2IL1BCCL8CXCL5CXCL8CCL2Uncontrolled infiltration and activation of neutrophilsIL8NKRFIL65SQSTM1K435 S36122K281S272T269S355K157MAP1LC3B22TAX1BP1NBR12222Autophagy receptorsGABARAPL2K46K74K2422K97K82HOPS complexVPS16VPS11VPS41VPS18VPS36VPS33AAutophagosome and lysosome fusionRPS6KB1S240K143K149S238MLST8DEPTORRPTORRHEB22LARP122ATG13ULK1S479S63822AKT1S473TSC2S1347EIF4ES209PI3KHIF1A21PRAS40EIF4EBP121AutophagyMTORS2448Autophagosome/Late endosomeNeutrophilactivationMHC class II moleculesImmunoglobulin subunitsT cell receptor(TCR) subunitsTCR signaling kinases T cell surface moleculesTNFCCL8STEAP3PIAS1IL17AFGASELPIFITM3GTSE1MIP1AIL6IL6HSPA8CFPFGBJAK1GMCSFIFI27LCKCCL27IL1AC8ACCL26CAMK4SAA1RPS6IL2RCCL5IGFBP3CCL1TP53I3CRPEIF4A2ITIH4GCSFWDR74CCL4BIRC5AHRTNFSF10IL18CXCL12MIP1BIL22MCP1HRGGSNTROCCL4ACTBCCL21PF4IFNGAPOHIL1BCTSDHBBIL2BPDGFCXCL9HPIL1RAOAS2IL8LRG1C1SAPOMCXCL10FGF2APOA2ACTG1SKAP1C1QBPCTSDCPN1APOA1IL33APOL1DDIT4BTN3A1CARD11IL1R2NFATC3IL5CEBPBPARP2 CCL3CTSZCXCL10CCNB2JUNBFAM83ACXCL13IL10APOC1LCKC1RCASP5CCL2CALC1FGGA1BGFYNIL7CTSBRAC1CFHIL13ITIH3HBDTNFCD14SERPINA10PTPN6LGALS3BPMAPK8IL1BCXCL10CFICDK1CCL22LDHCRPLBPIL16VEGFACCL15PRKCQRRASTNFSAA2IL10IFNAIL9IL18RAPCCL2IL23TFIL21CFBCCL3IL4RRM2CCL2APODCTSBIGLC2APOA1IL1AIGHEHLA-DRASERPINA5CD4CD8AIL10HLA-DRB1ALBIGLL1PRG3CD8ACRPTPOMMP25NLRP3JUNBIFI6IFI44LCCNB1LBP9HLA-DRB4IGHG4GP1BANTRK1IGHG29CTSLCD29CTSL9NLRP1HLA-DRB5IL1BIGHG1CD247CD3GLCKCD3EZAP70TRBC1FYNTRACLung injuryIn PlasmaSevere/critical patientsInflammasome activation and activity InterferonresponseIn Bronchoalveolar lavage fluid (BALF)AutophagyIn Peripheral blood mononuclear cells (PBMC)ApoptosisP53 pathwaySerumIn Peripheral blood mononuclear cells (PBMC)Common protein-protein interactions identified commonly bytwo or three studies (Stukalov et al, Gordon DE et al and Li et al)Mediated Negative regulation of gene/protein expression Positive regulation of gene/protein expression Phospho (S/T) siteLegend Autophagy receptors Ubiqutination (K) siteSARS-CoV-2 InhibitionThrough ACE2 activationNSP6ORF3aMORF7bNSP10ORF6NSP2SElevated expression ofcytokines and chemokinesCell invasion, migration, proliferation and innate immunityCommon protein-protein interactions identified commonly bytwo or three studies (Stukalov et al, Gordon DE et al and Li et al)TBK1DDX58IKBKGK285 truncatedSARS-CoV-2 protein and host protein intereactionRAP1GDS1MediatedMediatedMediatedMediatedMediatedMediatedIFNB1 MediatedProteinmRNAIn patientsin ICU TNFAGTIFNAIL17ACXCL5LDHCRPMCP1CXCL10CXCL1IL1BIL10LDHIL1AIL12ACRPIL6ALB