CCL18 signaling pathway (Homo sapiens)

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ASAP3AcK311EZRAcK263AcK60AcK258AcK253Protein1, 2PTMLactateproductionin PC3 cellsProliferation and differentiation in Tu686, 6-10Band FaDu cellsNegative regulation of hsa-miR-199a-5p leading to the increased expression of FZD4(towards Wnt/beta-catenin signaling) CCL18 Signaling PathwayLigandProliferation,migration, invasion andEMT in HSC6 and CAL27 cellsDirectionalmigration ofMDA-MB-231cellsProliferation, andmetastasis of HSC6oral carcinoma cellsProliferationof HSC6 andCAL27 cellsMyofibroblastdifferentiation ofbreast phyllodestumorsSecretion from monocytes/macrophagesthat support hematopoiesisSwitching ofCD4+CD45RO+CD25-T cells intoCD4+CD25+Foxp3+regulatoryT cellsDissociationInvasion in HEEC,ECA109,KYSE30, KYSE140KYSE510, andTE-1 cellsTumor-associatedmacrophage-inducedmetastasis ofMDA-MB-231 cellsMigration & invasionof SMMC-7721 cellsIn OS-RC-2and ACHNcells Abrogates chemotactic responses induced by their ligandsInvasion and migrationof MGC-803, GES-1 andMKN28 cellsEMT inIshikawacellsMigration andtube formationin HUVECsEMT inMDA-MB-231and MCF-7cellsMigration and invasion of BxPC-3 and PANC-1 cellsEnhancesECM adherenceof MDA-MB-231cellsAdhesion andF-actinpolymerizationMigration ofMDA-MB-231 andSKBR3 cellsPolymerizationof F-actin andCytoskeletonreorganizationin A549 and H1299 cellsMigration and invasion ofPANC-1 and Capan-2 cellsMaintenance of the Warburg effectEndothelial-MesenchymalTransformation (EndMT)in HUVECsInduction ofEMT and stemnessin Tu686 andFaDu cellsEMT in HSC6and CAL33 cellsMigration ofCaOV3 andOVCAR3 cellsMigration andinvasion of5637 bladdercancer cellsProliferation,invasion andiigration ofSkov3 cellsModulation ofCXCR4 activityNuclearGi-alphadependentMotility ofMDA-MB-231cellsEMT and invasionof MDA-MB-231and MCF-7 cellslnc-DENND3-2FZD4Ca++CCR6GSK3BS9PLCG1PPIP2PITPNM3Phsa-miR-199a-5pCCR8VIMCDH5CDH1MAPK3Y2043T202CHUKS180S176MAPK1Y187T185HOTAIRSTAT3Y705AKT1T308S473CDH2FN1PRKCZPITPKBPTK2BY402SRCY419PTK2Y397ITGA5ITGB1T788T789ANXA2Y24FN1GPER1VCAM1VCAM1RELAS536RELAS536ZEB2JAK2Y1008Y1007CDH1CDH2VIMFN1EMT in Tu686,6-10B and FaDu cellsMTDHMetastasis andEMT in Tu686,6-10B andFaDu cellsNFKBIAS32VEGFCCDH1MMP2Proliferation and migrationof MG63 and 143Bosteosarcoma cellsFAM74A4lnc-FLNA-1TCRBTTLL3HIPK1-AS1lnc-MACC1-1MTERF4UCA1lnc-SLC35A5-1LINC02245lnc-COL5A1-3ATE1-AS1GOLGA6L17PLINC01881lnc-ASAP2-5TFAP2AATF3STAT1EP300TEAD4EP300LINC00319LINC01357lnc-GOLGA8Q-1MYOSLID-AS1MIAT lnc-U2AF2-2lnc-PYGL-1lnc-RGMA-3LINC00649ATP6VOE2-AS1lnc-FANCM-1VASH1-AS1lnc-SSU72P8-2lnc-ESRRB-1lnc-SLC16A3-3LINC00266-3LINC01089RAD51-AS1LINC02582LINC00467ECI2-DTlnc-ZBTB20-1LINC00629LINC01770lnc-ZFP37-1LINC01361PPM1K-DTlnc-SCN8A-1PRKAR1B-AS1LINC00974lnc-PMAIP1-9POT1-AS1BCYRN1Collagenproductionin pulmonaryfibroblastsIKBKBARF6GTPIKBKGARF6GTPPMCYASAP3AcK311KAT2BASAP1Y782Adhesion, migrationand invasion of MCF-7 cellsMMP3CDH1SNAI2PTK2BY402KITLGCDH1CXCL8SNAI1CASP8VEGFATIMP1IL6CCR8 Receptor internalizationNRASLIN28Bhsa-miR-98-5phsa-miR-27b-3pIKBKBS181S177CDH1VIMPTK2VIMSNAI1SP1PSMAD2PSMAD3PCOL1A1Migrationand invasionof MDA-MB-231cellsHematopoiesisin myeloidlong-termbone marrowculturesIL15CCL2CCL3TIMP2TGFB1FGF2MAD1L1CREB1FOSMAPK8T183Y185MAPK9T183Y185ELMO1KIF5BMT-CO2CSF2MMP9CXCR4MTORS2481S2448ACTA2ACTA2hsa-miR-21-5pIntegrin clusteringAttenuation of PIP2 binding associated activation of Ezrin by acetylation PRKCAPPRKCAPProduction ofCollagen infibroblastsCOL1A2COL1A2CCR3CCR1CCR2CCR4CCR5 Antagonistic activityRAC1GTPInvasion andmigration ofA549 and H1299 cellsCDH1CDH2POU5F1BMI1Inducesstem cell-likecharacteristicsin HSC6, CAL33 andSCC15 cellsSNAI2SNAI1 Decreased expression of PTEN (inhibitor of AKT activity) regulated by hsa-miR-21-5p PRKCDCDH1MTDHTWIST1CDH1CDH2VIMKIF5BCDH1VIMALDH1CDH1VIMCDH1CD44LIN28ASNAI1SNAI2TWIST1ZEB1ZEB2LIMK1T508CFL1S3Cytoskeletonreorganizationin MDA-MB-231cellsPMCYPMCYEZRAcK253AcK263AcK258AcK60ARF6 richmembraneprotrusionsDissociationand increasedARF6 activityPMCYPMCYASAP1Y782 Activation of LFA-1 in polarised Th2-cellsITGALITGB2PMCYRelease of intracellular TGFB1IL10Secretion in memory CD4+ T cells CYNU Dissociation and activation of NF-kappaBCYNUPIK3R3Y199PIK3R1Y467PTENhsa-miR-92bhsa-miR-26bhsa-miR-877hsa-miR-27ahsa-miR-106ahsa-miR-17hsa-miR-20bhsa-let-7ehsa-miR-20ahsa-let-7bhsa-let-7dPost-transcriptional regulation of hsa-miR-98-5p TWIST1CDH1CDH2VIMReleasefromleukocytesF-actinpolymerizationin Th2 cellsVEGFCCDH1MMP2mRNAsLncRNAsFZD4PTENCCL18CCL18CCL18CCL18CCL18CCL18ReceptorProteinRNAMoleculeProtein-protein interactionsProtein-protein dissociationIncreased expressionDecreased expressionSmall molecule / metaboliteProtein 1Protein 2Protein complexProtein 1Protein 2Group of genes or proteinsfrom a study or gene familyAcetylationProteinRNAProteinRNAPost-Translational ModificationProteinPTMProteinPTMPhosphositesAcetylation sitesReported to be CCR8-mediatedReported to be PITPNM3-mediatedLeads to through knownunknown mechanisms(Multiple colored edges todisctinguish the crossing edges)CytoplasmPlasmamembraneNucleusProtein transport acrosscellular compartmentsPMCYNULeads to transcriptional ortranslational regulationFigure LegendInhibition of activityCDC25CSNAI2SNAI1CD44PROM1LDHALDHBLDHALDHBSLC2A1HIF1AMYCARNTHistamine


Description

A multi-cellular molecular signaling and functional network map of C-C Motif Chemokine Ligand 18 (CCL18): A chemokine with immunosuppressive and pro-tumor function

Comments

 
Manually Curated

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Bibliography

  1. Krohn SC, Bonvin P, Proudfoot AE; ''CCL18 exhibits a regulatory role through inhibition of receptor and glycosaminoglycan binding.''; PLoS One, 2013 PubMed Europe PMC Scholia
  2. Nibbs RJ, Salcedo TW, Campbell JD, Yao XT, Li Y, Nardelli B, Olsen HS, Morris TS, Proudfoot AE, Patel VP, Graham GJ; ''C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap.''; J Immunol, 2000 PubMed Europe PMC Scholia
  3. Lin X, Chen L, Yao Y, Zhao R, Cui X, Chen J, Hou K, Zhang M, Su F, Song E; ''CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis.''; Oncotarget, 2015 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
119075view21:19, 14 June 2021EweitzOntology Term : 'signaling pathway' added !
119074view21:18, 14 June 2021EweitzModified title
119015view18:48, 9 June 2021EgonwFixed the data source to NCBI Protein
116661view11:56, 9 May 2021KeshavNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTA2Rna59 (Entrez Gene)
ACTA2ProteinNP_001604.1 (RefSeq)
AKT1GeneProductNP_005154.2 (RefSeq)
ALDH1Rna102867337 (Entrez Gene)
ANXA2ProteinNP_004030.1 (RefSeq)
ARF6ProteinNP_001654.1 (RefSeq)
ARNTProtein205 (Entrez Gene)
ASAP1ProteinNP_060952.2 (RefSeq)
ASAP3ProteinNP_060177.2 (RefSeq)
ATE1-AS1Rna100130887 (Entrez Gene)
ATF3Rna467 (Entrez Gene)
ATP6VOE2-AS1Rna
BCYRN1Rna618 (Entrez Gene)
BMI1ProteinNP_005171.4 (RefSeq)
CASP8ProteinNP_001219.2 (RefSeq)
CCL18ProteinNP_002979.1 (RefSeq)
CCL2ProteinNP_002973.1 (RefSeq)
CCL3ProteinNP_002974.1 (RefSeq)
CCR1ProteinNP_001286.1 (RefSeq)
CCR2ProteinNP_001116868.1 (RefSeq)
CCR3ProteinNP_001828.1 (RefSeq)
CCR4ProteinNP_005499.1 (RefSeq)
CCR5ProteinNP_000570.1 (RefSeq)
CCR6ProteinNP_004358.2 (RefSeq)
CCR8Protein1237 (Entrez Gene)
CCR8ProteinNP_005192.1 (RefSeq)
CD44Rna960 (Entrez Gene)
CD44Rna960 (RefSeq)
CDC25CProteinNP_001781.2 (RefSeq)
CDH1Rna999 (Entrez Gene)
CDH1RnaNP_004351.1 (RefSeq)
CDH2Rna1000 (Entrez Gene)
CDH2ProteinNP_001783.2 (RefSeq)
CDH5ProteinNP_001786.2 (RefSeq)
CFL1 ProteinNP_005498.1 (RefSeq)
CHUKProteinNP_001269.3 (RefSeq)
COL1A1ProteinNP_000079.2 (RefSeq)
COL1A2Rna1278 (Entrez Gene)
COL1A2ProteinNP_000080.2 (RefSeq)
CREB1ProteinNP_004370.1 (RefSeq)
CSF2Rna1437 (Entrez Gene)
CXCL8ProteinNP_000575.1 (RefSeq)
CXCR4ProteinNP_003458.1 (RefSeq)
Ca++Metabolite271 (PubChem-substance)
ECI2-DTRna100507506 (Entrez Gene)
ELMO1 ProteinNP_055615.8 (RefSeq)
EP300Rna2033 (Entrez Gene)
EP300ProteinNP_001420.2 (RefSeq)
EZRProteinNP_003370.2 (RefSeq)
FAM74A4Rna7412 (Entrez Gene)
FGF2ProteinNP_001997.5 (RefSeq)
FN1Rna2335 (Entrez Gene)
FN1ProteinNP_002017.2 (RefSeq)
FOSProteinNP_005243.1 (RefSeq)
FZD4Rna8322 (Entrez Gene)
FZD4ProteinNP_036325.2 (RefSeq)
GOLGA6L17PRna642402 (Entrez Gene)
GPER1ProteinNP_001496.1 (RefSeq)
GSK3BProteinNP_002084.2 (RefSeq)
HIF1ARna3091 (Entrez Gene)
HIPK1-AS1Rna101928846 (Entrez Gene)