Overview of proinflammatory and profibrotic mediators (Homo sapiens)

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1TNFαCXC chemokine/receptor familyC chemokine/receptor familyColony stimulating factorsShared IL-2β chain (CD122)CC chemokine/receptor familyShared receptorsType II IFNCX3C chemokine/receptor familyIL-1Adaptive immunityIL-17Common β chain (CD131) receptor ligandsCommon γ chain receptor ligandsType III IFNCytokinesType I IFNIFNA7IL27IFNL2IL26IL5IL2CSF2IL36RNCTF1IL1RNIL9IL7IFNA13IL22IL19IL12BIFNA5IFNA17IL3IL23AIFNA16IL31SPP1CCL28IL11IL24IL12BTSLPIFNA8IL6IFNKIFNA14CCL1IL1F10TNFIFNA1IFNB1IL10IL13IL1BIL20IL33LIFIL1AIFNA6CSF1IL15IL12AIFNA2EPOEBI3IL4IFNL3IFNW1IL21IFNGIL24IFNA4IFNL1CNTFIL18CXCL1IL36AOSMIL25IFNL2IL37Cytokine stormIL2IL-8MMP3CSF3CCL2CSF2ROSCXCL10TNF alphaIL-12NF-kappa-B IL-1 BetaMMP1IL-6IL-6IL-1 BetaIL-8CCL2TNF alphaIL-12VEGFAMMP9TGFB1CXCL1CSF1AREGIL17FIL17AIL22CXCL9IFNGIFNA1Prostaglandin E2Prostaglandin I222Pro-inflammatory signallingAnti-inflammatory signallingIL15IL2IL36BIL36GLymphotoxin-alphaTNFSF13BTNFSF13IL17AIL17BIL17DIL17FIL17CIFNA10IFNA21IL12AIFNL3IFNL1CSF3CSF2IL-6ChemokinesCCL2CCL3CCL3L3CCL4CCL4L2CCL5CCL13CCL7CCL8CCL11CCL14CCL15CCL16CCL17CCL18CCL19CCL20CCL21CCL22CCL23CCL24CCL25CCL27CCL26XCL1XCL2CXCL2CXCL3CXCL5CXCL6PPBPCXCL10CXCL11CXCL12CXCL16CXCL17CX3CL1PF4PF4V1CXCL8CXCL9CXCL13CXCL14


Description

Inflammatory cytokines leading to cytokine storm after NF-kappa-B and prostaglandin activation. KEGG pathway 05171 and a paper by Robb et al. was referenced for the pathway development.

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Ontology Terms

 

Bibliography

  1. Turner MD, Nedjai B, Hurst T, Pennington DJ; ''Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.''; Biochim Biophys Acta, 2014 PubMed Europe PMC Scholia
  2. Robb CT, Goepp M, Rossi AG, Yao C; ''Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19.''; Br J Pharmacol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120801view12:31, 10 January 2022DuyguddOntology Term : 'pro-inflammatory cytokine mediated pathway' added !
116868view20:50, 14 May 2021Marvin M2Added chemokines
116764view09:58, 12 May 2021Marvin M2Added cytokines
116697view18:36, 9 May 2021AriajadhavModified description
116696view18:31, 9 May 2021AriajadhavAdded references to Prostaglandin pathways
116695view18:27, 9 May 2021AriajadhavAdded Prostaglandin mediated cytokine release to pathway
116384view11:18, 6 May 2021RaatsSModified description
116383view11:17, 6 May 2021RaatsSchanged title format. capitalized letters.
116382view11:16, 6 May 2021RaatsSAdded upstream genes and metabolites
116381view11:14, 6 May 2021RaatsSNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AREGGeneProductENSG00000109321 (Ensembl)
CCL11GeneProductENSG00000172156 (Ensembl)
CCL13GeneProductENSG00000181374 (Ensembl)
CCL14GeneProductENSG00000276409 (Ensembl)
CCL15GeneProductENSG00000275718 (Ensembl)
CCL16GeneProductENSG00000275152 (Ensembl)
CCL17GeneProductENSG00000102970 (Ensembl)
CCL18GeneProductENSG00000275385 (Ensembl)
CCL19GeneProductENSG00000172724 (Ensembl)
CCL1GeneProductENSG00000108702 (Ensembl)
CCL20GeneProductENSG00000115009 (Ensembl)
CCL21GeneProductENSG00000137077 (Ensembl)
CCL22GeneProductENSG00000102962 (Ensembl)
CCL23GeneProductENSG00000274736 (Ensembl)
CCL24GeneProductENSG00000106178 (Ensembl)
CCL25GeneProductENSG00000131142 (Ensembl)
CCL2GeneProduct6347 (Entrez Gene)
CCL26GeneProductENSG00000006606 (Ensembl)
CCL27GeneProductENSG00000213927 (Ensembl)
CCL28GeneProductENSG00000151882 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCL3GeneProductENSG00000277632 (Ensembl)
CCL3L3GeneProductENSG00000276085 (Ensembl)
CCL4GeneProductENSG00000275302 (Ensembl)
CCL4L2GeneProductENSG00000276070 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CCL7GeneProductENSG00000108688 (Ensembl)
CCL8GeneProductENSG00000108700 (Ensembl)
CNTFGeneProductENSG00000242689 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CTF1GeneProductENSG00000150281 (Ensembl)
CX3CL1GeneProductENSG00000006210 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL11GeneProductENSG00000169248 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCL13GeneProductENSG00000156234 (Ensembl)
CXCL14GeneProductENSG00000145824 (Ensembl)
CXCL16GeneProductENSG00000161921 (Ensembl)
CXCL17GeneProductENSG00000189377 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL2GeneProductENSG00000081041 (Ensembl)
CXCL3GeneProductENSG00000163734 (Ensembl)
CXCL5GeneProductENSG00000163735 (Ensembl)
CXCL6GeneProductENSG00000124875 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
CXCL9GeneProductENSG00000138755 (Ensembl)
EBI3GeneProductENSG00000105246 (Ensembl)
EPOGeneProductENSG00000130427 (Ensembl)
IFNA10GeneProductENSG00000186803 (Ensembl)
IFNA13GeneProductENSG00000233816 (Ensembl)
IFNA14GeneProductENSG00000228083 (Ensembl)
IFNA16GeneProductENSG00000147885 (Ensembl)
IFNA17GeneProductENSG00000234829 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNA21GeneProductENSG00000137080 (Ensembl)
IFNA2GeneProductENSG00000188379 (Ensembl)
IFNA4GeneProductENSG00000236637 (Ensembl)
IFNA5GeneProductENSG00000147873 (Ensembl)
IFNA6GeneProductENSG00000120235 (Ensembl)
IFNA7GeneProductENSG00000214042 (Ensembl)
IFNA8GeneProductENSG00000120242 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IFNKGeneProductENSG00000147896 (Ensembl)
IFNL1GeneProductENSG00000182393 (Ensembl)
IFNL2GeneProductENSG00000183709 (Ensembl)
IFNL3GeneProductENSG00000197110 (Ensembl)
IFNW1GeneProductENSG00000177047 (Ensembl)
IL-1 BetaGeneProductENSG00000125538 (Ensembl)
IL-12GeneProductIL12A (HGNC)
IL-6GeneProductENSG00000136244 (Ensembl)
IL-8GeneProductENSG00000169429 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL11GeneProductENSG00000095752 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL13GeneProductENSG00000169194 (Ensembl)
IL15GeneProductENSG00000164136 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL17BGeneProductENSG00000127743 (Ensembl)
IL17CGeneProductENSG00000124391 (Ensembl)
IL17DGeneProductENSG00000172458 (Ensembl)
IL17FGeneProductENSG00000112116 (Ensembl)
IL18GeneProductENSG00000150782 (Ensembl)
IL19GeneProductENSG00000142224 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1F10GeneProductENSG00000136697 (Ensembl)
IL1RNGeneProductENSG00000136689 (Ensembl)
IL20GeneProductENSG00000162891 (Ensembl)
IL21GeneProductENSG00000138684 (Ensembl)
IL22GeneProductENSG00000127318 (Ensembl)
IL22GeneProductIL22 (HGNC)
IL23AGeneProductENSG00000110944 (Ensembl)
IL24GeneProductENSG00000162892 (Ensembl)
IL25GeneProductENSG00000166090 (Ensembl)
IL26GeneProductENSG00000111536 (Ensembl)
IL27GeneProductENSG00000197272 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL31GeneProductENSG00000204671 (Ensembl)
IL33GeneProductENSG00000137033 (Ensembl)
IL36AGeneProductENSG00000136694 (Ensembl)
IL36BGeneProductENSG00000136696 (Ensembl)
IL36GGeneProductENSG00000136688 (Ensembl)
IL36RNGeneProductENSG00000136695 (Ensembl)
IL37GeneProductENSG00000125571 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL7GeneProductENSG00000104432 (Ensembl)
IL9GeneProductENSG00000145839 (Ensembl)
LIFGeneProductENSG00000128342 (Ensembl)
Lymphotoxin-alphaProteinP01374 (Uniprot-TrEMBL)
MMP1GeneProductENSG00000196611 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NF-kappa-B ProteinD6RC45 (Uniprot-TrEMBL)
OSMGeneProductENSG00000099985 (Ensembl)
PF4GeneProductENSG00000163737 (Ensembl)
PF4V1GeneProductENSG00000109272 (Ensembl)
PPBPGeneProductENSG00000163736 (Ensembl)
Prostaglandin E2Metabolite15551 (ChEBI)
Prostaglandin I2Metabolite35121-78-9 (CAS)
ROSMetaboliteCHEBI:26523 (ChEBI)
SPP1GeneProductENSG00000118785 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TNF alphaGeneProductENSG00000232810 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFSF13BGeneProductENSG00000102524 (Ensembl)
TNFSF13GeneProductENSG00000161955 (Ensembl)
TSLPGeneProductENSG00000145777 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
XCL1GeneProductENSG00000143184 (Ensembl)
XCL2GeneProductENSG00000143185 (Ensembl)

Annotated Interactions

No annotated interactions

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