Frustrated phagocytosis leading to malignant pleural mesothelioma (Homo sapiens)

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1, 2Increased secretion of proinflammatory mediatorsOxidative damage response DNA repair pathwaysNRF2 pathwayFrustrated phagocytosisIncreased reactive oxygen speciesCell cycle checkpoints DNA damage response Overview of proinflammatory and profibrotic mediatorsIncreased recruitment of inflammatory cells Genomic instabilityMesothelial cell proliferationMesotheliomaIncreased DNA damage and mutationCell CycleMalignant Pleural Mesothelioma


Adverse Outcome Pathway for malignant pleural mesothelioma, known to be initiated by asbestos and carbon nanotubes. This molecular AOP is based on

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Ontology Terms



  1. Akio Kuroda; ''Recent progress and perspectives on the mechanisms underlying Asbestos toxicity''; , 2021 PubMed Europe PMC Scholia
  2. Gupta SS, Singh KP, Gupta S, Dusinska M, Rahman Q; ''Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?''; Nanomaterials (Basel), 2022 PubMed Europe PMC Scholia


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124069view12:18, 15 September 2022Marvin M2Modified title
124068view12:18, 15 September 2022Marvin M2Modified description
124067view12:15, 15 September 2022Marvin M2Added references
123058view11:45, 22 June 2022Alexandraboschswitched Key Event
122802view12:21, 18 May 2022Alexandraboschfixed connection between Increased DNA damage and Genomic instability
122666view10:16, 28 April 2022Alexandraboschaddition of NRF2 pathway node
122653view10:14, 26 April 2022Alexandraboschadded KE IDs
122652view10:07, 26 April 2022Alexandraboschfixed layout
122651view10:04, 26 April 2022Alexandraboschaddition of pathway nodes
122650view09:32, 26 April 2022Alexandraboschadapted according to AOP-Wiki
122638view13:10, 24 April 2022Alexandraboschadded KE ID for oxidative stress, DNA double strand breaks, increased mutation, chromosome breaks and rearrangement & Mesothelioma
122637view12:57, 24 April 2022Alexandraboschadded KE ID for mesothelial cell proliferation
122589view15:04, 19 April 2022Marvin M2added KE ID for genomic instability
118961view10:48, 5 June 2021EweitzOntology Term : 'mesothelial cell' added !
116743view15:48, 11 May 2021Marvin M2Ontology Term : 'malignant pleural mesothelioma' added !
116742view15:48, 11 May 2021Marvin M2Modified description
116741view15:40, 11 May 2021Marvin M2Added KE pathway
116328view15:05, 30 April 2021Marvin M2New pathway

External references


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NameTypeDatabase referenceComment
Cell CyclePathwayWP179 (WikiPathways)
Cell cycle checkpoints PathwayWP1775 (WikiPathways)
DNA damage response PathwayWP707 (WikiPathways)
DNA repair pathwaysPathwayWP4946 (WikiPathways)
Frustrated phagocytosisKey Event1668 (AOP-Wiki KE)
Genomic instabilityKey Event1896 (AOP-Wiki KE)
Increased DNA damage and mutationKey Event1669 (AOP-Wiki KE)
Increased reactive oxygen speciesKey Event1115 (AOP-Wiki KE)
Increased recruitment of inflammatory cells Key Event1497 (AOP-Wiki KE)
Increased secretion of proinflammatory mediatorsKey Event1496 (AOP-Wiki KE)
Malignant Pleural MesotheliomaPathwayWP5087 (WikiPathways)
Mesothelial cell proliferationKey Event870 (AOP-Wiki KE)
MesotheliomaKey Event1090 (AOP-Wiki KE)
NRF2 pathwayPathwayWP2884 (WikiPathways)
Overview of proinflammatory and profibrotic mediatorsPathwayWP5095 (WikiPathways)
Oxidative damage response PathwayWP3941 (WikiPathways)

Annotated Interactions

No annotated interactions

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