Nuclear Receptors (Mus musculus)

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1Estrogen ReceptorOrphan ReceptorAndrogen ReceptorSteroidogenic ReceptorNR5 SUPERFAMILYOrphan ReceptorHepatocyte Nuclear FactorProgesterone ReceptorCoup Transcription FactorNuclear Receptor RORRetinoic Acid Receptor RXRNuclear receptor TLXNR0 SUPERFAMILYOrphan NuclearReceptorOxysterols ReceptorNR4 SUPERFAMILYSteroid Hormone ReceptorNR2 SUPERFAMILYGlucocorticoid ReceptorVitamin D3 ReceptorRetinoic Acid ReceptorNR3 SUPERFAMILYThyroid ReceptorNR1 SUPERFAMILYOrphan Nuclear ReceptorPeroxisome ProliferatorActivated ReceptorEsr2Ror1ThrbThrbRxraNr0b1Nr1h3Nr2f6Nr1h2RxrbNr2e1ArRorcEsrraRargNr3c1Nr4a2PgrRxrgPpardVdrNr2c2Nr1i2RaraNr5a2Nr1i3Hnf4aRarbNr4a1RargPpargEsrrbPparaPpargEsr1Nr2f2ThraRoraNr5a1Nr1d2Nr2f1


Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia (wikipedia:Nuclear_receptor)


This pathway was inferred from Homo sapiens pathway WP170(r21037) with a 100% conversion rate.

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Ontology Terms



  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC Scholia


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89865view12:35, 6 October 2016MkutmonModified description
69979view21:18, 11 July 2013MaintBot
69978view21:18, 11 July 2013MaintBotupdated to 2013 schema
67533view11:22, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
41291view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
35767view00:11, 13 February 2010AlexanderPico
34567view21:44, 21 December 2009KhanspersLayout
32128view13:54, 14 August 2009MaintBotFixed group labels
30899view00:24, 30 July 2009MaintBotConverted from Homo sapiens
21750view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Nuclear Receptors]] moved to [[Pathway:WP509]]: Moved to stable identifier
8286view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Nuclear Receptors]] moved to [[Pathway:Mus musculus:Nuclear Receptors]]: Renaming species
7763view16:16, 18 December 2007MaintBotfixed category names
7435view12:42, 4 November 2007MaintBotAdded categories to GPML
6479view22:19, 22 May 2007E.Tuninskygpml file for [[Mouse:Nuclear_Receptors]]

External references


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NameTypeDatabase referenceComment
ArGeneProduct11835 (Entrez Gene)
Esr1GeneProduct13982 (Entrez Gene)
Esr2GeneProduct13983 (Entrez Gene)
EsrraGeneProduct26379 (Entrez Gene)
EsrrbGeneProduct26380 (Entrez Gene)
Hnf4aGeneProduct15378 (Entrez Gene)
Nr0b1GeneProduct11614 (Entrez Gene)
Nr1d2GeneProduct353187 (Entrez Gene)
Nr1h2GeneProduct22260 (Entrez Gene)
Nr1h3GeneProduct22259 (Entrez Gene)
Nr1i2GeneProduct18171 (Entrez Gene)
Nr1i3GeneProduct12355 (Entrez Gene)
Nr2c2GeneProduct22026 (Entrez Gene)
Nr2e1GeneProduct21907 (Entrez Gene)
Nr2f1GeneProduct13865 (Entrez Gene)
Nr2f2GeneProduct11819 (Entrez Gene)
Nr2f6GeneProduct13864 (Entrez Gene)
Nr3c1GeneProduct14815 (Entrez Gene)
Nr4a1GeneProduct15370 (Entrez Gene)
Nr4a2GeneProduct18227 (Entrez Gene)
Nr5a1GeneProduct26423 (Entrez Gene)
Nr5a2GeneProduct26424 (Entrez Gene)
PgrGeneProduct18667 (Entrez Gene)
PparaGeneProduct19013 (Entrez Gene)
PpardGeneProduct19015 (Entrez Gene)
PpargGeneProduct19016 (Entrez Gene)
RaraGeneProduct19401 (Entrez Gene)
RarbGeneProduct218772 (Entrez Gene)
RargGeneProduct19411 (Entrez Gene)
Ror1GeneProduct26563 (Entrez Gene)
RoraGeneProduct19883 (Entrez Gene)
RorcGeneProduct19885 (Entrez Gene)
RxraGeneProduct20181 (Entrez Gene)
RxrbGeneProduct20182 (Entrez Gene)
RxrgGeneProduct20183 (Entrez Gene)
ThraGeneProduct21833 (Entrez Gene)
ThrbGeneProduct21834 (Entrez Gene)
VdrGeneProduct22337 (Entrez Gene)

Annotated Interactions

No annotated interactions
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