Kinin-Kallikrein pathway (Homo sapiens)

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1, 2Blood vesselKLKB1Coagulation factor XIISERPING1BradykininCPN1des-arg(9) bradykininBDKRB1BDKRB2Kininogen-1


Kinin Kallikrein Pathway that leads to Bradykinin receptor 1 (BDKRB1) and receptor 2 (BDKRB2) activation in homo sapiens starting from FXII

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Ontology Terms



  1. Bryant JW, Shariat-Madar Z; ''Human plasma kallikrein-kinin system: physiological and biochemical parameters.''; Cardiovasc Hematol Agents Med Chem, 2009 PubMed Europe PMC Scholia
  2. Garvin MR, Alvarez C, Miller JI, Prates ET, Walker AM, Amos BK, Mast AE, Justice A, Aronow B, Jacobson D; ''A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm.''; Elife, 2020 PubMed Europe PMC Scholia


118192view11:43, 25 May 2021AriajadhavUpdated pathway data nodes
117971view11:02, 23 May 2021EweitzModified title
116322view11:37, 30 April 2021Marvin M2Ontology Term : 'kallikrein-kinin cascade pathway' added !
116313view15:13, 29 April 2021AriajadhavNew pathway

External references


View all...
NameTypeDatabase referenceComment
BDKRB1ProteinG3V4Y2 (Uniprot-TrEMBL)
BDKRB2Protein624 (Entrez Gene)
BradykininProtein9606 (NCBI Protein)
CPN1GeneProductENSG00000120054 (Ensembl)
Coagulation factor XIIProteinP00748 (Uniprot-TrEMBL)
KLKB1GeneProductENSG00000164344 (Ensembl)
Kininogen-1ProteinP01042 (Uniprot-TrEMBL)
SERPING1GeneProductENSG00000149131 (Ensembl)
des-arg(9) bradykininMetabolite133068 (ChEBI)

Annotated Interactions

No annotated interactions

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