Malignant pleural mesothelioma (Homo sapiens)

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14-3-314-3-3456361312633344122341236661, 66616616664466214643164346412114Co-factorMMTAMsGFsChronic inflammation, proliferation, angiogenesis,resistance to apoptosisCell cycle progression &ProliferationHippoCell survivalMAPKWntInflammatory cytokines,cellular stressesMAPK, JAK-STATCell invasionChemokines, Cytokines,Pro-angiogenic factorsAutophagyTranscriptionNeoangiogenesisCell growth,differentiationUbiquination degradationOther chemokines/cytokinesApoptosisChemokines/Cytokines etc.Wnt signalmTORAsbestos fibersGrowth arrestDNA-repairIncreased protein synthesis+ Cell growthInflammationAsbestos fibersCadherinsAP-1 dependent genes/Repair genesDegradationMDM2Cell growthIntegrinsAutophagyDNA-damageRTKsKIBRARHEBP53ERK5PIP3RNSMSKMEKKAJUBAAPCRAFDR5P21MAPK14RSKFAKIL-1BMEK1/2FOXO1CASPASE-114-3-3MEK5PDK1EIF4CDK2TSC1PRAS40SFRPCyclin DTCFc-fosCTNNBL1BECLIN1JNK1-3PIGFGSK3BCL2P14ARFSRCAXINS6VEGFBAXCyclinEAKTCUL1PIP2MNKPUMAHMGB1E2FLEFDKK1PAK/RACPRBTEL2CyclinD1BAKBTRCMLKMST1/2CDK4HIF1AP16INK4AMKSTATTSC2TTI1NF-KBMEK4/7LRPJAKBCLXLFZDCDK7RICTORMCL1MMP9S6KRAPTORGRB2ASKGDPPDGFc-junRASGTPMTORNLRP3SHCMDM2MMP2SAV1FIP200ATMLATS1/2fra-1BAP1AMOT4E-BPATG13ERK1/2PI3KMEK3/6DVLNF2/merlinMLST8TEADERK2ROSRAGEPTENULK1SOSMSIN1DEPTORRASMSKMNKMKTEL2TTI1MLST8DEPTORMTORYAPTAZMDM2CTNNBL1P21BAXTAZCTNNBL1CTNNBL1Cell transformationTFCo-TFE2FPRBHMGB1HMGB1PRAS40RAPTORTEL2TTI1MLST8DEPTORMTORHMGB1IL-1BPro IL-1BP21YAPTAZChemokines, Cytokines,Pro-angiogenic factorsCell survival6


Description

Malignant Pleural Mesothelioma is a rare cancer affecting the mesothelial cells of the lungs. 80% of the patients have been exposed to asbestos before being diagnosed, but only 5% of the people exposed to asbestos develop mesothelioma. Therefore, genetics are thought to play an important role in combination with asbestos' toxicological effects. Several pathways have been identified to contribute to the development of the disease.

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Bibliography

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  1. Urso L, Calabrese F, Favaretto A, Conte P, Pasello G; ''Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment.''; Crit Rev Oncol Hematol, 2016 PubMed Europe PMC Scholia
  2. Cakiroglu E, Senturk S; ''Genomics and Functional Genomics of Malignant Pleural Mesothelioma.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
  3. Benedetti S, Nuvoli B, Catalani S, Galati R; ''Reactive oxygen species a double-edged sword for mesothelioma.''; Oncotarget, 2015 PubMed Europe PMC Scholia
  4. Mossman BT, Shukla A, Heintz NH, Verschraegen CF, Thomas A, Hassan R; ''New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas.''; Am J Pathol, 2013 PubMed Europe PMC Scholia
  5. Xue J, Patergnani S, Giorgi C, Suarez J, Goto K, Bononi A, Tanji M, Novelli F, Pastorino S, Xu R, Caroccia N, Dogan AU, Pass HI, Tognon M, Pinton P, Gaudino G, Mak TW, Carbone M, Yang H; ''Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy.''; Proc Natl Acad Sci U S A, 2020 PubMed Europe PMC Scholia
  6. Hylebos M, Van Camp G, van Meerbeeck JP, Op de Beeck K; ''The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing.''; J Thorac Oncol, 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
119094view08:20, 17 June 2021FinterlyRemoved PublicationXref and corresponding BiopaxRef with no information
118962view10:50, 5 June 2021EweitzOntology Term : 'altered autophagy pathway' added !
117773view13:57, 22 May 2021EweitzModified title
117638view14:48, 21 May 2021ZiskaChanged group identifiers
116765view10:02, 12 May 2021ZiskaAdded identifier for PIP3
116740view15:26, 11 May 2021Marvin M2Enlarged asbestos for clarity
116739view15:15, 11 May 2021Marvin M2Updated layout
116665view12:45, 9 May 2021ZiskaAdded headings, moved pathway
116388view14:42, 6 May 2021Marvin M2Modified description
116333view15:25, 30 April 2021Marvin M2Ontology Term : 'mesothelial cell of pleura' added !
116332view15:23, 30 April 2021Marvin M2Ontology Term : 'disease pathway' added !
116331view15:23, 30 April 2021Marvin M2Ontology Term : 'mesothelial cell' added !
116330view15:23, 30 April 2021Marvin M2Ontology Term : 'malignant pleural mesothelioma' added !
116329view15:22, 30 April 2021Marvin M2Corrected name errors and connected lines
116302view09:16, 29 April 2021ZiskaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
14-3-3ProteinA0A0J9YWE8 (Uniprot-TrEMBL)
4E-BPGeneProductENSG00000187840 (Ensembl)
AJUBAGeneProductENSG00000129474 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
AMOTGeneProductENSG00000126016 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
ASKGeneProductENSG00000115687 (Ensembl)
ATG13GeneProductENSG00000175224 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
AXINGeneProductENSG00000168646 (Ensembl)
BAKGeneProductENSG00000030110 (Ensembl)
BAP1GeneProductENSG00000163930 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCLXLGeneProductENSG00000171791 (Ensembl)
BECLIN1GeneProductENSG00000126581 (Ensembl)
BTRCGeneProductENSG00000166167 (Ensembl)
CASPASE-1GeneProductENSG00000137752 (Ensembl)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK7GeneProductENSG00000134058 (Ensembl)
CTNNBL1GeneProductENSG00000132792 (Ensembl)
CUL1GeneProductENSG00000055130 (Ensembl)
Cyclin DGeneProductENSG00000110092 (Ensembl)
CyclinD1GeneProductENSG00000110092 (Ensembl)
CyclinEGeneProductENSG00000105173 (Ensembl)
DEPTORGeneProductENSG00000155792 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DR5GeneProductENSG00000196363 (Ensembl)
DVLGeneProductENSG00000107404 (Ensembl)
E2FGeneProductENSG00000101412 (Ensembl)
EIF4GeneProductENSG00000114867 (Ensembl)
ERK1/2GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
ERK5GeneProductENSG00000166484 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FIP200GeneProductENSG00000023287 (Ensembl)
FOXO1GeneProductENSG00000150907 (Ensembl)
FZDGeneProductENSG00000157240 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3GeneProductENSG00000105723 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
HIF1AGeneProductENSG00000100644 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
IL-1BGeneProductENSG00000125538 (Ensembl)
JAKGeneProductENSG00000162434 (Ensembl)
JNK1-3GeneProductENSG00000107643 (Ensembl)
KIBRAGeneProductENSG00000113645 (Ensembl)
LATS1/2GeneProductENSG00000131023 (Ensembl)
LEFGeneProductENSG00000138795 (Ensembl)
LRPGeneProductENSG00000123384 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MCL1GeneProductENSG00000143384 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MEK1/2GeneProductENSG00000169032 (Ensembl)
MEK3/6GeneProductENSG00000034152 (Ensembl)
MEK4/7GeneProductENSG00000065559 (Ensembl)
MEK5GeneProductENSG00000137764 (Ensembl)
MEKKGeneProductENSG00000095015 (Ensembl)
MKGeneProductENSG00000110492 (Ensembl)
MLKGeneProductENSG00000168404 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MNKGeneProductENSG00000079277 (Ensembl)
MSIN1GeneProductENSG00000119487 (Ensembl)
MSKGeneProductENSG00000100784 (Ensembl)
MST1/2GeneProductENSG00000173531 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NF-KBGeneProductENSG00000109320 (Ensembl)
NF2/merlinGeneProductENSG00000186575 (Ensembl)
NLRP3GeneProductENSG00000162711 (Ensembl)
P14ARFGeneProductENSG00000147889 (Ensembl)
P16INK4AGeneProductENSG00000147889 (Ensembl)
P21GeneProductENSG00000124762 (Ensembl)
P53GeneProductENSG00000141510 (Ensembl)
PAK/RACGeneProductENSG00000149269 (Ensembl)
PDGFGeneProductENSG00000197461 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PIGFGeneProductENSG00000151665 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PRAS40GeneProductENSG00000204673 (Ensembl)
PRBGeneProductENSG00000251655 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
PUMAGeneProductENSG00000105327 (Ensembl)
Pro IL-1BGeneProductENSG00000125538 (Ensembl)
RAFGeneProductENSG00000132155 (Ensembl)
RAGEGeneProductENSG00000204305 (Ensembl)
RAPTORGeneProductENSG00000141564 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
RNSMetaboliteQ225595 (Wikidata)
ROSMetaboliteCHEBI:70982 (ChEBI)
RSKGeneProductENSG00000160469 (Ensembl)
S6GeneProductENSG00000137154 (Ensembl)
S6KGeneProductENSG00000071242 (Ensembl)
SAV1GeneProductENSG00000151748 (Ensembl)
SFRPGeneProductENSG00000104332 (Ensembl)
SHCGeneProductENSG00000160691 (Ensembl)
SOSGeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STATGeneProductENSG00000115415 (Ensembl)
TAZGeneProductENSG00000102125 (Ensembl)
TCFGeneProductENSG00000081059 (Ensembl)
TEADGeneProductENSG00000187079 (Ensembl)
TEL2GeneProductENSG00000100726 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
TTI1GeneProductENSG00000101407 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
VEGFGeneProductENSG00000112715 (Ensembl)
YAPGeneProductENSG00000137693 (Ensembl)
c-fosMetaboliteCHEBI:62519 (ChEBI)
c-junGeneProductENSG00000177606 (Ensembl)
fra-1 GeneProductENSG00000175592 (Ensembl)

Annotated Interactions

No annotated interactions

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