Malignant pleural mesothelioma (Homo sapiens)

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TCF7L1TCF714-3-315, 30537193728, 37323727372728413710403417402340294017, 30, 36, 382237402922403740236440374044028, 94024, 1729296402917, 341929240372175, 374104024, 26, 302937404272723025243920203939272639122112262012202620202624202627122624262426263820, 391224, 26112426202624122426261839262222017, 26242724122424182639262712TAMsMMChronic inflammation, proliferation, angiogenesis,resistance to apoptosisCollagenolysispolycomb repressive complex 2 (PRC2)VDACJNKsMEKKa-cateninTumorigenesis & ProliferationPI3KLegendAMPKCancer-associated fibroblastsGrowth arrestIntegrinsLAT1Prognostic markerscytochrome cGene or protein IntegrinsMesothelial cellWNT pathwayRTKsTranscriptionDegradationHippo-Merlin signalingStiff and fibronectin rich ECMOther chemokines/cytokinesMAPK pathwayInflammatory cytokines,cellular stressesCell survivalInflammationCell growth,differentiationChemokines, Cytokines,Pro-angiogenic factorsAutophagyChemokines/Cytokines etc.MetastasisAngiogenesisDNA methylationGenetic aberrationsCell survival & growthReplicative immortalityAP-1 dependent genes/Repair genesCadherinsCell growthIncreased protein synthesis+ Cell growthDNA-damageATF3EEDTGFAPORCNSPARCDDIT3RNF2MDM4TGFB1VEGFAMYCIL10CCND1DKK2ACTA1BAG2HBEGFCCL2KDM6ACCL2CSF2HGFYY1CER1ACTA2PD-L1IGF1EZH2RASSF7RAFBMI1DKK1DKK4ITGB1IL6CSF1FOXM1MAPK8RASSF2KITLGPLCB4CD44FGF1Unfolded protein responseCXCL12SLC2A1RASSF3ACTBTCA cycleKITPHC1AREGLAMC1IDO1RASSF5NOTUMVGLL4CTGFFGF2RBBP4let-7LIN28BHGFLIMD1RASSF4EGFRCTGFRASSF1SLC3A2PPARGC1AIGF1RMETITPR3LAMA1RASSF6CYCSCOL4A1WIF1RING1ITGA1PDGFRAMYCCTNNA1KMT2CBARD1FGF2SUZ12ASXL1SOSTBTCBRCA1HCFC1FGFR1MCUglucoseLGALS9Ca2+FN1SERPINF128, 3737714CDK4Histone modificationsTP53BCL2CDKN2A33BAXRAGECNNE114-3-3HIF1APIP3MCL1MMP9CDK7PDK1MAP3K5NF2RASNF-KBDNA repairMEK5GRB2TSC1CUL1ATMSTATSP1ROSMAPK14SHCSAV1ERK2LATS1ATG13JAKCDKN1ACDK2Cell cycleSETD2AngiogenesisULK238HMGB1c-fosMMP2MAP2K4E2F1LATS232, 38PDGFGDPBTRCMAXKIBRACyclin DGABPAIL-1BFOXO1PUMAMST1ERK1EIF4c-junNLRP3p16INK4AVEGFFAKRHEBMDM2AJUBASETD5RPS6KA1MAP2K1MAP3K9PIGFfra-1TEAD1TSC2PIP2CASPASE-1AMOTRNSDR54E-BPSRCBAP126, 38PTENERK5MAP2K6TERT1, 35BECLIN1GTPBAKApoptosisULK1SETDB1MAD1BCLXLPRB1p14ARFSOSSTATAP2CCND1FIP200RASMKNK1MAPKAPK2YAPWWTR1MDM2P21BAXE2F1PRB1HMGB1HMGB1PRAS40TEL2TTI1MLST8DEPTORMTORHMGB1IL-1BPro IL-1BP21YAPWWTR1Chemokines, Cytokines,Pro-angiogenic factorsCell survival26Wnt signalingAutophagyCell migrationNucleusNF-KBSRCNF232PAK1PAK2PAK3PAK4PAK5PAK627MAPK signaling pathwayMicroenvironment interactionsAngiogenesisVEGFBVEGFCVEGFD37TGFB1IL6PDGFAPDGFBPDGFCPDGFDMMP2MMP331MMP931MMP1413EGFFGFR2FGFR3FGFR44040IGF240METPDGFRBCOL4A237COL4A328, 37COL4A4COL4A5COL4A6LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3ITGA2ITGA3ITGA4ITGAVITGA6ITGB2ITGB3ITGB4LamininsFN137COL4A1COL4A2COL4A337COL4A4COL4A5COL4A6LAMA1LAMC1LAMA2LAMA3LAMA4LAMA5LAMB1LAMB2LAMB3LAMC2LAMC3CCL4CXCL10CXCL5CXCL12TGFB1VEGFAVEGFBVEGFCVEGFDglucoseSLC7A5ArginineArginineTryptophanTryptophanKynurenineTumor-associated macrophagesIL34PhagocytosisCXCL5CXCL12TGFB1T-LymphocytesCXCL5CXCL1IL6CXCL12CSF3PD-L1IL10Myeloid-Derived Suppressor Cellsprostaglandin E2CDH5CDH1CDH10CDH17CDH9CDH16CDH6CDH13CDH20CDH2CDH19CDH22CDH8CDH24CDH18CDH12CDH7CDH15CDH11CDH3CDH4PRKAB2PRKAB1PRKAA2PRKAG1PRKAA1PRKAG2PRKAG3FGFR2KDRINSRFGFR3IGF1RKITFGFR1EPHA2EGFRCSF1RFGFR4FLT1FLT4NGFRMETPDGFRAPDGFRBTEKFLT3NTRK1NTRK2RASMOB1AEFNA1FGF1FGF11FGF10EFNA2EGFFGF12CSF1ANGPT4ANGPT2ANGPT1VEGFAEFNA3EFNA4EFNA5FGF14FGF5FGF19FGF17FGF18FGF2FGF3FGF4FGF6FGF7FGF8FGF9VEGFDHGFIGF1IGF2INSKITLGFLT3LGVEGFCVEGFBPDGFBPGFPDGFANGFPDGFCFGF21FGF23FGF22PDGFDFGF20FGF13Growth FactorFGF19NTF3NTF4BDNFTGFAROSVEGFAVEGFBVEGFCVEGFDCCL55CD47ACTC1ACTG1ACTG2ITGB1ITGA1ITGA2ITGA3ITGA4ITGAVITGA6CTNNA2CTNNA3B1-integrinMOB1BWWTR1TEAD2TEAD3TEAD4STK327MAPK9MAPK10MAPK8MAPK9MAPK10JNKs27MINK1TNIKMAP4K1MAP4K2MAP4K4MAP4K3PSTK38LNDRG1FZD3FZD8FZD10FZD7FZD4FZD1FZD6FZD5FZD9FZD2SFRP1SFRP2SFRP4SFRP5Frizzled LigandsWNT3AWNT7AWNT11WNT1WNT5BWNT2WNT2BWNT6WNT5AWNT16WNT4WNT3WNT10BWNT7BWNT10AWNT16ROR1RYKROR2LRP5LRP6KREMEN12222FRAT1GSK3BCSNK2BAPCCSNK1ECTNNB1CSNK1A1CSNK2A1AXIN1CSNK1A1LCSNK2A3CSNK2A2CTNNB1PPFRAT2CXXC4SENP22DVL3DVL2DVL126S Proteasome DegradationCTNNB1UbPLEF1PPTCF7L2PPCTNNB1CHD82SOX172CTBP1CTBP22PLAUCCND1JUNCCND3FOSL1MYCCCND2PIK3CAPIK3CBPIK3CDRPS6KB1RPS6KB2EIF4BRPS6PIK3CGAKT1AKT3AKT2PI3K-Akt signaling pathwayERK2JAK/STAT pathwayMAP2K2MAP2K7MAP2K3222222MAP3K1MAP3K2MAP3K3MAP3K4MAP3K6ASKMAP3K10MAP3K11MLK22p38MEF2DATF2STAT1CREB1RPS6KA5ELK1MAXHMGN1DDIT3MKNK2MNKMAPKAPK2MKRPS6KA5MKNK1MKNK2MNKRPS6KA3RPS6KB1RPS6KB2RSKRPTOR7PRAS40TEL2TTI1MLST8DEPTORMTORRPTOR7MYC7Frequently mutated tumor suppressor geneFrequently mutated oncogeneMetabolitePathwayCITTNNT1ADAMTS1MAD2L1UHRF1PRSS23KIF23PODXLTRAF2MDKSELECTHRC1DSC3Ca2+Endoplasmic reticulumCa2+CYCSpolycomb repressive complex 1 (PRC1)BARD1BRCA114-3-3HCFC1OGTHCFC14, 17Gluconeogenesis17171717