Malignant pleural mesothelioma (Homo sapiens)
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TCF7L1
TCF7
14-3-3
15, 30
5
37
19
37
28, 37
32
37
27
37
27
28
41
37
10
40
34
17
40
23
40
29
40
17, 30, 36, 38
2
2
37
40
29
2
2
40
37
40
2
36
4
40
37
40
4
40
2
8, 9
40
2
4, 17
29
29
6
40
29
17, 34
19
29
2
40
37
2
17
5, 37
4
10
40
2
4, 26, 30
29
37
40
4
27
27
2
30
25
24
39
20
20
39
39
27
26
39
12
21
12
26
20
12
20
26
20
20
26
24
20
26
27
12
26
24
26
24
26
26
38
20, 39
12
24, 26
11
24
26
20
26
24
12
24
26
26
18
39
26
22
2
20
17, 26
24
27
24
12
24
24
18
26
39
26
27
12
TAMs
MM
Chronic inflammation,
proliferation, angiogenesis,
resistance to apoptosis
Collagenolysis
polycomb repressive
complex 2 (PRC2)
VDAC
JNKs
MEKK
a-catenin
Tumorigenesis & Proliferation
PI3K
Legend
AMPK
Cancer-associated fibroblasts
Growth arrest
Integrins
LAT1
Prognostic markers
cytochrome c
Gene or protein
Integrins
Mesothelial cell
WNT pathway
RTKs
Transcription
Degradation
Hippo-Merlin signaling
Stiff and
fibronectin rich ECM
Other chemokines/
cytokines
MAPK pathway
Inflammatory cytokines,
cellular stresses
Cell survival
Inflammation
Cell growth,
differentiation
Chemokines, Cytokines,
Pro-angiogenic factors
Autophagy
Chemokines/
Cytokines etc.
Metastasis
Angiogenesis
DNA methylation
Genetic aberrations
Cell survival & growth
Replicative immortality
AP-1 dependent
genes/Repair genes
Cadherins
Cell growth
Increased protein synthesis
+ Cell growth
DNA-damage
ATF3
EED
TGFA
PORCN
SPARC
DDIT3
RNF2
MDM4
TGFB1
VEGFA
MYC
IL10
CCND1
DKK2
ACTA1
BAG2
HBEGF
CCL2
KDM6A
CCL2
CSF2
HGF
YY1
CER1
ACTA2
PD-L1
IGF1
EZH2
RASSF7
RAF
BMI1
DKK1
DKK4
ITGB1
IL6
CSF1
FOXM1
MAPK8
RASSF2
KITLG
PLCB4
CD44
FGF1
Unfolded
protein
response
CXCL12
SLC2A1
RASSF3
ACTB
TCA cycle
KIT
PHC1
AREG
LAMC1
IDO1
RASSF5
NOTUM
VGLL4
CTGF
FGF2
RBBP4
let-7
LIN28B
HGF
LIMD1
RASSF4
EGFR
CTGF
RASSF1
SLC3A2
PPARGC1A
IGF1R
MET
ITPR3
LAMA1
RASSF6
CYCS
COL4A1
WIF1
RING1
ITGA1
PDGFRA
MYC
CTNNA1
KMT2C
BARD1
FGF2
SUZ12
ASXL1
SOST
BTC
BRCA1
HCFC1
FGFR1
MCU
glucose
LGALS9
Ca2+
FN1
SERPINF1
28, 37
37
7
14
CDK4
Histone modifications
TP53
BCL2
CDKN2A
33
BAX
RAGE
CNNE1
14-3-3
HIF1A
PIP3
MCL1
MMP9
CDK7
PDK1
MAP3K5
NF2
RAS
NF-KB
DNA repair
MEK5
GRB2
TSC1
CUL1
ATM
STAT
SP1
ROS
MAPK14
SHC
SAV1
ERK2
LATS1
ATG13
JAK
CDKN1A
CDK2
Cell cycle
SETD2
Angiogenesis
ULK2
38
HMGB1
c-fos
MMP2
MAP2K4
E2F1
LATS2
32, 38
PDGF
GDP
BTRC
MAX
KIBRA
Cyclin D
GABPA
IL-1B
FOXO1
PUMA
MST1
ERK1
EIF4
c-jun
NLRP3
p16INK4A
VEGF
FAK
RHEB
MDM2
AJUBA
SETD5
RPS6KA1
MAP2K1
MAP3K9
PIGF
fra-1
TEAD1
TSC2
PIP2
CASPASE-1
AMOT
RNS
DR5
4E-BP
SRC
BAP1
26, 38
PTEN
ERK5
MAP2K6
TERT
1, 35
BECLIN1
GTP
BAK
Apoptosis
ULK1
SETDB1
MAD1
BCLXL
PRB1
p14ARF
SOS
STAT
AP2
CCND1
FIP200
RAS
MKNK1
MAPKAPK2
YAP
WWTR1
MDM2
P21
BAX
E2F1
PRB1
HMGB1
HMGB1
PRAS40
TEL2
TTI1
MLST8
DEPTOR
MTOR
HMGB1
IL-1B
Pro IL-1B
P21
YAP
WWTR1
Chemokines, Cytokines,
Pro-angiogenic factors
Cell survival
26
Wnt signaling
Autophagy
Cell migration
Nucleus
NF-KB
SRC
NF2
32
PAK1
PAK2
PAK3
PAK4
PAK5
PAK6
27
MAPK signaling pathway
Microenvironment
interactions
Angiogenesis
VEGFB
VEGFC
VEGFD
37
TGFB1
IL6
PDGFA
PDGFB
PDGFC
PDGFD
MMP2
MMP3
31
MMP9
31
MMP14
13
EGF
FGFR2
FGFR3
FGFR4
40
40
IGF2
40
MET
PDGFRB
COL4A2
37
COL4A3
28, 37
COL4A4
COL4A5
COL4A6
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC2
LAMC3
ITGA2
ITGA3
ITGA4
ITGAV
ITGA6
ITGB2
ITGB3
ITGB4
Laminins
FN1
37
COL4A1
COL4A2
COL4A3
37
COL4A4
COL4A5
COL4A6
LAMA1
LAMC1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC2
LAMC3
CCL4
CXCL10
CXCL5
CXCL12
TGFB1
VEGFA
VEGFB
VEGFC
VEGFD
glucose
SLC7A5
Arginine
Arginine
Tryptophan
Tryptophan
Kynurenine
Tumor-associated macrophages
IL34
Phagocytosis
CXCL5
CXCL12
TGFB1
T-Lymphocytes
CXCL5
CXCL1
IL6
CXCL12
CSF3
PD-L1
IL10
Myeloid-Derived Suppressor Cells
prostaglandin E2
CDH5
CDH1
CDH10
CDH17
CDH9
CDH16
CDH6
CDH13
CDH20
CDH2
CDH19
CDH22
CDH8
CDH24
CDH18
CDH12
CDH7
CDH15
CDH11
CDH3
CDH4
PRKAB2
PRKAB1
PRKAA2
PRKAG1
PRKAA1
PRKAG2
PRKAG3
FGFR2
KDR
INSR
FGFR3
IGF1R
KIT
FGFR1
EPHA2
EGFR
CSF1R
FGFR4
FLT1
FLT4
NGFR
MET
PDGFRA
PDGFRB
TEK
FLT3
NTRK1
NTRK2
RAS
MOB1A
EFNA1
FGF1
FGF11
FGF10
EFNA2
EGF
FGF12
CSF1
ANGPT4
ANGPT2
ANGPT1
VEGFA
EFNA3
EFNA4
EFNA5
FGF14
FGF5
FGF19
FGF17
FGF18
FGF2
FGF3
FGF4
FGF6
FGF7
FGF8
FGF9
VEGFD
HGF
IGF1
IGF2
INS
KITLG
FLT3LG
VEGFC
VEGFB
PDGFB
PGF
PDGFA
NGF
PDGFC
FGF21
FGF23
FGF22
PDGFD
FGF20
FGF13
Growth Factor
FGF19
NTF3
NTF4
BDNF
TGFA
ROS
VEGFA
VEGFB
VEGFC
VEGFD
CCL5
5
CD47
ACTC1
ACTG1
ACTG2
ITGB1
ITGA1
ITGA2
ITGA3
ITGA4
ITGAV
ITGA6
CTNNA2
CTNNA3
B1-integrin
MOB1B
WWTR1
TEAD2
TEAD3
TEAD4
STK3
27
MAPK9
MAPK10
MAPK8
MAPK9
MAPK10
JNKs
27
MINK1
TNIK
MAP4K1
MAP4K2
MAP4K4
MAP4K3
P
STK38L
NDRG1
FZD3
FZD8
FZD10
FZD7
FZD4
FZD1
FZD6
FZD5
FZD9
FZD2
SFRP1
SFRP2
SFRP4
SFRP5
Frizzled Ligands
WNT3A
WNT7A
WNT11
WNT1
WNT5B
WNT2
WNT2B
WNT6
WNT5A
WNT16
WNT4
WNT3
WNT10B
WNT7B
WNT10A
WNT16
ROR1
RYK
ROR2
LRP5
LRP6
KREMEN1
2
2
2
2
FRAT1
GSK3B
CSNK2B
APC
CSNK1E
CTNNB1
CSNK1A1
CSNK2A1
AXIN1
CSNK1A1L
CSNK2A3
CSNK2A2
CTNNB1
P
P
FRAT2
CXXC4
SENP2
2
DVL3
DVL2
DVL1
26S Proteasome
Degradation
CTNNB1
Ub
P
LEF1
P
P
TCF7L2
P
P
CTNNB1
CHD8
2
SOX17
2
CTBP1
CTBP2
2
PLAU
CCND1
JUN
CCND3
FOSL1
MYC
CCND2
PIK3CA
PIK3CB
PIK3CD
RPS6KB1
RPS6KB2
EIF4B
RPS6
PIK3CG
AKT1
AKT3
AKT2
PI3K-Akt signaling pathway
ERK2
JAK/STAT pathway
MAP2K2
MAP2K7
MAP2K3
22
22
22
MAP3K1
MAP3K2
MAP3K3
MAP3K4
MAP3K6
ASK
MAP3K10
MAP3K11
MLK
22
p38
MEF2D
ATF2
STAT1
CREB1
RPS6KA5
ELK1
MAX
HMGN1
DDIT3
MKNK2
MNK
MAPKAPK2
MK
RPS6KA5
MKNK1
MKNK2
MNK
RPS6KA3
RPS6KB1
RPS6KB2
RSK
RPTOR
7
PRAS40
TEL2
TTI1
MLST8
DEPTOR
MTOR
RPTOR
7
MYC
7
Frequently mutated
tumor suppressor gene
Frequently mutated
oncogene
Metabolite
Pathway
CIT
TNNT1
ADAMTS1
MAD2L1
UHRF1
PRSS23
KIF23
PODXL
TRAF2
MDK
SELE
CTHRC1
DSC3
Ca2+
Endoplasmic reticulum
Ca2+
CYCS
polycomb repressive
complex 1 (PRC1)
BARD1
BRCA1
14-3-3
HCFC1
OGT
HCFC1
4, 17
Gluconeogenesis
17
17
17
17