Vasopressin-regulated water reabsorption (Homo sapiens)

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Collecting duct principal cell1-11NucleusTight junctionMicrotubuleDyneinF-actin depolymerizationWater homeostasisDNABasolateral membraneDynactinUrinary lumenRenal interstitiumfluid (blood)Urinary excretionARHGDIAAQP2WaterPRKACARAB5AADCY3AVPRAB11ADCTN2STX4GNASAQP3cAMPPRAB11BPRKACBPRKACGCREB3CREB1CREB3L2CREB3L3CREB3L1CREB3L4CREB5DYNC2H1DYNC2LI1DYNLL2DYNLL1DYNC1LI1DYNC1I2DYNC1I1DYNC1LI2DYNC1H1DCTN4DCTN1DCTN5DCTN6VAMP2NSFAQP2PAQP2PAQP2PWaterADCY6ADCY9ARHGDIBARHGDIGAVPR2AQP4AQP3AQP2RAB5BRAB5CWaterAQP2PTight junctionWaterApicalmembraneRecyclingExocytosisEarly endosomeDegradation


This pathway describes Vasopressin-regulated water reabsorption from the kidney tubules of the nephrons back into the circulation. Vasopressin, antidiuretic hormone (ADH), is a peptide hormone produced in neurons of the hypothalamus in response to changes in response to extracellular fluid hypertonicity (hyperosmolality), and is secreted into the circulation. When it reaches the kidney, it binds to Vasopressin 2 receptors, triggering an intracellular signaling cascade that ultimately leads to aquaporin 2 (AQP2) vesicles inserted in the apical membrane. This increases the water permeability of the membrane. An osmotic gradient then drives water transport from the collecting duct through AQP2, and water exits the cell on the basolateral side, and back into the circulation.

This description was adapted from Wikipedia and KEGG.

This pathway was modeled from KEGG.

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  1. Boone M, Deen PM; ''Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.''; Pflugers Arch, 2008 PubMed Europe PMC Scholia
  2. Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T; ''Localization and trafficking of aquaporin 2 in the kidney.''; Histochem Cell Biol, 2008 PubMed Europe PMC Scholia
  3. Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frøkiaer J, Marples D; ''Physiology and pathophysiology of renal aquaporins.''; J Am Soc Nephrol, 1999 PubMed Europe PMC Scholia
  4. Marples D, Frøkiaer J, Nielsen S; ''Long-term regulation of aquaporins in the kidney.''; Am J Physiol, 1999 PubMed Europe PMC Scholia
  5. Ward DT, Hammond TG, Harris HW; ''Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.''; Annu Rev Physiol, 1999 PubMed Europe PMC Scholia
  6. Fenton RA, Moeller HB; ''Recent discoveries in vasopressin-regulated aquaporin-2 trafficking.''; Prog Brain Res, 2008 PubMed Europe PMC Scholia
  7. Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA; ''Aquaporins in the kidney: from molecules to medicine.''; Physiol Rev, 2002 PubMed Europe PMC Scholia
  8. Deen PM, van Balkom BW, Kamsteeg EJ; ''Routing of the aquaporin-2 water channel in health and disease.''; Eur J Cell Biol, 2000 PubMed Europe PMC Scholia
  9. Bonilla-Felix M; ''Development of water transport in the collecting duct.''; Am J Physiol Renal Physiol, 2004 PubMed Europe PMC Scholia
  10. Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA; ''Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.''; Physiol Genomics, 2008 PubMed Europe PMC Scholia
  11. Nguyen MK, Nielsen S, Kurtz I; ''Molecular pathogenesis of nephrogenic diabetes insipidus.''; Clin Exp Nephrol, 2003 PubMed Europe PMC Scholia


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119785view22:36, 23 August 2021KhanspersModified description
119784view20:49, 23 August 2021Khanspersadded literature references
119783view20:37, 23 August 2021KhanspersOntology Term : 'kidney cell' added !
119782view20:32, 23 August 2021KhanspersOntology Term : 'water transport pathway' added !
119781view20:16, 23 August 2021KhanspersOntology Term : 'vasopressin signaling pathway' added !
119727view15:25, 8 August 2021Khanspersfixed unconnected
119726view15:24, 8 August 2021KhanspersModified description
119725view15:24, 8 August 2021KhanspersModified description
116565view21:56, 7 May 2021Khansperswork in progress
116564view21:40, 7 May 2021Khansperswork in progress
116287view23:16, 27 April 2021KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
ADCY3GeneProductENSG00000138031 (Ensembl)
ADCY6GeneProductENSG00000174233 (Ensembl)
ADCY9GeneProductENSG00000162104 (Ensembl)
AQP2GeneProductENSG00000167580 (Ensembl)
AQP3GeneProductENSG00000165272 (Ensembl)
AQP4GeneProductENSG00000171885 (Ensembl)
ARHGDIAGeneProductENSG00000141522 (Ensembl)
ARHGDIBGeneProductENSG00000111348 (Ensembl)
ARHGDIGGeneProductENSG00000242173 (Ensembl)
AVPGeneProductENSG00000101200 (Ensembl)
AVPR2GeneProductENSG00000126895 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12912
CREB3GeneProductENSG00000107175 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12913
CREB3L1GeneProductENSG00000157613 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26427
CREB3L2GeneProductENSG00000182158 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208647
CREB3L3GeneProductENSG00000060566 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208677
CREB3L4GeneProductENSG00000143578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78284
CREB5GeneProductENSG00000146592 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:231991
DCTN1GeneProductENSG00000204843 (Ensembl)
DCTN2GeneProductENSG00000175203 (Ensembl)
DCTN4GeneProductENSG00000132912 (Ensembl)
DCTN5GeneProductENSG00000166847 (Ensembl)
DCTN6GeneProductENSG00000104671 (Ensembl)
DYNC1H1GeneProductENSG00000197102 (Ensembl)
DYNC1I1GeneProductENSG00000158560 (Ensembl)
DYNC1I2GeneProductENSG00000077380 (Ensembl)
DYNC1LI1GeneProductENSG00000144635 (Ensembl)
DYNC1LI2GeneProductENSG00000135720 (Ensembl)
DYNC2H1GeneProductENSG00000187240 (Ensembl)
DYNC2LI1GeneProductENSG00000138036 (Ensembl)
DYNLL1GeneProductENSG00000088986 (Ensembl)
DYNLL2GeneProductENSG00000264364 (Ensembl)
GNASGeneProductENSG00000087460 (Ensembl)
NSFGeneProductENSG00000073969 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
RAB11AGeneProductENSG00000103769 (Ensembl)
RAB11BGeneProductENSG00000185236 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB5BGeneProductENSG00000111540 (Ensembl)
RAB5CGeneProductENSG00000108774 (Ensembl)
STX4GeneProductENSG00000103496 (Ensembl)
VAMP2GeneProductENSG00000220205 (Ensembl)
WaterMetaboliteHMDB02111 (HMDB)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions

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